Role of Enhancement of Intracellular Reactive Oxygen Species in the Sensitivity to Apoptosis Induced by Cisplatin, Etoposide and Histone Deacetylase inhibitors in Burkittʼs Lymphoma cells

2010 ◽  
Vol 49 ◽  
pp. S59
Author(s):  
Ana Carolina dos Santos Ferreira ◽  
Renan Amphilophio Fernandes ◽  
Giselle Pinto de Faria ◽  
Flavia da Cunha Vasconcelos ◽  
Claudete Esteves Klumb ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Reactive Oxygen ◽  
Intracellular Reactive Oxygen Species ◽  
Oxygen Species ◽  
Lymphoma Cells

scholarly journals Role of p85α in neutrophil extra- and intracellular reactive oxygen species generation

Oncotarget ◽  
2016 ◽  
Vol 7 (17) ◽  
pp. 23096-23105 ◽  
Author(s):  
Xing Jun Li ◽  
Lisa Deng ◽  
Stephanie L. Brandt ◽  
Charles B. Goodwin ◽  
Peilin Ma ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Intracellular Reactive Oxygen Species ◽  
Oxygen Species

scholarly journals Generation of Reactive Oxygen Species during Apoptosis Induced by DNA-Damaging Agents and/or Histone Deacetylase Inhibitors

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Barbora Brodská ◽  
Aleš Holoubek
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Line ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Actinomycin D ◽  
Reactive Oxygen ◽  
Leukemia Cell Line ◽  
Ros Production ◽  
Oxygen Species ◽  
Dna Damaging Agents

Reactive oxygen species play an important role in the process of apoptosis in many cell types. In this paper, we analyzed the role of ROS in DNA-damaging agents (actinomycin D or decitabine), which induced apoptosis of leukemia cell line CML-T1 and normal peripheral blood lymphocytes (PBL). The possibility of synergism with histone deacetylase inhibitors butyrate or SAHA is also reported. We found that in cancer cell line, ROS production significantly contributed to apoptosis triggering, while in normal lymphocytes treated by cytostatic or cytotoxic drugs, necrosis as well as apoptosis occurred and large heterogeneity of ROS production was measured. Combined treatment with histone deacetylase inhibitor did not potentiate actinomycin D action, whereas combination of decitabine and SAHA brought synergistic ROS generation and apoptotic features in CML cell line. Appropriate decrease of cell viability indicated promising therapeutic potential of this combination in CML, but side effects on normal PBL should be taken into attention.

Fetal hemoglobin induction by histone deacetylase inhibitors involves generation of reactive oxygen species

2006 ◽  
Vol 34 (3) ◽  
pp. 264-273 ◽  
Author(s):  
Cheng-Hui Hsiao ◽  
Wei Li ◽  
Tzu-Fang Lou ◽  
B. Surendra Baliga ◽  
Betty S. Pace
Keyword(s):  
Reactive Oxygen Species ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Reactive Oxygen ◽  
Fetal Hemoglobin ◽  
Oxygen Species

scholarly journals Comprehension of the Relationship between Autophagy and Reactive Oxygen Species for Superior Cancer Therapy with Histone Deacetylase Inhibitors

Oxygen ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 22-31
Author(s):  
Yuka Ikeda ◽  
Nozomi Nagase ◽  
Ai Tsuji ◽  
Kurumi Taniguchi ◽  
Yasuko Kitagishi ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cancer Cells ◽  
Histone Deacetylase ◽  
Cell Biology ◽  
Histone Deacetylase Inhibitors ◽  
Critical Role ◽  
Reactive Oxygen ◽  
Cancer Therapeutics ◽  
Epigenetic Mechanism ◽  
Oxygen Species

Epigenetics contains various mechanisms by which cells employ to regulate the transcription of many DNAs. Histone acetylation is an obvious example of the epigenetic mechanism regulating the expression of several genes by changing chromatin accessibility. Histone deacetylases (HDACs) are a class of enzymes that play a critical role in the epigenetic regulation by deacetylation of histone proteins. Inhibitors of the histone deacetylase could result in hyperacetylation of histones, which eventually induce various cellular consequences such as generation of reactive oxygen species (ROS), activation of apoptotic pathways, and initiating autophagy. In particular, excessive levels of ROS have been proposed to contribute to the pathophysiology of various diseases including cancer. Cancers are, as it were, a class of redox diseases. Low levels of ROS are beneficial for cells, however, cancer cells generally have high levels of ROS, which makes them more susceptible than normal cells to the further increases of ROS levels. Cancer cells exhibit metabolic alterations for managing to sustain these oxidative stresses. There is a growing interest in the use of HDAC inhibitors as promising cancer therapeutics with potentiating the activity of established therapeutic applications. Therefore, it should be important to understand the underlying relationship between the regulation of HDACs, ROS production, and cancer cell biology.

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