Case report: Post-transplantation acute humoral rejection apparently due to igm donor specific antibodies and/or anti-angiotensin type 1 receptor antibodies

2015 ◽  
Vol 76 ◽  
pp. 146
Author(s):  
Bobbie Rhodes-Clark ◽  
Soumya Pandey ◽  
Terry Harville
Keyword(s):  
Case Report ◽  
Humoral Rejection ◽  
Post Transplantation ◽  
Specific Antibodies ◽  
Donor Specific Antibodies ◽  
Receptor Antibodies ◽  
Angiotensin Type

scholarly journals Pretransplant angiotensin II type 1-receptor antibodies are a risk factor for earlier detection ofde novoHLA donor-specific antibodies

2016 ◽  
Vol 31 (10) ◽  
pp. 1738-1745 ◽  
Author(s):  
Eric Cuevas ◽  
José M. Arreola-Guerra ◽  
Erick A. Hernández-Méndez ◽  
Isaac Salcedo ◽  
Natalia Castelán ◽  
...  
Keyword(s):  
Risk Factor ◽  
Angiotensin Ii ◽  
Specific Antibodies ◽  
Donor Specific Antibodies ◽  
Receptor Antibodies

P1797ACUTE RENAL GRAFT FAILURE ASSOCIATED WITH AT1 RECEPTOR ANTIBODIES : 2 CASES IN SKMC

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Nihal Bashir ◽  
Mohamed AlSeiari
Keyword(s):  
Acute Rejection ◽  
Graft Function ◽  
Hyperacute Rejection ◽  
Hla Antibodies ◽  
Antibody Mediated Rejection ◽  
Donor Specific Antibodies ◽  
Stage Renal Disease ◽  
End Stage ◽  
Receptor Antibodies

Abstract Background and Aims Some kidney transplantation recipients with negative donor specific antibodies can develop acute rejection episodes which are difficult to treat, associated with non-HLA antibodies like angiotensin 2 type 1 receptor antibodies (AT1R Ab). The mechanism of rejection by AT1R ab involves vascular injury. Our cases are unique as the first patient got mineralocorticoid deficiency like picture unexpectedly. For the second case, hyperacute rejection cause in the first allograft was not identified and but hyperacute rejection episodes involving antibodies against endothelial cells are reported in literature. Method 2 patients received renal transplantation from life related donors in out institute developed acute rejection episodes. As part of investigations, we did non -HLA antibodies testing which came positive . Results Case 1 30 years old male, with end stage renal disease on hemodialysis . The patient had a live related renal transplant with Mismatch 1-1-1 and negative DSA. Induction with Basiliximab was initiated but changed to ATG due to delayed graft function. Kidney biopsy on day 6 post operatively showed diffuse moderate to severe acute tubular injury (up to necrosis) with glomerular intracapillary fibrin microthrombi, focal minimal peritubular capillaritis and mild glomerulitis and focal weak C4d positivity, highly suspicious for active antibody mediated rejection. The patient was treated with pulse steroids, ATG total of 7.5mg/kg, 3 sessions of Plasma exchange and IVIG 2 g/kg and 2 doses of Rituximab for his hyperacute rejection. AT1R antibodies titer was 11U/ml. MICA was negative. Losartan was initiated as a maintenance therapy.

Anti–Angiotensin Type 1 Receptor Antibodies in Chronic Graft-Versus-Host Disease

2014 ◽  
Vol 98 (4) ◽  
pp. 470-474 ◽  
Author(s):  
Andrada Chiron ◽  
Jean-David Bouaziz ◽  
Maryvonnick Carmagnat ◽  
Régis Peffault de Latour ◽  
Anne Lafaurie-Bergeron ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Receptor Antibodies ◽  
Angiotensin Type
Sign in / Sign up

Export Citation Format

Share Document