O119 A Randomized Controlled Trial of a Minimal or Maximal Ablation Strategy to Achieve Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation: Long Term Follow-Up (the Minimax Trial)

Global Heart ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e32-e33
Author(s):  
Alex J. Mclellan ◽  
Liang-Han Ling ◽  
Martin K. Stiles ◽  
Nigel A. Lever ◽  
Simon P. Fynn ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Randomized Controlled Trial ◽  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Paroxysmal Atrial Fibrillation ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Long Term Follow Up

Abstract 2752: Pulmonary Vein Isolation With And Without Additional Ablation Of Complex Fractionated Electrograms In Paroxysmal Atrial Fibrillation: Long-term Results Of A Prospective Randomized Study

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Isabel Deisenhofer ◽  
Tilko Reents ◽  
Heidi L Estner ◽  
Stephanie Fichtner ◽  
Christian von Bary ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Paroxysmal Atrial Fibrillation ◽  
Randomized Study ◽  
Intention To Treat ◽  
Long Term Follow Up ◽  
Treat Analysis

Introduction: Segmental pulmonary vein isolation (PVI) leads to elimination of paroxysmal atrial fibrillation (AF) in approximately 75% of patients. Ablation of complex fractionated atrial electrograms (CFAE) is an alternative ablation strategy. In this prospective randomized study the long-term effect of PVI alone is compared to the effect of combined PVI and CFAE ablation in paroxysmal AF. Methods: 98 patients with paroxysmal AF (57±10 years, 74 male) were randomly assigned to PVI (48 patients) or PVI+CFAE ablation (50 patients). Additional CFAE ablation was performed in the PVI+CFAE group if AF was still inducible after PVI. Follow-up results were assessed with repetitive 7 days Holter ECG and clinical evaluation including repeat ablations. Results: Additional CFAE ablation was performed in 30/50 (60%) patients of the PVI+CFAE group with still inducible AF after PVI. In each group, 2 patients were lost to long term follow-up. In the intention-to-treat analysis at 3 months and after 19±8 months, there was no significant difference between both groups (36/48 [75%] and 34/46 [74%] patients in the PVI and 37/50 [73%] and 40/48 [83%] of patients in the PVI+CFAE ablation group in sinus rhythm [p=0.32]). In subgroup analysis, patients actually treated with the combined PVI+CFAE ablation approach had a significantly better long-term success (25/28; 89%) than patients with still inducible AF who underwent PVI only (22/30;73%; p=0.02). In both groups repeat ablations were performed in 31% (PVI group; 15/48 patients) and 35% (PVI+CFAE group; 17/48 patients) (p=n.s). After 9 months, significantly more patients in the PVI+CFAE group experienced sustained regular atrial tachycardia than in the PVI group (6/44 versus 1/39 patients, P=0.02). Conclusion: The combination of PVI and CFAE ablation was equally effective than PVI alone in reaching freedom of AF in the intention-to-treat analysis. During long-term follow-up, patients actually treated with combined PVI+CFAE ablation had a significantly better outcome (89% vs. 73%). However, the rate of ablation-induced regular atrial tachycardias is inreased.

scholarly journals Long-Term Follow-Up After Cryothermic Ostial Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation

2008 ◽  
Vol 51 (8) ◽  
pp. 850-855 ◽  
Author(s):  
Wendel Moreira ◽  
Randy Manusama ◽  
Carl Timmermans ◽  
Benoit Ghaye ◽  
Suzanne Philippens ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Paroxysmal Atrial Fibrillation ◽  
Long Term Follow Up

scholarly journals Stepwise ablation approach versus pulmonary vein isolation in patients with paroxysmal atrial fibrillation: Randomized controlled trial

Heart Rhythm ◽  
2015 ◽  
Vol 12 (9) ◽  
pp. 1907-1915 ◽  
Author(s):  
Massimiliano Faustino ◽  
Carmine Pizzi ◽  
Tullio Agricola ◽  
Borejda Xhyheri ◽  
Grazia Maria Costa ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Randomized Controlled Trial ◽  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Paroxysmal Atrial Fibrillation ◽  
Controlled Trial ◽  
Randomized Controlled

Role of adenosine after antral pulmonary vein isolation of paroxysmal atrial fibrillation: A randomized controlled trial

Heart Rhythm ◽  
2016 ◽  
Vol 13 (2) ◽  
pp. 407-415 ◽  
Author(s):  
Hamid Ghanbari ◽  
Ronak Jani ◽  
Atheer Hussain-Amin ◽  
Wassim Al-Assad ◽  
Elizabeth Huether ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Randomized Controlled Trial ◽  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Paroxysmal Atrial Fibrillation ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals Long‐term follow‐up of a randomized controlled trial of a text‐message diabetes self‐management support programme, SMS4BG

2019 ◽  
Vol 37 (2) ◽  
pp. 311-318 ◽  
Author(s):  
R. Dobson ◽  
R. Whittaker ◽  
Y. Jiang ◽  
C. McNamara ◽  
M. Shepherd ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Text Message ◽  
Self Management ◽  
Management Support ◽  
Randomized Controlled ◽  
Support Programme ◽  
Long Term Follow Up
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