Clinical Impact of High Sensitive Troponin T (HsTnT) on Diagnosis of Acute Coronary Syndrome (ACS)

ObjectiveCeramides are associated with coronary plaque vulnerability. We aim to investigate the potential diagnostic value of ceramides for acute coronary syndrome (ACS) in Chinese patients with chest pain.DesignProspective observational survey.SettingShanghai, China, 2016–2017.ParticipantsA total of 2773 patients with chest pain from four hospitals in Shanghai, China, between August 2016 and October 2017.Main outcome measuresPerformance of metabolites model in detection of ACS cases including ST-elevation myocardial infarction (STEMI), non-STEMI (NSTEMI) and unstable angina.ResultsPlasma levels of 12 ceramide molecules and corresponding ratios were compared between patients diagnosed with ACS and those without. Cer(d18:1/24:1(15Z))/Cer(d18:1/24:0) ratio, Cer(d18:1/14:0) and Cer(d18:1/22:0) were independent predictors of ACS after adjustment of traditional risk factors and high-sensitivecardiac troponin T. Receiver operating characteristic curve analysis showed a significant improvement in detecting ACS in the multivariable model with ceramides compared with that without (0.865 (0.840 to 0.889) vs 0.808 (0.776 to 0.841), p<0.001).ConclusionDistinct plasma ceramides are independent diagnostic predictors of ACS among patients with chest pain. Ceramides together with high-sensitive troponin and traditional factors showed great potential in identifying ACS among patients with chest pain.

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Influence of glomerular function on values of cardiac troponin T in patients with suspected acute coronary syndrome

La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine ◽

10.23736/s1825-859x.20.00050-x ◽

2020 ◽

Vol 16 (1) ◽

Author(s):

Marco Bussetti ◽

Vincenzo Roccaforte ◽

Ruggero Buonocore ◽

Fabrizio Cappellini ◽

Giammaria Liuzzi ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Cardiac Troponin ◽

Troponin T ◽

Cardiac Troponin T ◽

Glomerular Function ◽

Coronary Syndrome

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Letter in reply to the letter to the editor of Geerts N and Schanhorst V with the title “Roche Troponin T hs-STAT meets all expert opinion analytical laboratory practice recommendations for the use of the differential diagnosis of acute coronary syndrome”

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2020-0469 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Anne Marie Dupuy ◽

Anne Sophie Bargnoux ◽

François Roubille ◽

Jean Paul Cristol

Keyword(s):

Acute Coronary Syndrome ◽

Differential Diagnosis ◽

Expert Opinion ◽

Troponin T ◽

Analytical Laboratory ◽

Laboratory Practice ◽

Coronary Syndrome ◽

Practice Recommendations ◽

Letter To The Editor

AbstractOver the period from December 3rd, 2019 to March 13th, 2020, after the urgent field safety notice reported by Roche, we performed double determinations of all troponins from the same tube in parallel and in the same run. We used the same Elecsys troponin T hs reagent (ref 08469873190), first result was obtained with the current hs-cTnT application (18 min) and the second measurement was with the STAT application (9 min). On the 11,388 results in the range from 3 to 500 ng/L, we observed 4.18% discordant results (above 18.8% RCV). Overall, we observed an overestimation of the hs-cTnT STAT assay. The Elecsys Troponin T hs STAT assay demonstrated good analytical performances on Cobas e801 analyzer. However, its use according to the ESC recommendations for the 0 h/1 h algorithm should be carefully evaluated and requires further studies with serial cTn testing.

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