Positive inotropic effect of purified green tea catechin derivative in guinea pig hearts: The measurements of cellular Ca2+ and nitric oxide release

2006 ◽  
Vol 552 (1-3) ◽  
pp. 123-130 ◽  
Author(s):  
Yoshihiro Hotta ◽  
Lei Huang ◽  
Tatsuya Muto ◽  
Michio Yajima ◽  
Kunihiro Miyazeki ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Guinea Pig ◽  
Green Tea ◽  
Positive Inotropic Effect ◽  
Inotropic Effect ◽  
Nitric Oxide Release ◽  
Green Tea Catechin

Calcium channels and excitation–contraction coupling in cardiac cells. II. A pharmacological study of the biphasic contraction in guinea-pig papillary muscle

1987 ◽  
Vol 65 (9) ◽  
pp. 1832-1839 ◽  
Author(s):  
E. Honoré ◽  
M. M. Adamantidis ◽  
B. A. Dupuis ◽  
C. E. Challice ◽  
P. Guilbault
Keyword(s):  
Guinea Pig ◽  
Papillary Muscle ◽  
Positive Inotropic Effect ◽  
Pharmacological Study ◽  
Negative Inotropic Effect ◽  
Cardiac Cells ◽  
Inotropic Effect ◽  
Free Solution ◽  
Contraction Coupling ◽  
Rich Solution

Biphasic contractions were obtained in guinea-pig papillary muscle by inducing partial depolarization in K+-rich solution (17 mM) in the presence of 0.3 μM isoproterenol. Mn2+ ions inhibited the two components of contraction in a similar way. Nifedipine and particularly Cd2+ ions specifically inhibited the second component of contraction. Isoproterenol and BAY K 8644 markedly increased the amplitude of the second component (P2) of contraction. Nevertheless, a moderate positive inotropic effect of isoproterenol was found on the first component (P1) of contraction when excitability was restored by 0.2 mM Ba instead of isoproterenol. Acetylcholine and hypoxia decreased the amplitude of the second component of contraction to a greater extent. In the presence of digoxin or Na+-free solution, P1was strongly increased. When sarcoplasmic reticular function was hindered by 1 mM caffeine or in the presence of Ca2+-free Sr2+ solution, digoxin always induced a negative inotropic effect on P2. Inversely in these conditions the transient positive inotropic effect of Na+-free solution was strongly reduced. These results are consistent with the hypothesis that the late component of contraction is triggered by the slow inward Ca2+ current and that the early component is due to Ca2+ release from the sarcoplasmic reticulum.

Studies on taurine positive inotropic effect in guinea pig ventricular strips

1988 ◽  
Vol 20 ◽  
pp. 93-94
Author(s):  
Flavia Franconi ◽  
Isabella Stendardi ◽  
Alberto Giotti
Keyword(s):  
Guinea Pig ◽  
Positive Inotropic Effect ◽  
Inotropic Effect

scholarly journals Inhibition of nitric oxide synthase augments the positive inotropic effect of nitric oxide donors in the rat heart

2000 ◽  
Vol 522 (2) ◽  
pp. 311-320 ◽  
Author(s):  
Gerhard Müller‐Strahl ◽  
Karin Kottenberg ◽  
Heinz‐Gerd Zimmer ◽  
Eike Noack ◽  
Georg Kojda
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Rat Heart ◽  
Positive Inotropic Effect ◽  
Inotropic Effect ◽  
Nitric Oxide Donors ◽  
Oxide Synthase

scholarly journals ATP is involved in myocardial and vascular effects of exogenous bradykinin in ejecting guinea pig heart

1999 ◽  
Vol 277 (2) ◽  
pp. H818-H825 ◽  
Author(s):  
Peter B. Anning ◽  
Bernard D. Prendergast ◽  
Philip A. MacCarthy ◽  
Ajay M. Shah ◽  
Derek C. Buss ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Guinea Pig ◽  
Coronary Flow ◽  
Pyridoxal Phosphate ◽  
Left Ventricular ◽  
Luciferase Assay ◽  
Disulfonic Acid ◽  
Vascular Effects ◽  
Guinea Pig Heart ◽  
Nitric Oxide Release

It has recently been reported that bradykinin induces selective left ventricular (LV) relaxation in isolated guinea pig hearts via the release of nitric oxide. Exogenous bradykinin also induces vasodilation, which is only partly due to nitric oxide release. In the present study we investigated the role of adenyl purines on these bradykinin-induced effects. Isolated ejecting guinea pig hearts were studied. LV pressure was monitored by a 2-Fr micromanometer-tipped catheter. ATP concentrations were measured using a luciferin-luciferase assay. Bradykinin (1 and 100 nM) caused a progressive acceleration of LV relaxation together with a transient increase in coronary flow. These effects were inhibited by the nonselective P2 purinoceptor antagonist suramin (1 μM, n = 6) but were unaffected by the selective P2x purinoceptor antagonist pyridoxal phosphate 6-azophenyl-2′,4′-disulfonic acid (1 μM, n = 6). These myocardial and vascular effects of bradykinin were associated with increased ATP levels in coronary effluent. These data suggest that the selective enhancement of LV relaxation and rise in coronary flow induced by exogenous bradykinin involve endogenous ATP and the subsequent stimulation of P2 purinoceptors.

Positive inotropic effect of nitric oxide in myocardium

1995 ◽  
Vol 50 (3) ◽  
pp. 233-237 ◽  
Author(s):  
Puneet Mohan ◽  
Stanislas U. Sys ◽  
Dirk L. Brutsaert
Keyword(s):  
Nitric Oxide ◽  
Positive Inotropic Effect ◽  
Inotropic Effect
Sign in / Sign up

Export Citation Format

Share Document