Calculating the exclusion probability and paternity index for X-chromosomal loci in the presence of substructure

2005 ◽  
Vol 149 (2-3) ◽  
pp. 201-203 ◽  
Author(s):  
Karen L. Ayres ◽  
William M. Powley
Keyword(s):  
Exclusion Probability ◽  
Paternity Index ◽  
Chromosomal Loci

scholarly journals Short-Time Dynamics E. Coli Chromosomal Loci Reveal a Dependence on Coordinate and Indicate the Presence of a Sporadic but Ubiquitous Super-Diffusive Motion

2014 ◽  
Vol 106 (2) ◽  
pp. 78a
Author(s):  
Avelino Javer ◽  
Zhicheng Long ◽  
Nathan J. Kuwada ◽  
Eileen Nugent ◽  
Marco Grisi ◽  
...  
Keyword(s):  
Diffusive Motion ◽  
Time Dynamics ◽  
E Coli ◽  
Short Time ◽  
Chromosomal Loci

scholarly journals Sex-biased migration and admixture in macaque species revealed by comparison between autosomal and X-chromosomal genomic sequences

2020 ◽  
Author(s):  
Naoki Osada ◽  
Kazunari Matsudaira ◽  
Yuzuru Hamada ◽  
Suchinda Malaivijitnond
Keyword(s):  
Genomic Diversity ◽  
Hybrid Origin ◽  
Mitochondrial Genomes ◽  
Whole Genome ◽  
Genome Sequences ◽  
X Chromosomes ◽  
Specific Hybridization ◽  
Predominantly Female ◽  
Chromosomal Loci

AbstractThe role of sex-specific demography in hybridization and admixture of genetically diverged species and populations is essential to understand the mechanisms forming the genomic diversity of sexually reproducing organisms. In order to infer how sex-linked genetic loci have been differentiated undergoing frequent hybridization and admixture, we examined 17 whole-genome sequences of seven species of the genus Macaca, which shows frequent inter-specific hybridization and predominantly female philopatry. We found that hybridization and admixture were prevalent within these species. For three cases of suggested hybrid origin of species/subspecies, M. arctoides, M. fascicularis ssp. aurea, and Chinese M. mulatta, we examined the level of admixture of X chromosomes, which is less affected by male-biased migration than that of autosomes. In one case, we were able to determine that M. cyclopis and M. fuscata was genetically closer to Chinese M. mulatta than to the Indian M. mulatta, and the admixture level of Chinese M. mulatta and M. fuscata/cyclopis was more pronounced on the X chromosome than on autosomes. Since the mitochondrial genomes of Chinese M. mulatta, M. cyclopis, and M. fuscata were found to cluster together, and the mitochondrial genome of Indian M. mulatta is more distantly related, the observed pattern of genetic differentiation on X-chromosomal loci is consistent with the nuclear swamping hypothesis, in which strong, continuous male-biased introgression from the ancestral Chinese M. mulatta population to a population related to M. fuscata and M. cyclopis generated incongruencies between the genealogies of the mitochondrial and autosomal genomes.

Allelic imbalance at chromosomal loci implicated in the pathogenesis of oral precancer, cumulative loss and its relationship with progression to cancer

Oral Oncology ◽  
1998 ◽  
Vol 34 (2) ◽  
pp. 77-83 ◽  
Author(s):  
M. Partridge ◽  
G. Emilion ◽  
S. Pateromichelakis ◽  
R. A'Hern ◽  
E. Phillips ◽  
...  
Keyword(s):  
Allelic Imbalance ◽  
Oral Precancer ◽  
Chromosomal Loci

scholarly journals Mutational Analysis of Metronidazole Resistance in Helicobacter pylori

2005 ◽  
Vol 49 (3) ◽  
pp. 1236-1237 ◽  
Author(s):  
Jill M. Moore ◽  
Nina R. Salama
Keyword(s):  
Helicobacter Pylori ◽  
Mutational Analysis ◽  
Transposon Mutagenesis ◽  
Human Stomach ◽  
Metronidazole Resistance ◽  
H Pylori ◽  
Chromosomal Loci

ABSTRACT Metronidazole is one of a few antibiotics effective in eliminating Helicobacter pylori infection of the human stomach. Several chromosomal loci have been implicated in resistance to this drug. Saturation transposon mutagenesis of the H. pylori genome revealed inactivation of the rdxA gene as uniquely able to confer metronidazole resistance.

Contribution of ABO-Rhesus/Electrophoresis of hemoglobin methods and Short Tandem Repeats analysis in the determination of paternity in Burkina Faso, West Africa

2020 ◽  
Author(s):  
Missa Millogo ◽  
Serge Theophile Soubeiga ◽  
Bapio Valerie Jean Telesphore Bazie ◽  
Theodora Mahoukede Zohoncon ◽  
Albert Theophane Yonli ◽  
...  
Keyword(s):  
Tandem Repeat ◽  
Short Tandem Repeat ◽  
High Performance ◽  
Short Tandem Repeats ◽  
Tandem Repeats ◽  
Repeat Analysis ◽  
Paternity Index ◽  
Genetic Analyzer ◽  
Short Tandem

Abstract Background: the establishment of filiation by the current ABO, HLA, MNS, Kells and serum tests, pose a real reliability problem. It is then necessary to combine these methods with or to use high-performance methods such as microsatellite genetic analysis or short tandem repeats. This study aimed to compare the short tandem repeat technique with ABO/Rhesus system in combination with electrophoresis of hemoglobin. Methods: Fourteen (14) contested paternity trios were investigated. Blood samples were collected to determine blood groups using the Beth-Vincent method and the type of hemoglobin by electrophoresis. Blood spots on FTA paper were used for the analysis of 16 STR loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818, FGA, Amel) by capillary electrophoresis on the ABI 31310 Genetic Analyzer. The generated sequences were analyzed with GeneMapper® software version 3.2.1. The data were analyzed to determine the paternity index and the probability of paternity. Results: Of the fourteen (14) trios studied, ten (10) cases were probable inclusion, three (03) cases were exclusion and one (01) case was an undetermined paternity outcome with the ABO-Rhesus/ electrophoresis of hemoglobin system. While the analysis of genetic polymorphisms in DNA gave five (05) inclusions versus nine (09) exclusions of paternity. Of the 10 probable inclusion cases given by the ABO-Rhesus/Electrophoresis of hemoglobin system, only 05 cases (50%) were confirmed for inclusion by Short tandem repeat analysis. Conclusion: The analysis of short tandem repeat with sixteen genetic markers is more reliable in determining paternity than ABO-Rhesus/hemoglobin electrophoresis techniques.

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