Human granulocytic anaplasmosis presenting as subacute abdominal pain and hyponatremia

ABSTRACT Anaplasma phagocytophilum is an obligate intracellular bacterium that infects neutrophils and causes human granulocytic anaplasmosis. Infection induces neutrophil secretion of interleukin-8 or murine homologs and perpetuates infection by recruiting susceptible neutrophils. We hypothesized that antibody blockade of CXCR2 would decrease A. phagocytophilum tissue load by interrupting neutrophil recruitment but would not influence murine hepatic pathology. C3H-scid mice were treated with CXCR2 antiserum or control prior to or on day 14 after infection. Quantitative PCR and immunohistochemistry for A. phagocytophilum were performed and severity of liver histopathology was ranked. Control mice had more infected cells in tissues than the anti-CXCR2-treated group. The histopathological rank was not different between treated and control animals. Infected cells of control mice clustered in tissue more than in treated mice. The results support the hypothesis of bacterial propagation through chemokine induction and confirm that tissue injury is unrelated to A. phagocytophilum tissue load.

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Human Granulocytic Anaplasmosis Acquired in Scotland, 2013

Emerging Infectious Diseases ◽

10.3201/eid2006.131849 ◽

2014 ◽

Vol 20 (6) ◽

pp. 1079-1081 ◽

Cited By ~ 8

Author(s):

Peter Hagedorn ◽

Maren Imhoff ◽

Christian Fischer ◽

Cristina Domingo ◽

Matthias Niedrig

Keyword(s):

Human Granulocytic Anaplasmosis ◽

Granulocytic Anaplasmosis

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Update on Human Granulocytic Anaplasmosis

Proceedings of the Vertebrate Pest Conference ◽

10.5070/v422110093 ◽

2006 ◽

Vol 22 ◽

Author(s):

Janet Foley

Keyword(s):

Human Granulocytic Anaplasmosis ◽

Granulocytic Anaplasmosis

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A Traumatic Tick Bite: A Case Report

Clinical Practice and Cases in Emergency Medicine ◽

10.5811/cpcem.2021.3.50514 ◽

2021 ◽

Vol 2 (5) ◽

pp. 210-213

Author(s):

Daniel Finnin ◽

Christopher Hanowitz

Keyword(s):

Case Report ◽

Symptomatic Improvement ◽

Tick Bite ◽

Facial Trauma ◽

Laboratory Findings ◽

Human Granulocytic Anaplasmosis ◽

Presenting Symptoms ◽

Granulocytic Anaplasmosis ◽

Prophylactic Dose ◽

Tick Borne Disease

Introduction: Human granulocytic anaplasmosis is a tick-borne disease with an increasing incidence associated with morbidity and mortality. Uncertainty remains whether a prophylactic dose of doxycycline is effective in prevention. Case Report: We present a case of an 80-year-old female with syncope, resultant facial trauma, and fever two weeks after a tick bite for which she received prophylaxis. Workup revealed anaplasmosis, and treatment led to symptomatic improvement. Conclusion: We review the presenting symptoms, laboratory findings, and treatment of anaplasmosis, as well as give caution about the limitations in prescribing a prophylactic dose of doxycycline following a tick bite.

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