Genetic disruption of the nuclear receptor Nur77 (Nr4a1) in rat reduces dopamine cell loss and l-Dopa-induced dyskinesia in experimental Parkinson's disease

Abstract Parkinson’s disease is characterized by dopamine cell loss of the substantia nigra. Parkinson’s disease and the neurotoxin 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine may destroy dopamine neurons through oxidative stress. Coenzyme Q is a cofactor of mitochondrial uncoupling proteins that enhances state-4 respiration and eliminate superoxides. Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys.

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Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease

Neurobiology of Disease ◽

10.1016/j.nbd.2016.01.016 ◽

2016 ◽

Vol 89 ◽

pp. 55-64 ◽

Cited By ~ 19

Author(s):

Ludovico Arcuri ◽

Riccardo Viaro ◽

Simone Bido ◽

Francesco Longo ◽

Mariangela Calcagno ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cell Loss ◽

Orphanin Fq ◽

Dopamine Cell

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Faculty Opinions recommendation of Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717953615.793459220 ◽

2012 ◽

Author(s):

Patrik Brundin ◽

Jennifer Steiner

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Transcription Factor ◽

Nuclear Receptor ◽

Dopaminergic Neurons ◽

Midbrain Dopaminergic Neurons ◽

Conditional Expression ◽

Progressive Neurodegeneration

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Faculty Opinions recommendation of Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.733700001.793551488 ◽

2018 ◽

Author(s):

Vladimir Uversky

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Mouse Model ◽

Cell Loss ◽

Synapsin Iii

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Dopamine cell transplantation in Parkinson's disease: challenge and perspective

British Medical Bulletin ◽

10.1093/bmb/ldr040 ◽

2011 ◽

Vol 100 (1) ◽

pp. 173-189 ◽

Cited By ~ 14

Author(s):

Yilong Ma ◽

Shichun Peng ◽

Vijay Dhawan ◽

David Eidelberg

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cell Transplantation ◽

Dopamine Cell

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Parkinsonism, Parkinson’s disease, and related conditions

Oxford Textbook of Geriatric Medicine ◽

10.1093/med/9780198701590.003.0116 ◽

2017 ◽

pp. 897-906

Author(s):

John V. Hindle ◽

Sion Jones ◽

Glesni Davies

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Older People ◽

Lewy Bodies ◽

Cell Loss ◽

Brain Regions ◽

Motor Symptoms ◽

Advanced Care Planning ◽

Non Motor Symptoms

Parkinson’s disease (PD) is a progressive neurodegenerative condition characterized clinically by fatiguable bradykinesia, rigidity and tremor and pathologically by deposition of Lewy bodies and cell loss in the substantia nigra and other brain regions. Parkinsonism is the term used to describe the clinical features of conditions resembling PD. Their management requires specialist assessment and a multidisciplinary approach. Levodopa remains the mainstay of treatment for PD. Although other treatments are used, older people are more sensitive to their side effects. Non-motor symptoms, particularly neuropsychiatric problems, significantly impact quality of life and need special consideration in older people. Towards the later stage of the disease, management can be complex, and should involve advanced care planning.

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