The GluN1/GluN2B NMDA receptor and metabotropic glutamate receptor 1 negative allosteric modulator has enhanced neuroprotection in a rat subarachnoid hemorrhage model

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Metabotropic Glutamate Receptor 1 ◽

Population Pharmacokinetic and Exposure-dizziness Modeling for a Metabotropic Glutamate Receptor Subtype 5 Negative Allosteric Modulator in Major Depressive Disorder Patients

Clinical and Translational Science ◽

10.1111/cts.12566 ◽

2018 ◽

Vol 11 (5) ◽

pp. 523-531

Author(s):

Valérie Cosson ◽

Franziska Schaedeli-Stark ◽

Mona Arab-Alameddine ◽

Clarisse Chavanne ◽

Elena Guerini ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Glutamate Receptor ◽

Population Pharmacokinetic ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Major Depressive ◽

Metabotropic Glutamate ◽

Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator

Psychopharmacology ◽

10.1007/s00213-012-2804-z ◽

2012 ◽

Vol 225 (1) ◽

pp. 151-159 ◽

Cited By ~ 23

Author(s):

Lucas R. Watterson ◽

Peter R. Kufahl ◽

Natali E. Nemirovsky ◽

Kaveish Sewalia ◽

Lauren E. Hood ◽

...

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Seeking Behavior ◽

Negative Allosteric Modulator ◽

Food Seeking

Effects of a novel metabotropic glutamate receptor 7 negative allosteric modulator, 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo[4,5-c]pyridin-4(5H)-one (MMPIP), on the central nervous system in rodents

European Journal of Pharmacology ◽

10.1016/j.ejphar.2009.08.047 ◽

2010 ◽

Vol 639 (1-3) ◽

pp. 106-114 ◽

Cited By ~ 25

Author(s):

Hirohiko Hikichi ◽

Takeshi Murai ◽

Shoki Okuda ◽

Shunsuke Maehara ◽

Akio Satow ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Glutamate Receptor ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

The Central Nervous System ◽

Correction to “ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and In Vivo Characterization”

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.112.05er13b ◽

2013 ◽

Vol 345 (2) ◽

pp. 328-328

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator ◽

In Vivo Characterization

The metabotropic glutamate receptor 5 negative allosteric modulator fenobam

Pain ◽

10.1097/j.pain.0000000000001695 ◽

2020 ◽

Vol 161 (1) ◽

pp. 135-146 ◽

Cited By ~ 1

Author(s):

Laura F. Cavallone ◽

Michael C. Montana ◽

Karen Frey ◽

Dorina Kallogjeri ◽

James M. Wages ◽

...

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Basimglurant for treatment of major depressive disorder: a novel negative allosteric modulator of metabotropic glutamate receptor 5

Expert Opinion on Investigational Drugs ◽

10.1517/13543784.2015.1074175 ◽

2015 ◽

Vol 24 (9) ◽

pp. 1247-1260 ◽

Cited By ~ 25

Author(s):

Kjell Fuxe ◽

Dasiel O Borroto-Escuela

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Glutamate Receptor ◽

Allosteric Modulator ◽

Major Depressive ◽

Metabotropic Glutamate ◽

Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.7b00098 ◽

2017 ◽

Vol 8 (9) ◽

pp. 1937-1948 ◽

Cited By ~ 14

Author(s):

Xiaofei Zhang ◽

Katsushi Kumata ◽

Tomoteru Yamasaki ◽

Ran Cheng ◽

Akiko Hatori ◽

...

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Efficacy, tolerability and pharmacokinetics of a modified release formulation of ADX10059, a negative allosteric modulator of metabotropic glutamate receptor 5: an esophageal pH-impedance study in healthy subjects

Neurogastroenterology & Motility ◽

10.1111/j.1365-2982.2010.01484.x ◽

2010 ◽

Vol 22 (8) ◽

pp. 859-e231 ◽

Cited By ~ 32

Author(s):

F. Zerbib ◽

C. Keywood ◽

G. Strabach

Keyword(s):

Glutamate Receptor ◽

Healthy Subjects ◽

Allosteric Modulator ◽

Modified Release ◽

Release Formulation ◽

Metabotropic Glutamate ◽

Esophageal Ph ◽

Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b01858 ◽

2017 ◽

Vol 60 (6) ◽

pp. 2470-2484 ◽

Cited By ~ 12

Author(s):

János Galambos ◽

Attila Bielik ◽

Mikhail Krasavin ◽

Zoltán Orgován ◽

György Domány ◽

...

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

ADX71743, a Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.112.0313hib ◽

2013 ◽

Vol 344 (3) ◽

pp. 543.3-543

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽