scholarly journals Cell cycle dynamics and developmental dynamics of the 3D genome: toward linking the two timescales

2022 ◽  
Vol 73 ◽  
pp. 101898
Author(s):  
Hisashi Miura ◽  
Ichiro Hiratani
Keyword(s):  
Cell Cycle ◽  
3D Genome ◽  
Cell Cycle Dynamics ◽  
Developmental Dynamics

scholarly journals Author Correction: Let-7 regulates cell cycle dynamics in the developing cerebral cortex and retina

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Corinne L. A. Fairchild ◽  
Simranjeet K. Cheema ◽  
Joanna Wong ◽  
Keiko Hino ◽  
Sergi Simó ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cerebral Cortex ◽  
Cell Cycle Dynamics

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

scholarly journals CycleTrak: A novel system for the semi-automated analysis of cell cycle dynamics

2012 ◽  
Vol 365 (1) ◽  
pp. 189-195 ◽  
Author(s):  
Dennis A. Ridenour ◽  
Mary Cathleen McKinney ◽  
Caleb M. Bailey ◽  
Paul M. Kulesa
Keyword(s):  
Cell Cycle ◽  
Automated Analysis ◽  
Cell Cycle Dynamics

scholarly journals Cell cycle dynamics of NG2 cells in the postnatal and ageing brain

2009 ◽  
Vol 5 (3-4) ◽  
pp. 57-67 ◽  
Author(s):  
Konstantina Psachoulia ◽  
Francoise Jamen ◽  
Kaylene M. Young ◽  
William D. Richardson
Keyword(s):  
Cell Cycle ◽  
Corpus Callosum ◽  
Biological Significance ◽  
Growth Fraction ◽  
Cell Cycle Time ◽  
Active Population ◽  
Dorsal Telencephalon ◽  
Ng2 Cells ◽  
Cell Cycle Dynamics ◽  
Ageing Brain

Oligodendrocyte precursors (OLPs or ‘NG2 cells’) are abundant in the adult mouse brain, where they continue to proliferate and generate new myelinating oligodendrocytes. By cumulative BrdU labelling, we estimated the cell cycle timeTCand the proportion of NG2 cells that is actively cycling (the growth fraction) at ~ postnatal day 6 (P6), P60, P240 and P540. In the corpus callosum,TCincreased from <2 days at P6 to ~9 days at P60 to ~70 days at P240 and P540. In the cortex,TCincreased from ~2 days to >150 days over the same period. The growth fraction remained relatively invariant at ~50% in both cortex and corpus callosum – that is, similar numbers of mitotically active and inactive NG2 cells co-exist at all ages. Our data imply that a stable population of quiescent NG2 cells appears before the end of the first postnatal week and persists throughout life. The mitotically active population acts as a source of new oligodendrocytes during adulthood, while the biological significance of the quiescent population remains to be determined. We found that the mitotic status of adult NG2 cells is unrelated to their developmental site of origin in the ventral or dorsal telencephalon. We also report that new oligodendrocytes continue to be formed at a slow rate from NG2 cells even after P240 (8 months of age).

scholarly journals Cell cycle dynamics and complement expression distinguishes mature haematopoietic subsets arising from hemogenic endothelium

Cell Cycle ◽  
2017 ◽  
Vol 16 (19) ◽  
pp. 1835-1847 ◽  
Author(s):  
Joan P. Zape ◽  
Carlos O. Lizama ◽  
Kelly M. Cautivo ◽  
Ann C. Zovein
Keyword(s):  
Cell Cycle ◽  
Hemogenic Endothelium ◽  
Cell Cycle Dynamics

scholarly journals Imaging the fate of histone Cse4 reveals de novo replacement in S phase and subsequent stable residence at centromeres

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Jan Wisniewski ◽  
Bassam Hajj ◽  
Jiji Chen ◽  
Gaku Mizuguchi ◽  
Hua Xiao ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Elevated Temperatures ◽  
De Novo ◽  
Histone H3 ◽  
S Phase ◽  
Nuclear Accumulation ◽  
Histone H3 Variant ◽  
Functionally Impaired ◽  
Cell Cycle Dynamics ◽  
Cell Lethality

The budding yeast centromere contains Cse4, a specialized histone H3 variant. Fluorescence pulse-chase analysis of an internally tagged Cse4 reveals that it is replaced with newly synthesized molecules in S phase, remaining stably associated with centromeres thereafter. In contrast, C-terminally-tagged Cse4 is functionally impaired, showing slow cell growth, cell lethality at elevated temperatures, and extra-centromeric nuclear accumulation. Recent studies using such strains gave conflicting findings regarding the centromeric abundance and cell cycle dynamics of Cse4. Our findings indicate that internally tagged Cse4 is a better reporter of the biology of this histone variant. Furthermore, the size of centromeric Cse4 clusters was precisely mapped with a new 3D-PALM method, revealing substantial compaction during anaphase. Cse4-specific chaperone Scm3 displays steady-state, stoichiometric co-localization with Cse4 at centromeres throughout the cell cycle, while undergoing exchange with a nuclear pool. These findings suggest that a stable Cse4 nucleosome is maintained by dynamic chaperone-in-residence Scm3.

scholarly journals A quantitative FastFUCCI assay defines cell cycle dynamics at a single-cell level

2016 ◽  
Vol 130 (2) ◽  
pp. 512-520 ◽  
Author(s):  
Siang-Boon Koh ◽  
Patrice Mascalchi ◽  
Esther Rodriguez ◽  
Yao Lin ◽  
Duncan I. Jodrell ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Single Cell ◽  
Single Cell Level ◽  
Cell Level ◽  
Cell Cycle Dynamics
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