P.0539 Fingolimod exerts anxiolytic effect and upregulates genes involved in neuronal survival and amyloid beta metabolism in diabetic mice hippocampus

2021 ◽  
Vol 53 ◽  
pp. S396-S397
Author(s):  
P. Wencel ◽  
K. Blecharz-Klin ◽  
M. Świerczyńska ◽  
A. Piechal ◽  
J. Pyrzanowska ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Neuronal Survival ◽  
Anxiolytic Effect ◽  
Diabetic Mice

Inhibition of Serine Palmitoyltransferase by a Small Organic Molecule Promotes Neuronal Survival after Astrocyte Amyloid Beta 1–42 Injury

2018 ◽  
Vol 10 (3) ◽  
pp. 1627-1635 ◽  
Author(s):  
Teresa De Vita ◽  
Clara Albani ◽  
Natalia Realini ◽  
Marco Migliore ◽  
Abdul Basit ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Organic Molecule ◽  
Neuronal Survival ◽  
Serine Palmitoyltransferase ◽  
Small Organic Molecule

3-n-butylphthalide (NBP) attenuated neuronal autophagy and amyloid-beta expression in diabetic mice subjected to brain ischemia

2011 ◽  
Vol 33 (4) ◽  
pp. 396-404 ◽  
Author(s):  
Ting Zhang ◽  
Weihong Yan ◽  
Qiang Li ◽  
Jianliang Fu ◽  
Kangyong Liu ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Brain Ischemia ◽  
Diabetic Mice ◽  
Neuronal Autophagy

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

2002 ◽  
Vol 38 ◽  
pp. 37-49 ◽  
Author(s):  
Janelle Nunan ◽  
David H Small
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Alternative Pathway ◽  
Protein A ◽  
Proteolytic Processing ◽  
Gamma Secretase ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Amyloid Beta Protein Precursor

The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving beta- and gamma-secretase, liberates amyloid-beta protein, a protein associated with the neurodegeneration seen in Alzheimer's disease. The alternative pathway, involving alpha-secretase, precludes amyloid-beta protein formation. In this review, we describe the progress that has been made in identifying the secretases and their potential as therapeutic targets in the treatment or prevention of Alzheimer's disease.

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