P.0188 Early life stress targets the transcriptional signature and functional properties of voltage gated-sodium (nav) channels in hippocampal NG2+ GLIA

2021 ◽  
Vol 53 ◽  
pp. S136-S137
Author(s):  
G. Treccani ◽  
H. Yigit ◽  
T. Lingner ◽  
V. Schleuβner ◽  
F. Mey ◽  
...  
Keyword(s):  
Functional Properties ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Voltage Gated ◽  
Transcriptional Signature ◽  
Nav Channels

scholarly journals Early Life Stress Programming of NG2+ Glia Transcriptome Alters Functional Properties of Voltage Gated Sodium (Nav) Channels and Cognitive Performance

2021 ◽  
Vol 89 (9) ◽  
pp. S117-S118
Author(s):  
Giulia Treccani ◽  
Hatice Yigit ◽  
Thomas Lingner ◽  
Vanessa Schleuβner ◽  
Malin Wennström ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Functional Properties ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Voltage Gated ◽  
Nav Channels

scholarly journals Early life stress programming of NG2+ glia transcriptome alters functional properties of voltage gated sodium (Nav) channels and cognitive performance

2020 ◽  
Author(s):  
Giulia Treccani ◽  
Hatice Yigit ◽  
Thomas Lingner ◽  
Vanessa Schleuβner ◽  
Malin Wennström ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Voltage Gated ◽  
Neuronal Populations ◽  
Nav Channels ◽  
Ng2 Cells ◽  
Functional Relevance ◽  
The Impact

AbstractThe precise mechanisms underlying the detrimental effects of early life stress (ELS) on adult mental health remain still elusive. To date, most studies have exclusively targeted neuronal populations and not considered neuron-glia crosstalk as a crucially important element for the integrity of stress-related brain function. Here, we have investigated the impact of ELS on a glial subpopulation with unique properties in brain homeostasis, the NG2+ cells. ELS shifted the NG2+ transcriptome towards more mature stages, and these transcriptional effects were dependent on stress-induced glucocorticoids. The functional relevance of one candidate gene, Scn7a, could be confirmed by an increase in the density of voltage-gated sodium (Nav) channel activated currents in hippocampal NG2+ cells. Scn7a remained upregulated until adulthood in ELS animals, and these same animals displayed impaired cognitive performance. Considering that Nav channels are important for NG2+ cell-to-neuron communication, our findings suggest novel insights into the pathophysiology of stress-related mental disorders.

scholarly journals Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Nav) channels properties

2021 ◽  
pp. 100338
Author(s):  
Giulia Treccani ◽  
Hatice Yigit ◽  
Thomas Lingner ◽  
Vanessa Schleuβner ◽  
Franziska Mey ◽  
...  
Keyword(s):  
Early Life ◽  
Early Life Adversity ◽  
Voltage Gated ◽  
Transcriptional Signature ◽  
Nav Channels

The effects of early life stress on context fear generalization in adult rats.

2019 ◽  
Vol 133 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Nathalie D. Elliott ◽  
Rick Richardson
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Adult Rats ◽  
Fear Generalization

Neurobiology of early life stress: Rodent studies

2002 ◽  
Vol 7 (2) ◽  
pp. 89-95 ◽  
Author(s):  
David A Gutman ◽  
Charles B. Nemeroff
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress

Defining Early Life Stress as a Precursor for Autoimmune Disease

2019 ◽  
Vol 39 (5) ◽  
pp. 329-342
Author(s):  
Jamie Y. Choe ◽  
Maya Nair ◽  
Riyaz Basha ◽  
Byung-Jin Kim ◽  
Harlan P. Jones
Keyword(s):  
Autoimmune Disease ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress
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