The role of benign prostatic hyperplasia treatments in ejaculatory dysfunction

AbstractBackgroundDisturbance in cell cycle regulatory genes is a common finding among many types of cancers. The aim of this study is to evaluate the role of cyclin D1 and DJ-1 in benign prostatic hyperplasia (BPH) and prostate cancer (PC).MethodThe current study enclosed 40 patients diagnosed with PC and 40 cases of BPH. The expression level of cyclin D1 and DJ-1 were evaluated by immunohistochemistry (IHC). Cyclin D1 scored depending on the percentage of stained nuclear tumor cells. While scoring of DJ-1 was based on intensity. The results were correlated with clinicopathological features and outcome.ResultsIn the PC group, cyclin D1 was detected in 95% and overexpressed in 42.5%, DJ-1 was positively stained in 85% and overexpressed in 47.5%. Meanwhile, in the BPH group, cyclin D1 was not detected and DJ-1 stained in only 2.5%. There was a statistically significant difference in Gleason score (GS), tumor stage, size, and treatment failure (p =< 0.001). In the terms of PC diagnosis prediction, although cyclin D1 was more specific (100%), DJ-1 is more sensitive than cyclin D1 (80%, 70%, respectively) (p = 0.000).ConclusionsCyclin D1 and DJ-1 may emerge as a promising way for diagnosis of PC in certain circumstances, as the presence of insufficient tissue sampling, small foci of carcinoma or benign lesions mimic PC. This is in addition to the known role of cyclin D1 and DJ-1 in PC prognosis.

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MP19-18 THE ROLE OF MATRIX METALLOPROTEINASES AND THEIR TISSUE INHIBITORS IN THE OBSTRUCTED BLADDER SECONDARY TO BENIGN PROSTATIC HYPERPLASIA: ANALYSIS OF EXPRESSION OF 8 GENES

The Journal of Urology ◽

10.1016/j.juro.2014.02.719 ◽

2014 ◽

Vol 191 (4S) ◽

Author(s):

Yuri A. Ferreira ◽

Joao A. Barbosa ◽

Marco A. Nunes ◽

Sabrina T. Reis ◽

Nayara I. Viana ◽

...

Keyword(s):

Benign Prostatic Hyperplasia ◽

Matrix Metalloproteinases ◽

Prostatic Hyperplasia ◽

Tissue Inhibitors

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Role of PPAR-α agonist fenofibrate in the treatment of induced benign prostatic hyperplasia with dysplastic changes in rats

Fundamental and Clinical Pharmacology ◽

10.1111/fcp.12384 ◽

2018 ◽

Vol 32 (6) ◽

pp. 617-626 ◽

Cited By ~ 4

Author(s):

Marwa M.M. Refaie ◽

Rehab A. Rifaai ◽

Nagwa M. Zenhom

Keyword(s):

Benign Prostatic Hyperplasia ◽

Prostatic Hyperplasia

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Role of Prostate Ultrasonography to Predict The Efficacy of Bipolar Prostatectomy in Benign Prostatic Hyperplasia

10.21203/rs.3.rs-497241/v1 ◽

2021 ◽

Author(s):

Ali Ibrahim ◽

Diaaeldin Taha ◽

Mona Talaat ◽

Hossam Nabeeh ◽

Tarek Abdelbaky

Keyword(s):

Benign Prostatic Hyperplasia ◽

Clinical Outcomes ◽

Transurethral Resection ◽

Erectile Function ◽

Urine Volume ◽

Close Correlation ◽

Prostatic Hyperplasia ◽

Significant Difference ◽

Maximum Improvement

Abstract Background: We evaluated the role of prostatic ultrasonography to predict the clinical outcomes of Bipolar Transurethral resection of the prostate. Methods: 109 Patients complaining of lower urinary tract symptoms (LUTs) due to Benign Prostatic Hyperplasia (BPH) were evaluated preoperatively and postoperatively (at 1, 3, and 6 months) using ultrasonography (pelvi-abdominal and transrectal ), the International Prostate Symptom Score (IPSS), uroflowmetry, post-void residual urine volume (PVR), ejaculatory domain, and the erectile function domain of the International Index of Erectile Function (IIEF-ED). The safety of the procedure was assessed by Modified Clavien classification of complications.Result: There was a close correlation between residual tissue of prostate detected by ultrasonography and clinical outcomes. The prostate volume was significantly decreased postoperatively with a concomitant significant improvement of IPSS, Qmax, and PVR over six months of follow-up (P <0.001 ). 57.8 % of the cases in this study were sexually active, and there was no significant difference in the IIEF-ED score between preoperative and postoperative evaluation.Conclusion: Prostate ultrasonography has a significant predictive value as a single investigating tool to evaluate the clinical outcomes after bipolar transurethral resection of the prostate (TURP). The maximum improvement in IPSS and ultrasonographic measurements were detected at six months postoperatively.

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