Parkinsonism and subthalamic deep brain stimulation dysregulate behavioral motivation in a rodent model

2020 ◽  
Vol 1736 ◽  
pp. 146776 ◽  
Author(s):  
Collin Anderson ◽  
Daylan Sheppard ◽  
Alan D. Dorval
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Rodent Model ◽  
Behavioral Motivation ◽  
Deep Brain

scholarly journals Chronic deep brain stimulation of the medial forebrain bundle reverses depressive-like behavior in a hemiparkinsonian rodent model

2015 ◽  
Vol 233 (11) ◽  
pp. 3073-3085 ◽  
Author(s):  
Luciano L. Furlanetti ◽  
Volker A. Coenen ◽  
Iñigo A. Aranda ◽  
Máté D. Döbrössy
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Medial Forebrain Bundle ◽  
Rodent Model ◽  
Deep Brain ◽  
Stimulation Of

scholarly journals Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia

2013 ◽  
Vol 16 (6) ◽  
pp. 1331-1339 ◽  
Author(s):  
Stephanie M. Perez ◽  
Amiksha Shah ◽  
Amber Asher ◽  
Daniel J. Lodge
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Rodent Model ◽  
Neuron Activity ◽  
Positive Symptoms ◽  
Dopamine System ◽  
Novel Approach ◽  
Hippocampal Activity ◽  
Unique Approach ◽  
Deep Brain

Abstract Subcortical dopamine system dysregulation has been suggested to underlie the positive symptoms of schizophrenia. Recent preclinical investigations and human imaging studies have proposed that the augmented dopamine system function observed in schizophrenia patients may be secondary to aberrant hippocampal activity. Thus, we posit that the hippocampus represents a novel therapeutic target for the treatment of schizophrenia. Here we provide evidence of the effectiveness of a unique approach aimed at decreasing hippocampal function in a rodent model of schizophrenia. Specifically, in a rodent model of schizophrenia, we demonstrate that ventral hippocampal (vHipp) deep brain stimulation (DBS) can normalize aberrant dopamine neuron activity and behaviours associated with positive symptoms. In addition, we provide evidence that this approach may also be effective in restoring deficits in cognitive function, often left unaltered by conventional antipsychotic medications. Therefore, we have provided initial preclinical evidence demonstrating the feasibility of hippocampal DBS as a potential novel approach for the treatment of schizophrenia.

EP 18. Deep Brain Stimulation improves behavior and modulates neural circuits in a rodent model of schizophrenia

2016 ◽  
Vol 127 (9) ◽  
pp. e182
Author(s):  
R. Hadar ◽  
L. Bikovsky ◽  
M. Soto-Montenegro ◽  
J. Klein ◽  
I. Weiner ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Neural Circuits ◽  
Rodent Model ◽  
Deep Brain

scholarly journals Deep brain stimulation improves behavior and modulates neural circuits in a rodent model of schizophrenia

2016 ◽  
Vol 283 ◽  
pp. 142-150 ◽  
Author(s):  
Lior Bikovsky ◽  
Ravit Hadar ◽  
María Luisa Soto-Montenegro ◽  
Julia Klein ◽  
Ina Weiner ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Neural Circuits ◽  
Rodent Model ◽  
Deep Brain
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