A new self-emulsifying drug delivery system (SEDDS) for poorly soluble drugs: Characterization, dissolution, in vitro digestion and incorporation into solid pellets

2008 ◽  
Vol 35 (5) ◽  
pp. 457-464 ◽  
Author(s):  
Ahmed Abdalla ◽  
Sandra Klein ◽  
Karsten Mäder
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Digestion ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble ◽  
Dissolution In Vitro

Development and Characterization of a Self-Nanoemulsifying Drug Delivery System Comprised of Rice Bran Oil for Poorly Soluble Drugs

2019 ◽  
Vol 20 (2) ◽  
Author(s):  
Georgios K. Eleftheriadis ◽  
Panagiota Mantelou ◽  
Christina Karavasili ◽  
Paschalina Chatzopoulou ◽  
Dimitrios Katsantonis ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

An Investigation of the Release Properties of a Cationic Drug From a Hydrophobic Polyanhydride Matrix as a Function of Dissolution Medium

1998 ◽  
Vol 550 ◽  
Author(s):  
E. J. Ginsburg ◽  
T. D. Stultz ◽  
D. A. Stephens ◽  
D. Robinson ◽  
Y. Tian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Anion Exchange ◽  
Polymer Chain ◽  
Delivery System ◽  
In Vitro Release ◽  
Dissolution Medium ◽  
Poorly Soluble ◽  
Vitro Release

AbstractThe dissolution of a drug delivery system consisting of gentamicin sulfate in a hydrophobic polyanhydride matrix has been examined. The in vitro release of gentamicin is a function of the composition of the dissolution medium, with slower release in pH 7.4 buffer than in unbuffered water. This is consistent with an anion exchange taking place under conditions in which carboxylate polymer chain-ends form a poorly soluble salt with gentamicin, and sulfate is released into solution. Results of additional experiments probing this model are digeussed.

scholarly journals Pickering nano-emulsions stabilized by Eudragit RL100 nanoparticles as oral drug delivery system for poorly soluble drugs

2020 ◽  
Vol 191 ◽  
pp. 111010
Author(s):  
Sidy Mouhamed Dieng ◽  
Ziad Omran ◽  
Nicolas Anton ◽  
Oumar Thioune ◽  
Alphonse Rodrigue Djiboune ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Poorly Soluble Drugs ◽  
Oral Drug Delivery System ◽  
Poorly Soluble

scholarly journals Formulation and Characterization of Self-Microemulsifying Drug Delivery System of Tacrolimus

2021 ◽  
Vol 30 (1) ◽  
pp. 91-100
Author(s):  
Duaa J. Al-Tamimi ◽  
Ahmed A. Hussien
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Thermodynamic Stability ◽  
Stability Robustness ◽  
Globule Size ◽  
Poorly Soluble

Abstract The present investigation aimed to formulate a liquid self-microemulsifying drug delivery system (SMEDDS) of tacrolimus to enhance its oral bioavailability by improving its dispersibility and dissolution rate. Four liquid SMEDDS were prepared using maisine CC as oil phase, labrasol ALF as surfactant and transcutol HP as co-surfactant based on the solubility studies of tacrolimus in these components. The phase behavior of the components and the area of microemulsion were evaluated using pseudoternary phase diagrams. The formulations were also assessed for thermodynamic stability, robustness to dilution, self-emulsification time, drug content, globule size and polydispersity index. The prepared SMEDDS formulations exhibited improved drug release compared to the pure drug powder. From this study, it was concluded that using a composition of 10% maisine CC, 67.5% labrasol ALF and 22.5% transcutol produced a liquid SMEDDS with good thermodynamic stability and enhanced in-vitro drug release profiles compared with pure tacrolimus powder. All which supports the use of self-micro emulsifying drug delivery systems as a promising approach to improve solubility, dissolution and stability of poorly soluble drugs like tacrolimus.

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