286: Effect of 16 Weeks of Bosentan-Based Therapy on Cardiac MRI (cMRI) Derived Ventricular Function, 6-Minute Walk Test Distance (6MWD) and Borg Dyspnea Index (BDI) in Patients with Pulmonary Arterial Hypertension (PAH): Results from the COMPASS-3 Study

2010 ◽  
Vol 29 (2) ◽  
pp. S97-S97
Author(s):  
S. Murali ◽  
S.G. Lloyd ◽  
H. Gupta ◽  
F.J. Soto ◽  
M.H. Park ◽  
...  
2019 ◽  
Vol 40 (7) ◽  
pp. 1494-1502
Author(s):  
Leman Tekin Orgun ◽  
Zeynep Öztürk ◽  
Fatma Hayvacı Canbeyli ◽  
Dilek Yapar ◽  
Kıvılcım Gücüyener ◽  
...  

2016 ◽  
Vol 1 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Carmen Corina Şuteu ◽  
Theodora Benedek ◽  
Rodica Togănel

AbstractIntroduction:Pulmonary arterial hypertension (PAH) is a complex disease with poor prognosis. Serum uric acid has been proposed as a potentially non-invasive and objective parameter for prognosis and response to therapy.Objectives:To investigate the potent relationship between serum uric acid levels and functional and echocardiographic parameters in children with PAH.Methods:Serum uric acid levels were measured in 34 children with PAH and were correlated with the functional class, 6-minute walk test, and echocardiographic parameters at baseline and at 12 months follow-up.Results:In pediatric PAH patients serum uric acid levels were higher compared with the control subjects (p = 0.001). In the high uric acid group serum uric acid levels were correlated with 6-minute walk test (p = 0.008), and with several echocardiographic parameters, such as pulmonary vascular resistance (p = 0.04), fractional area change (p = 0.05), left ventricle eccentricity index (p = 0.04), right atrial area (p = 0.03), right ventricle myocardial index (p = 0.01), and pericardial effusion (p = 0.001), markers of right ventricular overload and dysfunction.Conclusions:Serum uric acid levels are easy to collect and measure, and correlate with both functional and echocardiographic parameters that reflect right ventricular dysfunction.


2010 ◽  
Vol 9 (2) ◽  
pp. 107-111 ◽  
Author(s):  
Charles D. Burger ◽  
Tonya Zeiger

The 6-minute walk test is an easy to perform and practical test that has been used in the assessment of patients with a variety of cardiopulmonary diseases including pulmonary arterial hypertension. The correlation with maximal cardiac output renders the test an indirect measure of right ventricular function in patients with significant pulmonary arterial hypertension. The test has been employed in the majority of studies evaluating the efficacy of pulmonary arterial vasodilators. In addition, the distance walked has been demonstrated to correlate with prognosis. An understanding of the 6-minute walk test indications, logistics, limitations, and interpretation is important to the clinician utilizing this test to evaluate patients with pulmonary arterial hypertension.


2012 ◽  
Vol 59 (13) ◽  
pp. E1601
Author(s):  
Gianluigi Savarese ◽  
Stefania Paolillo ◽  
Pierluigi Costanzo ◽  
Francesca Musella ◽  
Fabio Marsico ◽  
...  

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