A NIRS-assisted Test Discriminates Patients with Peripheral Arterial Disease and Chronic Venous Insufficiency with Improved Foot Oxygenation Following Low Elastic Compression Therapy

IntroductionCompression therapy is highly effective in the treatment of many venous diseases, including leg edema. However, its relevance in patients with peripheral arterial disease (PAD) or diabetes mellitus is critically discussed. The aim of the present study was to assess the influence of compression therapy on microperfusion and its safety in patients with PAD or diabetes mellitus.Research design and methodsA prospective analysis of 94 consecutive patients (44 patients with diabetes, 45 patients with PAD and 5 healthy controls) undergoing medical compression therapy was performed. Microperfusion was assessed by a combined method of white light tissue spectrometry and laser Doppler flowmetry under medical compression therapy (classes I and II), in different body positions (supine, sitting, standing and elevated position of the leg) and at different locations (great toe, lateral ankle and calf).ResultsDuring the entire study, no compression-related adverse events occurred. Evaluation of microcirculation parameters (oxygen saturation of hemoglobin and flow) at the different locations and in sitting and standing positions (patients with diabetes and PAD) under compression therapy classes I and II revealed no tendency for reduced microperfusion in both groups. In contrast, in the elevated leg position, all mean perfusion values decreased in the PAD and diabetes groups. However, the same effect was seen in the healthy subgroup.ConclusionsIn consideration of the present inclusion criteria, use of medical compression stockings is safe and feasible in patients with diabetes or PAD. This study did not find relevant impairment of microperfusion parameters under compression therapy in these patient subgroups in physiologic body positions.Trial registration numberNCT03384758.

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Trends on management of superficial venous disease

International Surgery Journal ◽

10.18203/2349-2902.isj20203287 ◽

2020 ◽

Vol 7 (8) ◽

pp. 2820

Author(s):

Shantonu Kumar Ghosh

Keyword(s):

Early Diagnosis ◽

Peripheral Arterial Disease ◽

Venous Thrombosis ◽

Varicose Vein ◽

Venous Insufficiency ◽

Arterial Disease ◽

Venous Disease ◽

Management Options ◽

Regular Work ◽

Peripheral Arterial

Venous disease is more common in the society but less addressed than peripheral arterial disease. This is commonest in people who are sedentary workers, people standing for prolonged period, obase. Usually this group of people do not visit a doctor until it restricts him from regular work, ultimately causing a burden in the community. Early diagnosis of venous disease and its’ management is important. Understanding venous pathology, educating people about disease, conducting awareness program among target group of people are essential. Superficial venous disease includes both venous insufficiency and venous thrombosis. Management options of varicose vein and thrombophlebitis are discussed in the presentation.

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Platelet Lysate and Non-Healing Ulcers

Biointerface Research in Applied Chemistry ◽

10.33263/briac114.1226712274 ◽

2021 ◽

Vol 11 (4) ◽

pp. 12267-12274

Keyword(s):

Peripheral Arterial Disease ◽

Diabetic Foot ◽

Venous Insufficiency ◽

Arterial Disease ◽

Platelet Lysate ◽

Bioactive Molecules ◽

Foot Ulcers ◽

Diabetic Foot Ulcers ◽

Wound Surface ◽

Peripheral Arterial

Platelet lysate contained a wide range of bioactive molecules involved in cell proliferation, migration. The paper analyzes the possibility of using platelet lysate for the treatment of non-healing ulcers. The levels of bioactive molecules were determined by ELISA in platelet lysate. Efficacy of treatment with platelet lysate patients with diabetic foot ulcers, ulcers in patients with peripheral arterial disease and venous insufficiency were analyzed on wound surface area, total epithelialization. Twice injection of platelet lysate with an interval of 5-7 days possess to wound surface area closure on Day 180 at 96% in patients with diabetic foot ulcers, while in patients with peripheral arterial disease and venous insufficiency ulcers wound closure was less. Platelet lysate from patients with non-healing ulcers contained growth factor, cytokine, components of the extracellular matrix, and nitric oxide. Between levels of bioactive molecules in platelet lysate and outcome were found significant correlation. The obtained results indicate that platelet lysate possesses wound healing activity.

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Frequency of peripheral arterial disease and venous insufficiency in toenail onychomycosis

The Journal of Dermatology ◽

10.1111/1346-8138.12020 ◽

2012 ◽

Vol 40 (2) ◽

pp. 107-110 ◽

Cited By ~ 16

Author(s):

Fuat OZKAN ◽

Perihan OZTURK ◽

Kemal OZYURT ◽

Mehmet F. İNCİ ◽

Ali M. KALENDER ◽

...

Keyword(s):

Peripheral Arterial Disease ◽

Venous Insufficiency ◽

Arterial Disease ◽

Peripheral Arterial

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Management of Peripheral Arterial Disease

Internal Medicine News ◽

10.1016/s1097-8690(06)72811-6 ◽

2006 ◽

Vol 39 (3) ◽

pp. 44

Author(s):

WILLIAM E. GOLDEN ◽

ROBERT H. HOPKINS

Keyword(s):

Peripheral Arterial Disease ◽

Arterial Disease ◽

Peripheral Arterial

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Statins Reduced Vascular Events In Peripheral Arterial Disease

Internal Medicine News ◽

10.1016/s1097-8690(06)74124-5 ◽

2006 ◽

Vol 39 (17) ◽

pp. 43

Author(s):

MITCHEL L. ZOLER

Keyword(s):

Peripheral Arterial Disease ◽

Arterial Disease ◽

Vascular Events ◽

Peripheral Arterial

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Abstract #415 Peripheral Arterial Disease and Its Association with Cardiovascular Risk Factors in Type 2 Diabetes

Endocrine Practice ◽

10.1016/s1530-891x(20)47176-9 ◽

2018 ◽

Vol 24 ◽

pp. 103-104

Author(s):

Rohit Kapoor ◽

Shivam Kapoor ◽

Rishabh Kapoor

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Cardiovascular Risk ◽

Peripheral Arterial Disease ◽

Cardiovascular Risk Factors ◽

Arterial Disease ◽

Peripheral Arterial

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High tolerance of progressive elastic compression in peripheral arterial disease

VASA ◽

10.1024/0301-1526/a000799 ◽

2019 ◽

Vol 48 (5) ◽

pp. 413-417 ◽

Cited By ~ 2

Author(s):

Serge Couzan ◽

Jean-François Pouget ◽

Claire Le Hello ◽

Céline Chapelle ◽

Silvy Laporte ◽

...

Keyword(s):

Venous Insufficiency ◽

Ankle Brachial Index ◽

Arterial Disease ◽

Return Flow ◽

High Tolerance ◽

Compression Stockings ◽

Short Term ◽

Poor Tolerance ◽

The Mean ◽

Peripheral Arterial

Summary. Background: Theoretically progressive compression stockings, which produce a higher compression at the calf than at the ankle level, improve venous return flow without exacerbating peripheral arterial insufficiency (PAD). We aimed to evaluate the short-term tolerance of elastic progressive compression stockings on peripheral arterial vascularisation in patients with symptomatic PAD and associated mild venous insufficiency. Patients and methods: Monocentric, prospective, open pilot study of 18 patients (acceptability study, 6 x 6 plan) evaluating the short-term tolerance of progressive compression stockings (18 ± 2 mmHg at calf and 8 ± 2 mmHg at ankle level) in patients with PAD (ankle brachial index ABI > 0.60 < 0.75) and chronic venous insufficiency (C1s–C4 stages of the CEAP classification). Day 15 tolerance was evaluated by a composite primary criteria comprising: no decrease > 15 % of ABI on each side, no decrease > 15 % of toe brachial index (TBI) on each side and no decrease > 25 % of the number of active plantar flexions performed while standing. Results: The proportion of men was 77.8 %, mean age was 77.3 ± 7.5 years and no patient were diabetic. At inclusion, the mean low ABI was 0.60 ± 0.04 and the mean high ABI was 0.77 ± 0.18. The mean low TBI was 0.32 ± 0.09 and the mean high TBI 0.46 ± 0.15. The mean number of active standing plantar flexions was 33.0 ± 5.0. The majority of the patients were classified in CEAP C2s and C3 classes (class 2: 16.7 %, class C2s: 27.8 %, class C3: 44.4 %, class C4: 5.6 % and class C4s: 5.6 %). Poor tolerance occurred in no patient. By day 30, no patient had worsening of their arterial and venous symptoms. No adverse events occurred during the study. Conclusions: These results suggest a high tolerance of progressive elastic stockings (18 ± 2 mmHg at calf and 8 ± 2 mmHg at ankle level) in symptomatic PAD.

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