scholarly journals Deep brain stimulation improves behavior and modulates neural circuits in a rodent model of schizophrenia

2016 ◽  
Vol 283 ◽  
pp. 142-150 ◽  
Author(s):  
Lior Bikovsky ◽  
Ravit Hadar ◽  
María Luisa Soto-Montenegro ◽  
Julia Klein ◽  
Ina Weiner ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Neural Circuits ◽  
Rodent Model ◽  
Deep Brain

EP 18. Deep Brain Stimulation improves behavior and modulates neural circuits in a rodent model of schizophrenia

2016 ◽  
Vol 127 (9) ◽  
pp. e182
Author(s):  
R. Hadar ◽  
L. Bikovsky ◽  
M. Soto-Montenegro ◽  
J. Klein ◽  
I. Weiner ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Neural Circuits ◽  
Rodent Model ◽  
Deep Brain

Psychiatric neurosurgery

2018 ◽  
pp. 135-184
Author(s):  
Walter Glannon
Keyword(s):  
Clinical Trials ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Neural Circuits ◽  
Therapeutic Potential ◽  
Genetic Material ◽  
Research Subjects ◽  
Ethical Justification ◽  
The Brain ◽  
Deep Brain

This chapter discusses functional neurosurgery designed to modulate dysfunctional neural circuits mediating sensorimotor, cognitive, emotional, and volitional capacities. The chapter assesses the comparative benefits and risks of neural ablation and deep brain stimulation as the two most invasive forms of neuromodulation. It discusses the question of whether individuals with a severe or moderately severe psychiatric disorder have enough cognitive and emotional capacity to weigh reasons for and against ablation or deep brain stimulation and give informed consent to undergo it. The chapter also discusses the obligations of investigators conducting these trials to research subjects. In addition, it examines the medical and ethical justification for a sham control arm in psychiatric neurosurgery clinical trials. It considers the therapeutic potential of optogenetics as a novel form of neuromodulation. The fact that this technique manipulates both genetic material and neural circuits and has been tested only in animal models makes it unclear what its benefit–risk ratio would be. The chapter concludes with a brief discussion of the potential of neuromodulation to stimulate endogenous repair and growth mechanisms in the brain.

scholarly journals Evoked potentials reveal neural circuits engaged by human deep brain stimulation

2020 ◽  
Vol 13 (6) ◽  
pp. 1706-1718
Author(s):  
Stephen L. Schmidt ◽  
David T. Brocker ◽  
Brandon D. Swan ◽  
Dennis A. Turner ◽  
Warren M. Grill
Keyword(s):  
Deep Brain Stimulation ◽  
Evoked Potentials ◽  
Brain Stimulation ◽  
Neural Circuits ◽  
Deep Brain

scholarly journals Chronic deep brain stimulation of the medial forebrain bundle reverses depressive-like behavior in a hemiparkinsonian rodent model

2015 ◽  
Vol 233 (11) ◽  
pp. 3073-3085 ◽  
Author(s):  
Luciano L. Furlanetti ◽  
Volker A. Coenen ◽  
Iñigo A. Aranda ◽  
Máté D. Döbrössy
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Medial Forebrain Bundle ◽  
Rodent Model ◽  
Deep Brain ◽  
Stimulation Of
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