The history of nuclear energy policy in Italy is characterized by major shifts. After being a world leader in nuclear energy production in the 1960s, the country stopped its programme in the 1980s. An attempt at rejuvenating and expanding nuclear energy in the early 2000s came to an end after the Fukushima disaster. In both instances a referendum was held. Party competition, coalition politics, changes in government, and Italy’s institutional features, in particular the provisions for holding referendums, are the main factors explaining these policy reversals. The chapter concludes that a relaunch of the nuclear energy programme does not seem impossible, but is unlikely for the foreseeable future.