Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study

2006 ◽  
Vol 85 (6) ◽  
pp. 1774-1777 ◽  
Author(s):  
B JEE ◽  
S KU ◽  
C SUH ◽  
K KIM ◽  
W LEE ◽  
...  
Keyword(s):  
Pilot Study ◽  
Intrauterine Insemination ◽  
Clomiphene Citrate

scholarly journals Women’s Reports of Barriers to and Facilitators of Oral Medication Adherence During Ovarian Stimulation: A Mixed Methods Pilot Study

2021 ◽  
Author(s):  
Diane E. Mahoney ◽  
Cynthia L. Russell
Keyword(s):  
Mixed Methods ◽  
Medication Adherence ◽  
Pilot Study ◽  
Ovarian Stimulation ◽  
Lifestyle Modification ◽  
Intrauterine Insemination ◽  
Clomiphene Citrate ◽  
Oral Medication ◽  
Fertility Treatment ◽  
Daily Routine

Background: Adherence to lifestyle modification recommendations remains problematic for women undergoing fertility treatment, raising concerns about the extent to which women adhere to prescribed medication regimens. Limited data have shown suboptimal oral medication adherence rates of 19% to 74%. The objective of this study was to explore what women perceive as barriers to and facilitators of oral medication adherence during fertility treatment cycles. Methods: An exploratory mixed methods pilot study was conducted among a sample of 30 women who were actively taking one to two cycles of letrozole or clomiphene citrate for ovarian stimulation in conjunction with intrauterine insemination cycles. Medication adherence barriers were measured using a 20-item survey. Medication adherence facilitators and personal experiences with fertility treatment were assessed with structured interviews. Medication adherence was assessed with electronic event monitoring.  Results: The overall medication adherence median was 0.97 with a range of 0.75 to 1.00, and nine women (50%) demonstrated perfect adherence. The most commonly reported barriers were recently feeling sad, down, or blue (53%), and taking medication more than once per day (40%). Women with higher barrier scores had significantly lower medication adherence scores (p=0.02) compared to women with lower total barrier scores. Facilitators included using physical aides as reminders (60%) and establishing a daily routine (50%). No significant correlation was found between medication adherence scores and facilitators.  Conclusion: The dynamic interplay between perceived barriers and facilitators and women’s medication-taking patterns could influence whether or not medication regimens are followed correctly.

Clomiphene citrate challenge test predicts outcome of intrauterine insemination in women aged under 37 years

2006 ◽  
Vol 12 (4) ◽  
pp. 423-427 ◽  
Author(s):  
Amiram Magendzo ◽  
Juan-Enrique Schwarze ◽  
Claudia Diaz de la Vega ◽  
Elena Altieri ◽  
Fernando Zegers-Hochschild ◽  
...  
Keyword(s):  
Intrauterine Insemination ◽  
Clomiphene Citrate ◽  
Challenge Test

scholarly journals Effect of repeated administration of clomiphene citrate at two different times on the endometrium in patients undergoing intrauterine insemination

2004 ◽  
Vol 3 (3) ◽  
pp. 153-157
Author(s):  
MAMIKO WADA ◽  
TSUYOSHI KASAI ◽  
SEIICHIRO NAGAI ◽  
MICHIKO FUJIE ◽  
MAKI MIYAKE ◽  
...  
Keyword(s):  
Intrauterine Insemination ◽  
Clomiphene Citrate ◽  
Repeated Administration

P-230 Intrauterine insemination: Clomiphene citrate does not increase the pregnancy rate

1997 ◽  
Vol 68 ◽  
pp. S201-S202
Author(s):  
G.L Kroll ◽  
D.E Moore ◽  
E.M Moore ◽  
N.A Klein ◽  
M.R Soules ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Intrauterine Insemination ◽  
Clomiphene Citrate

A Randomized Clinical Trial to Evaluate Optimal Treatment for Unexplained Infertility

2021 ◽  
pp. 246-250
Author(s):  
Stephanie Rothenberg ◽  
Joseph Sanfilippo
Keyword(s):  
Ovulation Induction ◽  
Treatment Approach ◽  
Intrauterine Insemination ◽  
Clomiphene Citrate ◽  
Unexplained Infertility ◽  
Additional Benefit ◽  
Multiple Gestation ◽  
Time To Pregnancy ◽  
Vitro Fertilization

The treatment of unexplained infertility has traditionally been comprised of a stepwise treatment approach, first with ovulation induction combined with intrauterine insemination (IUI) and then with in vitro fertilization (IVF). Ovulation induction is first attempted with clomiphene citrate, and, if unsuccessful, injectable gonadotropins are used. The value of ovulation induction with injectable gonadotropins in couples with unexplained infertility has been questioned, however, given the high risk of multiple gestation and the increasing efficacy of IVF. To address this, the FASTT trial randomized couples with unexplained infertility to a treatment arm that either included or omitted gonadotropin/IUI. They found that an accelerated treatment approach that involved 3 cycles of clomiphene citrate/IUI and then progressed immediately to IVF resulted in a decreased time to pregnancy compared to the group who underwent gonadotropin/IUI for 3 cycles, as well as decreased cost per live birth. Therefore, it was concluded that treatment of couples with unexplained infertility with gonadotropin/IUI was of no additional benefit.

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