Alleles and haplotypes of the estrogen receptor alpha gene are associated with an increased risk of spontaneous abortion

2010 ◽  
Vol 93 (6) ◽  
pp. 1809-1815 ◽  
Author(s):  
Begoña Pineda ◽  
Carlos Hermenegildo ◽  
Juan J. Tarín ◽  
Paz Laporta ◽  
Antonio Cano ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Spontaneous Abortion ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Increased Risk ◽  
Estrogen Receptor Alpha Gene ◽  
Alpha Gene

scholarly journals Association Study of Estrogen Receptor Alpha Gene Polymorphisms with Spontaneous Abortion: Is This a Possible Reason for Unexplained Spontaneous Abortion?

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Negin Anousha ◽  
Arash Hossein-Nezhad ◽  
Firouzeh Biramijamal ◽  
Ali Rahmani ◽  
Zhila Maghbooli ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Spontaneous Abortion ◽  
Estrogen Receptor Alpha ◽  
Fetal Tissue ◽  
Sequencing Analysis ◽  
Nucleotide Polymorphisms ◽  
Placental Development ◽  
Receptor Alpha ◽  
Estrogen Receptor Alpha Gene ◽  
Alpha Gene

Estrogen plays a crucial role in fetal and placental development through estrogen receptors. Association of estrogen receptor alpha gene (ESR1) polymorphisms with spontaneous abortion has been shown in some studies. Our main goal was to study the potential association of spontaneous abortion with theESR1gene variations (PvuIIandXbaI) in fetal tissue. Totally, 161 samples were recruited including 80 samples of formalin-fixed paraffin-embedded fetal tissue from spontaneous abortion and 81 samples of normal term placental tissue. The restriction fragment length polymorphism (RFLP) method was performed for genotyping the rs2234693 (A/GXbaI) and rs9340799 (T/CPvuII) single nucleotide polymorphisms located in intron 1 ofESR1. The results have been confirmed by DNA sequencing analysis. The different genotypes distribution was detected in two study groups. Haplotype analysis indicated thatppxxis protective genotype against spontaneous abortion (P= 0.01). In conclusion, the potential role ofESR1genetic variation in spontaneous abortion might be valuable in high-risk subjects, and that needs to be confirmed with future studies.

scholarly journals Relationship Between Polymorphism in Exon 8 of Estrogen Receptor Alpha Gene and Osteoporosis in Saudi Women

2018 ◽  
Vol 08 (01) ◽  
Author(s):  
Lina M Al Neghery ◽  
Maha H Daghestani ◽  
Suphia M Sherbeeni ◽  
Sana A Ajaj ◽  
Mazen H Daghestani ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Saudi Women ◽  
Estrogen Receptor Alpha Gene ◽  
Alpha Gene

scholarly journals Polymorphisms in the Estrogen Receptor Alpha Gene and Mammographic Density Result Study in Brazilian Women

2013 ◽  
Vol 5 (12) ◽  
Author(s):  
Marilene Alícia Souza ◽  
Angela Maggio da Fonseca ◽  
Vicente Renato Bagnoli ◽  
Nestor de Barros ◽  
Victor Hugo Souza Hortense ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Mammographic Density ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Density Result ◽  
Estrogen Receptor Alpha Gene ◽  
Alpha Gene
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