GMP production and characterization of leucine zipper-tagged tumor necrosis factor-related apoptosis-inducing ligand (LZ-TRAIL) for phase I clinical trial

2014 ◽  
Vol 740 ◽  
pp. 722-732 ◽  
Author(s):  
Jing Jiang ◽  
Xiaobin Liu ◽  
Leixiu Deng ◽  
Peipei Zhang ◽  
Guangjun Wang ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Tumor Necrosis Factor ◽  
Phase I ◽  
Tumor Necrosis ◽  
Leucine Zipper ◽  
Phase I Clinical Trial ◽  
Necrosis Factor ◽  
Gmp Production

A phase I clinical trial of recombinant human tumor necrosis factor given daily for five days

1989 ◽  
Vol 23 (3) ◽  
Author(s):  
PatrickJ. Creaven ◽  
DeanE. Brenner ◽  
J.Wayne Cowens ◽  
RobertP. Huben ◽  
RichardM. Wolf ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Tumor Necrosis Factor ◽  
Phase I ◽  
Tumor Necrosis ◽  
Human Tumor ◽  
Phase I Clinical Trial ◽  
Human Tumor Necrosis Factor ◽  
Necrosis Factor

Phase I clinical trial of recombinant human tumor necrosis factor

1987 ◽  
Vol 20 (2) ◽  
Author(s):  
PatrickJ. Creaven ◽  
JohnE. Plager ◽  
Sherry Dupere ◽  
RobertP. Huben ◽  
Hiroshi Takita ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Tumor Necrosis Factor ◽  
Phase I ◽  
Tumor Necrosis ◽  
Human Tumor ◽  
Phase I Clinical Trial ◽  
Human Tumor Necrosis Factor ◽  
Necrosis Factor

scholarly journals A phase I clinical trial of recombinant human tumor necrosis factor

Cancer ◽  
1988 ◽  
Vol 62 (12) ◽  
pp. 2467-2471 ◽  
Author(s):  
Edward T. Creagan ◽  
John S. Kovach ◽  
Charles G. Moertel ◽  
Stephen Frytak ◽  
Larry K. Kvols
Keyword(s):  
Clinical Trial ◽  
Tumor Necrosis Factor ◽  
Phase I ◽  
Tumor Necrosis ◽  
Human Tumor ◽  
Phase I Clinical Trial ◽  
Human Tumor Necrosis Factor ◽  
Necrosis Factor

scholarly journals The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF

2001 ◽  
Vol 21 (12) ◽  
pp. 3986-3994 ◽  
Author(s):  
Anne Devin ◽  
Yong Lin ◽  
Shoji Yamaoka ◽  
Zhiwei Li ◽  
Michael Karin ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Leucine Zipper ◽  
Nuclear Translocation ◽  
Ring Finger ◽  
Tnf Receptor ◽  
Death Domain ◽  
Iκb Kinase ◽  
Cytokine Tumor Necrosis Factor ◽  
Necrosis Factor

ABSTRACT The activation of IκB kinase (IKK) is a key step in the nuclear translocation of the transcription factor NF-κB. IKK is a complex composed of three subunits: IKKα, IKKβ, and IKKγ (also called NEMO). In response to the proinflammatory cytokine tumor necrosis factor (TNF), IKK is activated after being recruited to the TNF receptor 1 (TNF-R1) complex via TNF receptor-associated factor 2 (TRAF2). We found that the IKKα and IKKβ catalytic subunits are required for IKK-TRAF2 interaction. This interaction occurs through the leucine zipper motif common to IKKα, IKKβ, and the RING finger domain of TRAF2, and either IKKα or IKKβ alone is sufficient for the recruitment of IKK to TNF-R1. Importantly, IKKγ is not essential for TNF-induced IKK recruitment to TNF-R1, as this occurs efficiently in IKKγ-deficient cells. Using TRAF2−/− cells, we demonstrated that the TNF-induced interaction between IKKγ and the death domain kinase RIP is TRAF2 dependent and that one possible function of this interaction is to stabilize the IKK complex when it interacts with TRAF2.

Identification and characterization of a tumor necrosis factor receptor like protein encoded by Cyprinid Herpesvirus 2

2021 ◽  
Vol 116 ◽  
pp. 103930
Author(s):  
Jian-Fei Lu ◽  
Tian-Cheng Jin ◽  
Ting Zhou ◽  
Xin-Jiang Lu ◽  
Jian-Ping Chen ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Identification And Characterization ◽  
Necrosis Factor

scholarly journals Purification and biologic characterization of a specific tumor necrosis factor α inhibitor

1989 ◽  
Vol 264 (20) ◽  
pp. 11966-11973
Author(s):  
P Seckinger ◽  
S Isaaz ◽  
J M Dayer
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Specific Tumor ◽  
Factor Α ◽  
Biologic Characterization ◽  
Necrosis Factor

scholarly journals Characterization of golimumab, a human monoclonal antibody specific for human tumor necrosis factor α

mAbs ◽  
2010 ◽  
Vol 2 (4) ◽  
pp. 428-439 ◽  
Author(s):  
David J. Shealy ◽  
Ann Cai ◽  
Kim Staquet ◽  
Audrey Baker ◽  
Eilyn R. Lacy ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Human Monoclonal Antibody ◽  
Human Tumor ◽  
Human Tumor Necrosis Factor ◽  
Factor Α ◽  
Necrosis Factor

Functional characterization of tumor necrosis factor receptor-associated factor 3 of sea perch (Lateolabrax japonicas) in innate immune

2018 ◽  
Vol 75 ◽  
pp. 1-7 ◽  
Author(s):  
Wanwan Zhang ◽  
Peng Jia ◽  
Wei Liu ◽  
Yunlong Li ◽  
Meisheng Yi ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Functional Characterization ◽  
Tumor Necrosis Factor Receptor ◽  
Innate Immune ◽  
Associated Factor ◽  
Sea Perch ◽  
Necrosis Factor
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