Spatiotemporal dynamic changes, proliferation, and differentiation characteristics of Sox9-positive cells after severe complete transection spinal cord injury

2021 ◽  
Vol 337 ◽  
pp. 113556
Author(s):  
Haipeng Zhang ◽  
Weiwei Xue ◽  
Xiaoyu Xue ◽  
Yongheng Fan ◽  
Yaming Yang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Dynamic Changes ◽  
Spatiotemporal Dynamic ◽  
Complete Transection ◽  
Cord Injury ◽  
Proliferation And Differentiation

scholarly journals Induction of Complete Transection-Type Spinal Cord Injury in Mice

10.3791/61131 ◽  
2020 ◽  
Author(s):  
Ronak Reshamwala ◽  
Tanja Eindorf ◽  
Megha Shah ◽  
Graham Smyth ◽  
Todd Shelper ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Complete Transection ◽  
Cord Injury

Agmatine-Reduced Collagen Scar Area Accompanied With Surface Righting Reflex Recovery After Complete Transection Spinal Cord Injury

Spine ◽  
2011 ◽  
Vol 36 (25) ◽  
pp. 2130-2138 ◽  
Author(s):  
Jae Hwan Kim ◽  
Yong Woo Lee ◽  
Yu Mi Park ◽  
Kyung Ah Park ◽  
Seung Hwa Park ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Scar Area ◽  
Complete Transection ◽  
Cord Injury ◽  
Righting Reflex

scholarly journals Dynamic changes in the systemic immune responses of spinal cord injury model mice

2021 ◽  
Vol 16 (2) ◽  
pp. 382
Author(s):  
Bin Wang ◽  
Tian-Yun Gao ◽  
Fei-Fei Huang ◽  
Yuan-Yuan Xie ◽  
Wen-Qing Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Immune Responses ◽  
Dynamic Changes ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Cord Injury

scholarly journals MicroRNA-219 Inhibits Proliferation and Induces Differentiation of Oligodendrocyte Precursor Cells after Contusion Spinal Cord Injury in Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Fang Li ◽  
Mou-Wang Zhou ◽  
Nan Liu ◽  
Yan-Yan Yang ◽  
Hua-Yi Xing ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Precursor Cells ◽  
Blue Staining ◽  
Oligodendrocyte Precursor Cells ◽  
Monocarboxylate Transporter 1 ◽  
Cord Injury ◽  
Proliferation And Differentiation ◽  
Oligodendrocyte Precursor

MicroRNA-219 (miR-219) regulates the proliferation and differentiation of oligodendrocyte precursor cells (OPCs) during central nervous system (CNS) development. OPCs only differentiate into oligodendrocytes (OLs) in the healthy CNS, but can generate astrocytes (As) after injury. We hypothesized that miR-219 may modulate OPC proliferation and differentiation in a cervical C5 contusion spinal cord injury (SCI) model. After injury, we observed a decrease in the miR-219 level and quantity of OLs and an increase in the number of OPCs and As. Silencing of miR-219 by its antagomir in vivo produced similar results, but of greater magnitude. Overexpression of miR-219 by its agomir in vivo increased the number of OLs and suppressed generation of OPCs and As. Luxol fast blue staining confirmed that SCI caused demyelination and that the extent of demyelination was attenuated by miR-219 overexpression, but aggravated by miR-219 reduction. Monocarboxylate transporter 1 (MCT-1) may be implicated in the regulation of OPC proliferation and differentiation mediated by miR-219 following contusion SCI. Collectively, our data suggest that miR-219 may mediate SCI-induced OPC proliferation and differentiation, and MCT-1 may participate in this process as a target of miR-219.

A novel hydrogel-based treatment for complete transection spinal cord injury repair is driven by microglia/macrophages repopulation

Biomaterials ◽  
2020 ◽  
Vol 237 ◽  
pp. 119830 ◽  
Author(s):  
Dezun Ma ◽  
Yannan Zhao ◽  
Lei Huang ◽  
Zhifeng Xiao ◽  
Bing Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Injury Repair ◽  
Complete Transection ◽  
Cord Injury

Transplanting neural progenitors into a complete transection model of spinal cord injury

2014 ◽  
Vol 92 (5) ◽  
pp. 607-618 ◽  
Author(s):  
Carla Christina Medalha ◽  
Ying Jin ◽  
Takaya Yamagami ◽  
Christopher Haas ◽  
Itzhak Fischer
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neural Progenitors ◽  
Complete Transection ◽  
Cord Injury

scholarly journals Dynamic changes in intramedullary pressure 72 hours after spinal cord injury

2019 ◽  
Vol 14 (5) ◽  
pp. 886 ◽  
Author(s):  
Ming-Liang Yang ◽  
Jian-Jun Li ◽  
Xin Zhang ◽  
Chang-Bin Liu ◽  
De-Gang Yang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Dynamic Changes ◽  
Intramedullary Pressure ◽  
Cord Injury

Research on Differentiation of Bone Marrow Stromal Cells (BMSCs) Prompted by MicroRNA-124 and Effect on Inflammatory Reaction of Spinal Cord Injury Nerve Cells

2022 ◽  
Vol 12 (3) ◽  
pp. 588-596
Author(s):  
Ming Xu ◽  
Guo Yong Tan ◽  
Xian Ming Tao
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mechanical Damage ◽  
Nerve Cells ◽  
Sod Activity ◽  
Cord Injury ◽  
Proliferation And Differentiation ◽  
Microrna 124 ◽  
Apoptotic Activity ◽  
And Oxidative Stress

The major feature of spinal cord injury (SCI) was the damage of nervous tissue in spinal cord. The damaged spinal cord was difficult to be repaired and regenerated. MicroRNA-124 could play a role in the repairing and recovering the injured tissue. The BMSCs could participate in repairing the damage. However, the regulatory effect of MicroRNA-124 on BMSCs and the inflammatory response of SCI was still not illustrated. These spinal cord nerve cells were assigned into group of mechanical damage, BMSCs and BMSCs with miR-124 overexpression followed by analysis of proliferation of nerve cells by MTT assay, apoptotic activity, expression of miR-124, GFAP and BDNF by Real time PCR, levels of TNF-α and IL-6 by ELISA as well as MDH and SOD activity. miR-124 mimics transfection significantly promoted BMSCs proliferation and increased ALK activity and the expression of GFAP and BDNF. In conclusion, the proliferation and differentiation of BMSCs could be regulated by miR-124. The inflammation and oxidative stress could be restrained so as to prompt the proliferation and repair of SCI cells and restrain apoptosis, indicating that it might be beneficial to recover the SCI.

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