Effect of mood on serum osmolarity: a comparison between manic, depressive and mixed states of bipolar disorder

2019 ◽  
Vol 29 ◽  
pp. S284-S285
Author(s):  
E. Celik ◽  
G. Celikel ◽  
T. Kalelioglu ◽  
N. Karamustafalioglu ◽  
A. Genc ◽  
...  
Author(s):  
Ecem Celik ◽  
Güler Çelikel ◽  
Suat Yalçın ◽  
Tevfik Kalelioglu ◽  
Nesrin Karamustafalioglu

2002 ◽  
Vol 10 (5) ◽  
pp. 255-275 ◽  
Author(s):  
Paola Salvatore ◽  
Ross J. Baldessarini ◽  
Franca Centorrino ◽  
Samy Egli ◽  
Matthew Albert ◽  
...  

1992 ◽  
Vol 9 (1) ◽  
pp. 9-12 ◽  
Author(s):  
Patrick McKeon ◽  
Patrick Manley ◽  
Gregory Swanwick

AbstractThe treatment outcome of 100 bipolar disorder patients (B.P.) was examined retrospectively to determine whether bipolar subtypes had a differential prophylactic response to lithium, carbamazepine, neuroleptics and antidepressant drugs when these treatments were given in a predetermined sequence. Sixty-eight per cent of 53 B.P.-I patients with a mania-depression-normothymic-interval (M.D.I.) sequence of mood changes had a good response to lithium, and all but one of the remainder responded with the addition of carbamazepine or an antidepressant. While only 17% of 12 unipolar manic patients achieved prophylaxis with lithium and a further 17% when carbamazepine was added, the other 66% remained normothymic when a neuroleptic was prescribed with lithium. Of the seven rapid cycling patients where depression preceded mania, 28% had a good prophylactic effect with lithium, a further 28% when a tricyclic antidepressant was added and 14% with lithium and carbamazepine. None of the 18 rapid cycling M.D.I. group had a good response to lithium, but 39% stabilised when carbamazepine was added to lithium. Twenty-eight per cent of this group failed completely to respond to any of the treatments used. Neuroleptics increased the severity and duration of depressive phases for all subtypes except the unipolar mania group.


Author(s):  
Yasser Khazaal ◽  
Sophie Tapparel ◽  
Anne Chatton ◽  
Stephane Rothen ◽  
Martin Preisig ◽  
...  

1970 ◽  
Vol 117 (538) ◽  
pp. 261-266 ◽  
Author(s):  
R. E. Kendell ◽  
Jane Gourlay

The distinction between schizophrenic and affective illnesses has been one of the cornerstones of psychiatric classification ever since Kraepelin introduced the twin concepts of dementia praecox and manic depressive psychosis at the turn of the century. It has also long been recognized that some patients have both schizophrenic and affective symptoms, and various interpretations have been placed on these mixed states. To some continental psychiatrists they constitute a third group of psychoses distinct from both schizophrenia and manic-depressive psychosis—the degeneration psychoses of Kleist or the cycloid psychoses of Leonhard. By others they are regarded as genuine mixed states, with the implication that elements of both schizophrenia and manic depressive illnesses are contributing, perhaps because the genetic or constitutional endowment is mixed, perhaps because two alternative defence mechanisms are being utilized simultaneously. Often, however, mixed symptomatology is simply ignored, either by discounting the schizophrenic symptoms and focusing attention on the mood change, or, as most American psychiatrists do, by glossing over the affective symptoms and regarding the illness as a form of schizophrenia differing in no significant respect from other schizophrenias.


Author(s):  
Max Fink MD

Patients suffering from mania are overactive, intrusive, excited, and belligerent. They may believe that they have special powers, are related to public figures, and can read the minds of others. They spend money lavishly. Voices on the radio or television are sometimes understood as personal communications. They speak rapidly, with illogical and confused thoughts, move constantly, and write page after page of nonsense. They typically sleep and eat poorly, have little interest in work, friends, or family, and often require restraint or seclusion. Suicide is a perpetual threat. Some manic patients are likable, while others are angry and frightening. Psychosis is a frequent feature. Manic patients believe that their parents are not their real parents, asserting that they have royal blood. They believe that they can predict the future. They know that others are watching or talking about them, and they hear voices when no one is present. Delusional mania requires more intensive treatment and almost always hospital care. In older classifications of psychiatric illnesses, these patients were considered to be suffering from a manic-depressive illness. In modern classification, this term has been discarded and the illness is now conceived as bipolar disorder for patients with manic and depressive features and major depression for those with depressive symptoms only. Bipolar disorders, ranging from mild to severe, are divided into numerous subtypes. The variety of symptoms that admit the diagnosis of bipolar disorder has led to a virtual epidemic of diagnoses of the condition. Many patients so labeled do not exhibit the sleep difficulty, loss of appetite, and loss of weight, or the severity of illness, that were the criteria for manic-depressive illness. In manic-depressive illness, the manic episode persists for hours, days, weeks, or months and interferes with normal living. Once the episode resolves, it may suddenly recur; or manic episodes may alternate with periods of depression, or occur as simultaneous mixed episodes of depression and mania. When the shift in mood from mania to depression takes place within one or a few days, the condition is labeled rapid cycling, a particularly malignant form of the illness. In manic-depressive illness, the manic episode persists for hours, days, weeks, or months and interferes with normal living.


2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Luisa Weiner ◽  
Nadège Doignon-Camus ◽  
Gilles Bertschy ◽  
Anne Giersch

Abstract Bipolar disorder (BD) is characterized by speech abnormalities, reflected by symptoms such as pressure of speech in mania and poverty of speech in depression. Here we aimed at investigating speech abnormalities in different episodes of BD, including mixed episodes, via process-oriented measures of verbal fluency performance – i.e., word and error count, semantic and phonological clustering measures, and number of switches–, and their relation to neurocognitive mechanisms and clinical symptoms. 93 patients with BD – i.e., 25 manic, 12 mixed manic, 19 mixed depression, 17 depressed, and 20 euthymic–and 31 healthy controls were administered three verbal fluency tasks – free, letter, semantic–and a clinical and neuropsychological assessment. Compared to depression and euthymia, switching and clustering abnormalities were found in manic and mixed states, mimicking symptoms like flight of ideas. Moreover, the neuropsychological results, as well as the fact that error count did not increase whereas phonological associations did, showed that impaired inhibition abilities and distractibility could not account for the results in patients with manic symptoms. Rather, semantic overactivation in patients with manic symptoms, including mixed depression, may compensate for trait-like deficient semantic retrieval/access found in euthymia. “For those who are manic, or those who have a history of mania, words move about in all directions possible, in a three-dimensional ‘soup’, making retrieval more fluid, less predictable.” Kay Redfield Jamison (2017, p. 279).


1994 ◽  
Vol 165 (6) ◽  
pp. 827-829 ◽  
Author(s):  
R. Littlejohn ◽  
F. Leslie ◽  
J. Cookson

BackgroundThe efficacy of depot antipsychotic drugs in the prophylaxis of bipolar affective disorder was investigated.MethodLife charts were constructed for 18 outpatients with bipolar disorder receiving prophylactic treatment with depot medication. The durations of affective episodes were compared during periods on or off medication.ResultsThe subjects suffered fewer relapses and spent significantly less time in hospital (P = 0.001) for treatment of manic, depressive and mixed affective illness during treatment with depot antipsychotics.ConclusionsDepot antipsychotic medication may be a useful prophylactic treatment for certain patients with bipolar affective disorder.British Journal of Psychiatry (1994), 165, 827–829


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