Objectives- Prostate is a bromusculoglandular structure situated at the neck of urinary bladder. It enlarges due to
benign hyperplasia of prostate (BHP), prostatic intraepithelial neoplasia (PIN) or adenocarcinoma. Enlargement of
prostate is associated with raised serum level of prostate-specic antigen (PSA) and altered expression of estrogen receptor (ER) and
progesterone receptor (PR). The aim of our study is to correlate the histopathology, PSA levels and altered expression of ER and PR by
immunohistochemistry in different prostatic growth lesions.
Methodology- Patients diagnosed as having prostatic growth were enrolled and their serum PSA levels were noted. Histopathological
examination and immunohistochemical analysis of prostatic tissues for ER and PR were carried out to nd out correlation of different type of
growth with serum PSA level and expression of ER and PR.
Results- A total 96 cases studied of them 61(63.54%) patients presented with BHP, 20(20.83%) patients with BHP with chronic prostatitis, 3
patients presented with metaplastic changes, 5 cases with of PIN and 6 patients presented with adenocarcinoma with different Gleason score. PR
expression positivity in epithelial cells and stromal cells of BHP cases were 51(83.6%) and 53(86.88%) respectively. Patients presented with
adenocarcinoma showed only 33.33 %( 2cases) positivity in epithelial cells and 50% (3cases) positivity in stromal cells. Serum PSA level were
signicantly higher in adenocarcinoma patients as compare to BHP patients.
Conclusion- By observing these ndings it can be suggested that and antiprogesterone therapy may be helpful in the treatment of prostatic
adenocarcinoma.
MP45-08 INFLUENCE OF A TRYPTOPHAN-RICH DIET ON PROSTATIC GROWTH AND ANDROGEN RECEPTOR EXPRESSION
