Application of food and feed safety assessment principles to evaluate transgenic approaches to gene modulation in crops

2010 ◽  
Vol 48 (7) ◽  
pp. 1773-1790 ◽  
Author(s):  
Wayne Parrott ◽  
Bruce Chassy ◽  
Jim Ligon ◽  
Linda Meyer ◽  
Jay Petrick ◽  
...  
Author(s):  
Hanspeter Naegeli ◽  
Gijs Klete ◽  
Antje Dietz-Pfeilstetter

Abstract This paper evaluates the potential hazards of food and feed derived from RNAi plants including: adverse changes of plant metabolism; mechanisms and potential for non-target gene silencing in humans and livestock, including gut microbiome; bioinformatics tools for predictionof off-target sequences of interfering RNA; the possible non-specific effects of dsRNA and siRNA in mammals; and the comparison of data requirements for safety assessment of food and feed from RNAi plants and from plants expressing recombinant proteins. It also discusses exposure and RNAi-specific risk assessment.


TOS forum ◽  
2015 ◽  
Vol 2013 (1) ◽  
pp. 51
Author(s):  
C. C. Paoletti ◽  
K. Esbensen ◽  
H. Kuiper

Author(s):  
Hanspeter Naegeli ◽  
Gijs Klete ◽  
Antje Dietz-Pfeilstetter

Abstract This paper evaluates the potential hazards of food and feed derived from RNAi plants including: adverse changes of plant metabolism; mechanisms and potential for non-target gene silencing in humans and livestock, including gut microbiome; bioinformatics tools for predictionof off-target sequences of interfering RNA; the possible non-specific effects of dsRNA and siRNA in mammals; and the comparison of data requirements for safety assessment of food and feed from RNAi plants and from plants expressing recombinant proteins. It also discusses exposure and RNAi-specific risk assessment.


Food Control ◽  
2019 ◽  
Vol 98 ◽  
pp. 9-18 ◽  
Author(s):  
Arjen Gerssen ◽  
Toine H.F. Bovee ◽  
Leendert A. van Ginkel ◽  
Marlou L.P.S. van Iersel ◽  
Ron L.A.P. Hoogenboom

Author(s):  
Griffiths Atungulu ◽  
Zeinab Mohammadi-Shad

Mycotoxins are a group of naturally occurring toxins that are produced by different filamentous fungi genera such as Aspergillus, Penicillium, Fusarium, etc. The word mycotoxin literally is derived from Greek word “myke” meaning fungus and “toxicum” meaning toxin. These contaminants can develop on different food and feed commodities during different stages including pre-harvest, harvest, and storage. Mycotoxins are of concern because their outbreak result in animal and human diseases and economic losses. It has been estimated that global post-harvest losses are approximately at 50%. Human exposure to mycotoxins is typically through consumption of contaminated agricultural products or indirectly by consumption of animal products containing mycotoxins or their metabolites. The chapter provides the latest information on mycotoxin issues and challenges related to food and feed safety.


2018 ◽  
Vol 94 ◽  
pp. 70-74 ◽  
Author(s):  
Rod A. Herman ◽  
Ricardo D. Ekmay ◽  
Barry W. Schafer ◽  
Ping Song ◽  
Brandon J. Fast ◽  
...  

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