Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency

2022 ◽  
Vol 178 ◽  
pp. 246-261
Author(s):  
Renlei Yang ◽  
Jiao Zhang ◽  
Jie Li ◽  
Ran Qin ◽  
Jie Chen ◽  
...  
Keyword(s):  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Age Related

Effect of age on renal responsiveness to parathyroid hormone and calcitonin in rats

1987 ◽  
Vol 114 (2) ◽  
pp. 173-178 ◽  
Author(s):  
H. J. Armbrecht ◽  
N. Wongsurawat ◽  
R. E. Paschal
Keyword(s):  
Parathyroid Hormone ◽  
Age Groups ◽  
Phosphate Transport ◽  
Serum Concentrations ◽  
Adult Rats ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Age Related ◽  
Old Adult

ABSTRACT The purpose of these studies was to determine whether the responsiveness of the kidney to parathyroid hormone (PTH) and calcitonin changed with age. Experiments were performed in young (3 months old), adult (12–14 months old) and old (22–24 months old) male Fischer 344 rats fed normal diets and thyroparathyroidectomized. Parathyroid hormone was administered i.p. at 24, 12 and 2 h before death and calcitonin was given i.p. at 12 and 2 h before death. Parathyroid hormone significantly increased the conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) by renal slices from young but not adult or old animals. A similar age-related decline in the capacity of PTH to raise serum 1,25-dihydroxyvitamin D (1,25-(OH)2D) levels was also seen. Parathyroid hormone significantly decreased tubular reabsorption of phosphorus, increased concentrations of urinary cyclic AMP (cAMP) and increased serum concentrations of calcium in all age groups. In contrast, calcitonin significantly increased 1,25-(OH)2D3 production by renal slices from both young and adult animals. Calcitonin decreased serum concentrations of calcium in young but not in adult rats. These results suggest that there are maturational changes in the PTH- and cAMP-dependent pathways in the kidney but not in the calcitonin- and cAMP-independent pathways. The changes in the PTH- and cAMP-dependent pathways affect the stimulation of 1,25-(OH)2D production but not the inhibition of phosphate transport. J. Endocr. (1987) 114, 173–178

Vitamin D and Calcitonin Treatment in Patients with Femoral Neck Fracture: A Prospective Controlled Clinical Study

1989 ◽  
Vol 17 (3) ◽  
pp. 226-242 ◽  
Author(s):  
E. Harju ◽  
R. Punnonen ◽  
R. Tuimala ◽  
J. Salmi ◽  
I. Paronen
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Serum Levels ◽  
Serum Calcitonin ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Age Related ◽  
Neck Fracture ◽  
25 Hydroxyvitamin D

The effects on general and bone metabolism of femoral neck fracture patients of 0.25 μg α-calcoid given orally twice daily ( n=9) and 25 μg calcitonin given subcutaneously 30 times ( n=10) in 10 weeks were studied against a control ( n=ll). Bone histology and histomorphometry showed non-age related osteoporosis in 30% and osteomalacia in 22% of the patients studied. Impaired serum vitamin D status was found in 47 – 88% of patients, secondary hyperparathyroidism and increased serum parathyroid hormone in 59% and decreased serum calcitonin levels in 69%. On histology, normal findings and non-age related osteoporosis on histology were associated with low serum levels of 25-hydroxyvitamin D3,1,25- and 24,25-dihydroxy vitamin D3. Very high serum levels of 1,25-dihydroxyvitamin D3 and low levels of 25-hydroxyvitamin D3 occurred in fracture patients with osteomalacia. Calcitonin improved calcium balance, reduced osteoporosis and increased the serum 1,25- and 24,25-dihydroxyvitamin D3 levels but had no effect on osteomalacia. Vitamin D reduced osteomalacia, slightly increased the serum 1,25-dihydroxyvitamin D3 concentration and decreased serum levels of parathyroid hormone. Both treatments gave a similar slight decrease in serum calcitonin concentrations. A mechanism of action for the treatments is suggested.

Modulation of Age-Related Changes in Serum 1,25-Dihydroxyvitamin D and Parathyroid Hormone by Dietary Restriction of Fischer 344 Rats

1988 ◽  
Vol 118 (11) ◽  
pp. 1360-1365 ◽  
Author(s):  
H. James Armbrecht ◽  
Randy Strong ◽  
Monica Boltz ◽  
David Rocco ◽  
W. Gibson Wood ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Dietary Restriction ◽  
Fischer 344 Rats ◽  
Dihydroxyvitamin D ◽  
Fischer 344 ◽  
1,25 Dihydroxyvitamin D ◽  
Age Related ◽  
Age Related Changes

scholarly journals 1,25‐Dihydroxyvitamin D protects against age‐related osteoporosis by a novel VDR‐Ezh2‐p16 signal axis

Aging Cell ◽  
2019 ◽  
Vol 19 (2) ◽  
Author(s):  
Renlei Yang ◽  
Jie Chen ◽  
Jiao Zhang ◽  
Ran Qin ◽  
Rong Wang ◽  
...  
Keyword(s):  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Age Related

Kinetics of 1,25-dihydroxyvitamin D metabolism in the aging rat

1992 ◽  
Vol 262 (6) ◽  
pp. E906-E910 ◽  
Author(s):  
L. Wada ◽  
R. Daly ◽  
D. Kern ◽  
B. Halloran
Keyword(s):  
Age Groups ◽  
Urinary Calcium ◽  
Plasma Calcium ◽  
Constant Infusion ◽  
Metabolic Clearance ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Age Related ◽  
Calcium Phosphorus ◽  
Kinetics Of

To determine whether postmaturational aging influences the kinetics of 1,25-dihydroxyvitamin D [1,25(OH)2D] metabolism in the rat, we measured the metabolic clearance (MCR) and production (PR) rates of 1,25(OH)2D in 6-, 12-, 18-, and 24-mo-old Fischer 344 rats using the constant infusion method. Plasma calcium, phosphorus, and parathyroid hormone (PTH), urinary calcium and phosphorus, and glomerular filtration rate (GFR) were also measured. MCR and PR increased 57 and 91%, respectively (when expressed per rat), and 32 and 39%, respectively (when expressed per kg body wt), between 6 and 24 mo of age, with the greatest increase occurring between 18 and 24 mo. The plasma concentration of 1,25(OH)2D remained unchanged. Plasma PTH, when compared with 6-mo-old animals, was significantly elevated at 18 mo (147%) and even higher at 24 mo (240%). GFR (51Cr-labeled EDTA clearance) remained unchanged through 18 mo but tended to be reduced at 24 mo. Plasma phosphorus tended to decrease with age, whereas plasma calcium, urinary calcium, and urinary phosphorus did not differ among the age groups. These data indicate that both clearance and production of 1,25(OH)2D increase with postmaturational aging in the rat. They also suggest that the early age-related rise in plasma PTH is neither a consequence of low plasma calcium nor of renal insufficiency.

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