IGF-I ameliorates hippocampal neurodegeneration and protects against cognitive deficits in an animal model of temporal lobe epilepsy

2011 ◽  
Vol 231 (2) ◽  
pp. 223-235 ◽  
Author(s):  
Panagiota Miltiadous ◽  
Antonios Stamatakis ◽  
Paraskevi N. Koutsoudaki ◽  
Dina G. Tiniakos ◽  
Fotini Stylianopoulou
Keyword(s):  
Animal Model ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Cognitive Deficits ◽  
Igf I ◽  
Hippocampal Neurodegeneration

Evaluation of dynamic scaling of growing interfaces in EEG fluctuations of seizures in animal model of temporal lobe epilepsy

2017 ◽  
Vol 88 ◽  
pp. 41-49
Author(s):  
Claudia Lizbeth Martínez-González ◽  
Alexander Balankin ◽  
Tessy López ◽  
Joaquín Manjarrez-Marmolejo ◽  
Efraín José Martínez-Ortiz
Keyword(s):  
Animal Model ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Dynamic Scaling

scholarly journals An investigation of EEG dynamics in an animal model of temporal lobe epilepsy using the maximum Lyapunov exponent

2009 ◽  
Vol 216 (1) ◽  
pp. 115-121 ◽  
Author(s):  
Sandeep P. Nair ◽  
Deng-Shan Shiau ◽  
Jose C. Principe ◽  
Leonidas D. Iasemidis ◽  
Panos M. Pardalos ◽  
...  
Keyword(s):  
Animal Model ◽  
Lyapunov Exponent ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Maximum Lyapunov Exponent

Non-parametric early seizure detection in an animal model of temporal lobe epilepsy

2008 ◽  
Vol 5 (1) ◽  
pp. 85-98 ◽  
Author(s):  
Sachin S Talathi ◽  
Dong-Uk Hwang ◽  
Mark L Spano ◽  
Jennifer Simonotto ◽  
Michael D Furman ◽  
...  
Keyword(s):  
Animal Model ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Seizure Detection ◽  
Early Seizure ◽  
Non Parametric

Animal models of status epilepticus and temporal lobe epilepsy: a narrative review

2018 ◽  
Vol 29 (7) ◽  
pp. 757-770 ◽  
Author(s):  
Nikita Nirwan ◽  
Preeti Vyas ◽  
Divya Vohora
Keyword(s):  
Animal Model ◽  
Status Epilepticus ◽  
Animal Models ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Current Literature ◽  
Clinical Characteristics ◽  
Genetic Models ◽  
Suitable Animal Model ◽  
Effective Models

Abstract Temporal lobe epilepsy (TLE) is the chronic and pharmacoresistant form of epilepsy observed in humans. The current literature is insufficient in explicating the comprehensive mechanisms underlying its pathogenesis and advancement. Consequently, the development of a suitable animal model mimicking the clinical characteristics is required. Further, the relevance of status epilepticus (SE) to animal models is dubious. SE occurs rarely in people; most epilepsy patients never experience it. The present review summarizes the established animal models of SE and TLE, along with a brief discussion of the animal models that have the distinctiveness and carries the possibility to be developed as effective models for TLE. The review not only covers the basic requirements, mechanisms, and methods of induction of each model but also focuses upon their major limitations and possible modifications for their future use. A detailed discussion on chemical, electrical, and hypoxic/ischemic models as well as a brief explanation on the genetic models, most of which are characterized by development of SE followed by neurodegeneration, is presented.

Baicalein improves cognitive deficits and hippocampus impairments in temporal lobe epilepsy rats

2019 ◽  
Vol 1714 ◽  
pp. 111-118 ◽  
Author(s):  
Xu Qian ◽  
Zhao-Rui Wang ◽  
Jing-Jun Zheng ◽  
Ji-Qiang Ding ◽  
Jia-Gui Zhong ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Cognitive Deficits

Temporal lobe epilepsy and social behavior: An animal model for autism?

2008 ◽  
Vol 13 (1) ◽  
pp. 43-46 ◽  
Author(s):  
Joao Carlos M. Marin ◽  
Paula J. Moura ◽  
Roberta M. Cysneiros ◽  
Diego B. Colugnati ◽  
Esper A. Cavalheiro ◽  
...  
Keyword(s):  
Animal Model ◽  
Social Behavior ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe

scholarly journals Effect of spontaneous seizures on GABAAreceptor α4 subunit expression in an animal model of temporal lobe epilepsy

Epilepsia ◽  
2014 ◽  
Vol 55 (11) ◽  
pp. 1826-1833 ◽  
Author(s):  
Heidi L Grabenstatter ◽  
Meaghan Cogswell ◽  
Yasmin Cruz Del Angel ◽  
Jessica Carlsen ◽  
Marco I. Gonzalez ◽  
...  
Keyword(s):  
Animal Model ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Spontaneous Seizures ◽  
Subunit Expression

Executive functions in children with frontal and temporal lobe epilepsy

2002 ◽  
Vol 8 (5) ◽  
pp. 623-632 ◽  
Author(s):  
Kathleen Culhane-Shelburne ◽  
Lynn Chapieski ◽  
Merrill Hiscock ◽  
Daniel Glaze
Keyword(s):  
Executive Functioning ◽  
Temporal Lobe Epilepsy ◽  
Executive Functions ◽  
Temporal Lobe ◽  
Cognitive Deficits ◽  
Adaptive Functioning ◽  
Seizure Type ◽  
Opposite Pattern ◽  
Nonverbal Memory ◽  
Psychometric Studies

AbstractEven though frontal lobe epilepsy (FLE) is a relatively common seizure type, no formal psychometric studies of children with FLE have been reported. We compared 12 children with FLE and 15 children with temporal lobe epilepsy (TLE) on neuropsychological tests of attention, memory, executive functioning, and adaptive functioning. The results of these tests indicated that the children with FLE had deficits in planning and executive functions, whereas their verbal and nonverbal memory was intact. The opposite pattern was observed in children with TLE. Measures of executive functioning and impulse control were the best predictors of adaptive functioning. The findings suggest that children with FLE have a pattern of cognitive deficits that differs markedly from the pattern seen in children with TLE. Children with FLE have prominent deficits in executive functioning that appear to be related to poor behavioral adaptation.

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