76: Aliskiren: A New Anti-Renin Blood Pressure Medication Appears Safe and Effective in Heart Transplant Recipients

2008 ◽  
Vol 27 (2) ◽  
pp. S86-S87 ◽  
Author(s):  
M.M. Kittleson ◽  
A.K. Ankrom ◽  
J.K. Patel ◽  
M.A. Kawano ◽  
A. Ardehali ◽  
...  
1998 ◽  
Vol 85 (6) ◽  
pp. 2270-2276 ◽  
Author(s):  
Bernard Geny ◽  
Anne Charloux ◽  
Eliane Lampert ◽  
Jean Lonsdorfer ◽  
Pascal Haberey ◽  
...  

We investigated the atrial (ANP) and brain natriuretic peptides (BNP), catecholamines, heart rate, and blood pressure responses to graded upright maximal cycling exercise of eight matched healthy subjects and cardiac-denervated heart transplant recipients (HTR). Baseline heart rate and diastolic blood pressure, together with ANP (15.2 ± 3.7 vs. 4.4 ± 0.8 pmol/l; P < 0.01) and BNP (14.3 ± 2.6 vs. 7.4 ± 0.6 pmol/l; P< 0.01), were elevated in HTR, but catecholamine levels were similar in both groups. Peak exercise O2uptake and heart rate were lower in HTR. Exercise-induced maximal ANP increase was similar in both groups (167 ± 34 vs. 216 ± 47%). Enhanced BNP increase was significant only in HTR (37 ± 8 vs. 16 ± 8%; P < 0.05). Similar norepinephrine but lower peak epinephrine levels were observed in HTR. ANP and heart rate changes from rest to 75% peak exercise were negatively correlated ( r = −0.76, P < 0.05), and BNP increase was correlated with left ventricular mass index ( r = 0.83, P < 0.01) after heart transplantation. Although ANP increase was not exaggerated, these data support the idea that the chronotropic limitation secondary to sinus node denervation might stimulate ANP release during early exercise in HTR. Furthermore, the BNP response to maximal exercise, which is related to the left ventricular mass index of HTR, is enhanced after heart transplantation.


1996 ◽  
Vol 27 (2) ◽  
pp. 375-383 ◽  
Author(s):  
Randy W. Braith ◽  
Roger M. Mills ◽  
Christopher S. Wilcox ◽  
Gary L. Davis ◽  
Charles E. Wood

2000 ◽  
Vol 140 (6) ◽  
pp. 941-944 ◽  
Author(s):  
Edoardo Casiglia ◽  
Alessandra Pizziol ◽  
Valérie Tikhonoff ◽  
Alberto Mazza ◽  
Giuseppe Di Menza ◽  
...  

2014 ◽  
Vol 46 (8) ◽  
pp. 2835-2838 ◽  
Author(s):  
G. Wasilewski ◽  
P. Przybyłowski ◽  
L. Janik ◽  
E. Nowak ◽  
J. Sadowski ◽  
...  

2014 ◽  
Vol 20 (8) ◽  
pp. 602-610 ◽  
Author(s):  
Christina L. Aquilante ◽  
Robert L. Page ◽  
Anh Vu ◽  
Nicholai Roscoe ◽  
Eugene E. Wolfel ◽  
...  

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