Chemical constituents from Waltheria indica exert in vitro activity against Trypanosoma brucei and T. cruzi

Fitoterapia ◽  
2015 ◽  
Vol 105 ◽  
pp. 55-60 ◽  
Author(s):  
Sylvian Cretton ◽  
Lise Bréant ◽  
Lucie Pourrez ◽  
Chiara Ambuehl ◽  
Remo Perozzo ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Chemical Constituents ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals Antitrypanosomal Activities of Proteasome Inhibitors

2002 ◽  
Vol 46 (6) ◽  
pp. 2038-2040 ◽  
Author(s):  
Joseph Nkemgu-Njinkeng ◽  
Vera Rosenkranz ◽  
Michael Wink ◽  
Dietmar Steverding
Keyword(s):  
Drug Development ◽  
Trypanosoma Brucei ◽  
Proteasome Inhibitors ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Data Support ◽  
Nanomolar Range

ABSTRACT Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of proteasome inhibitors for rational antitrypanosomal drug development.

scholarly journals In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase

Molecules ◽  
2015 ◽  
Vol 20 (9) ◽  
pp. 16154-16169 ◽  
Author(s):  
Fabian Herrmann ◽  
Mairin Lenz ◽  
Joachim Jose ◽  
Marcel Kaiser ◽  
Reto Brun ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
In Silico ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
In Silico Identification ◽  
Natural Inhibitors

scholarly journals In vitro activity of salinomycin and monensin derivatives against Trypanosoma brucei

2016 ◽  
Vol 9 (1) ◽  
Author(s):  
Dietmar Steverding ◽  
Michał Antoszczak ◽  
Adam Huczyński
Keyword(s):  
Trypanosoma Brucei ◽  
Vitro Activity ◽  
In Vitro Activity

In Vitro Activity of Phytocannabinoids from High Potency Cannabis sativa

Planta Medica ◽  
2012 ◽  
Vol 78 (05) ◽  
Author(s):  
A Husni ◽  
S Ross ◽  
O Dale ◽  
C Gemelli ◽  
G Ma ◽  
...  
Keyword(s):  
Cannabis Sativa ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
High Potency
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