Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3

Heart Rhythm ◽  
2008 ◽  
Vol 5 (10) ◽  
pp. 1444-1452 ◽  
Author(s):  
Peter Milberg ◽  
Christian Pott ◽  
Martin Fink ◽  
Gerrit Frommeyer ◽  
Toshio Matsuda ◽  
...  
2020 ◽  
Vol 30 (12) ◽  
pp. 1880-1881
Author(s):  
Mehmet Taşar ◽  
Nur Dikmen Yaman ◽  
Huseyin Dursin ◽  
Murat Şimşek ◽  
Senem Özgür

AbstractCongenital Long QT Syndrome (LQTS) is a dangerous arrhythmic disorder that can be diagnosed in children with bradycardia. It is characterised by a prolonged QT interval and torsades de pointes that may cause sudden death. Long QT syndrome is an ion channelopathy with complex molecular and physiological infrastructure. Unlike the acquired type, congenital LQTS has a genetic inheritance and it may be diagnosed by syncope, stress in activity, cardiac dysfunction, sudden death or sometimes incidentally. Permanent pacemaker implantation is required for LQTS with resistant bradycardia even in children to resolve symptoms and avoid sudden death.


2012 ◽  
Vol 51 (5) ◽  
pp. 461-464 ◽  
Author(s):  
Orie Nishimoto ◽  
Morihiro Matsuda ◽  
Kei Nakamoto ◽  
Hirohiko Nishiyama ◽  
Kazuya Kuraoka ◽  
...  

2009 ◽  
Vol 32 (6) ◽  
pp. E78-E81 ◽  
Author(s):  
Fang Quan ◽  
Gao Peng ◽  
Cheng Kangan ◽  
Hu Dayi ◽  
Li Cuilan ◽  
...  

2014 ◽  
Vol 2 (1) ◽  
pp. 44-45
Author(s):  
Ahmad Mursel Anam ◽  
Raihan Rabbani ◽  
Farzana Shumy ◽  
M Mufizul Islam Polash ◽  
M Motiul Islam ◽  
...  

We report a case of drug induced torsades de pointes, following acquired long QT syndrome. The patient got admitted for shock with acute abdomen. The initial prolonged QT-interval was missed, and a torsadogenic drug was introduced post-operatively. Patient developed torsades de pointes followed by cardiac arrest. She was managed well and discharged without complications. The clinical manifestations of long QT syndromes, syncope or cardiac arrest, result from torsades de pointes. As syncope or cardiac arrest have more common differential diagnoses, even the symptomatic long QT syndrome are commonly missed or misdiagnosed. In acquired long QT syndrome with no prior suggestive feature, it is not impossible to miss the prolonged QT-interval on the ECG tracing. We share our experience so that the clinicians, especially the junior doctors, will be more alert on checking the QT-interval even in asymptomatic patients. DOI: http://dx.doi.org/10.3329/bccj.v2i1.19970 Bangladesh Crit Care J March 2014; 2 (1): 44-45


Heart Rhythm ◽  
2004 ◽  
Vol 1 (6) ◽  
pp. 720-723 ◽  
Author(s):  
Paulus Kirchhof ◽  
Stephan Zellerhoff ◽  
Gerold Mönnig ◽  
Eric Schulze-Bahr

2003 ◽  
Vol 5 (2) ◽  
pp. 97-104 ◽  
Author(s):  
Theresa A. Beery ◽  
Macaira Dyment ◽  
Kerry Shooner ◽  
Timothy K. Knilans ◽  
D. Woodrow Benson

Long QT syndrome is an inherited disorder that results in lengthened cardiac repolarization. It can lead to sudden onset of torsades de pointes, ventricular fibrillation, and death. The authors obtained a family history, performed electrocardiograms, and drew blood for DNA extraction and genotyping from 15 family members representing 4 generations of an affected family. Seven individuals demonstrated prolonged QT intervals. The authors used polymorphic short tandem repeat markers at known LQTS loci, which indicated linkage to chromosome 11p15.5 where the potassium channel, KCNQ1, is encoded. Polymerase chain reaction was used to amplify the coding region of KCNQ1. During survey of the KCNQ1 coding region, a G-to-A transition (G502A) was identified. DNA from all clinically affected but from none of the clinically unaffected family members carried the G-to-A transition. The candidate locus approach allowed an efficient mechanism to uncover the potassium channel mutation causing LQTS in this family.


2009 ◽  
Vol 27 (8) ◽  
pp. 1016.e1-1016.e3 ◽  
Author(s):  
Jia-How Chang ◽  
Te-I Weng ◽  
Cheng-Chung Fang

2003 ◽  
Vol 91 (11) ◽  
pp. 1395-1398 ◽  
Author(s):  
Bettina F. Cuneo ◽  
Marc Ovadia ◽  
Janette F. Strasburger ◽  
Hui Zhao ◽  
Tom Petropulos ◽  
...  

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