Candida albicans MTLa2 regulates the mating response through both the a-factor and α-factor sensing pathways

2022 ◽  
pp. 103664
Author(s):  
Chao Li ◽  
Li Tao ◽  
Zhangyue Guan ◽  
Tianren Hu ◽  
Sijia Wang ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Mating Response

scholarly journals SST2, a Regulator of G-Protein Signaling for the Candida albicans Mating Response Pathway

2006 ◽  
Vol 5 (1) ◽  
pp. 192-202 ◽  
Author(s):  
Daniel Dignard ◽  
Malcolm Whiteway
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Candida Albicans ◽  
G Protein ◽  
Sequence Similarity ◽  
Transcriptional Profiling ◽  
Protein Signaling ◽  
Mating Response ◽  
Cycle Arrest ◽  
Strain Sc5314 ◽  
Regulated Gene Expression

ABSTRACT Candida albicans contains a functional mating response pathway that is similar to the well-studied system of Saccharomyces cerevisiae. We have characterized a regulator of G protein signaling (RGS) homolog in C. albicans with sequence similarity to the SST2 gene of Saccharomyces cerevisiae. Disruption of this gene, which had been designated SST2, causes an opaque MTL a/MTL a derivative of strain SC5314 to show hypersensitivity to the C. albicans α-factor. This hypersensitivity generates an enhanced cell cycle arrest detected in halo assays but reduces the overall mating efficiency of the cells. Transcriptional profiling of the pheromone-regulated gene expression in the sst2 mutant shows a pattern of gene induction similar to that observed in wild-type cells, but the responsiveness is heightened. This involvement of an RGS in the sensitivity to pheromone is consistent with the prediction that the mating response pathway in C. albicans requires the activation of a heterotrimeric G protein.

Constitutive activation of the Saccharomyces cerevislae mating response pathway by a MAP kinase kinase from Candida albicans

1995 ◽  
Vol 249 (6) ◽  
pp. 609-621 ◽  
Author(s):  
Karen L. Clark ◽  
Pascale J. F. Feldmann ◽  
Daniel Dignard ◽  
Robert Larocque ◽  
Alistair J. P. Brown ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Map Kinase ◽  
Constitutive Activation ◽  
Mating Response ◽  
Map Kinase Kinase

Enhanced IgE response to Candida albicans in postoperative invasive candidiasis

1996 ◽  
Vol 26 (4) ◽  
pp. 452-460 ◽  
Author(s):  
J. SAVOLAINEN ◽  
A. RANTALA ◽  
M. NERMES ◽  
L. LEHTONEN ◽  
M. VIANDER
Keyword(s):  
Candida Albicans ◽  
Invasive Candidiasis ◽  
Ige Response

Existence of Candida albicans and microorganisms in denture stomatitis patients

1997 ◽  
Vol 24 (10) ◽  
pp. 788-790 ◽  
Author(s):  
Y. KULAK ◽  
A. ARIKAN ◽  
E. KAZAZOGLU
Keyword(s):  
Candida Albicans ◽  
Denture Stomatitis

Einfluss des Trimesters einer Kolonisation mit Candida albicans auf das Schwangerschaftsoutcome

2018 ◽  
Author(s):  
I Holzer ◽  
A Farr ◽  
H Kiss ◽  
M Hagmann ◽  
L Petricevic
Keyword(s):  
Candida Albicans
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