scholarly journals Plasmid-mediated doxycycline resistance in a Yersinia pestis strain isolated from a rat

2018 ◽  
Vol 51 (2) ◽  
pp. 249-254 ◽  
Author(s):  
Nicolas Cabanel ◽  
Christiane Bouchier ◽  
Minoarisoa Rajerison ◽  
Elisabeth Carniel
Keyword(s):  
Yersinia Pestis ◽  
Pestis Strain

scholarly journals Reannotation of Yersinia pestis Strain 91001 Based on Omics Data

2016 ◽  
Vol 95 (3) ◽  
pp. 562-570 ◽  
Author(s):  
Yiqing Mao ◽  
Yujun Cui ◽  
Yang Liu ◽  
Yanfeng Yan ◽  
Lei Zhou ◽  
...  
Keyword(s):  
Yersinia Pestis ◽  
Omics Data ◽  
Pestis Strain

scholarly journals Protection and Safety Evaluation of Live Constructions Derived from the Pgm− and pPCP1− Yersinia pestis Strain

Vaccines ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 95
Author(s):  
Xiuran Wang ◽  
Amit K. Singh ◽  
Wei Sun
Keyword(s):  
Iron Overload ◽  
Yersinia Pestis ◽  
Mutant Strain ◽  
Lipid A ◽  
Safety Evaluation ◽  
Significant Protection ◽  
Pestis Strain ◽  
Th2 Responses ◽  
Th1 And Th2 Responses ◽  
Th1 And Th2

Based on a live attenuated Yersinia pestis KIM10(pCD1Ap) strain (Pgm−, pPCP1−), we attempted to engineer its lipid A species to achieve improvement of immunogenicity and safety. A mutant strain designated as YPS19(pCD1Ap), mainly synthesizing the hexa-acylated lipid A, and another mutant strain designated as YPS20(pCD1Ap), synthesizing 1-dephosphalated hexa-acylated lipid A (detoxified lipid A), presented relatively low virulence in comparison to KIM10(pCD1Ap) by intramuscular (i.m.) or subcutaneous (s.c.) administration. The i.m. administration with either the KIM10(pCD1Ap) or YPS19(pCD1Ap) strain afforded significant protection against bubonic and pneumonic plague compared to the s.c. administration, while administration with completely attenuated YPS20(pCD1Ap) strain failed to afford significant protection. Antibody analysis showed that i.m. administration induced balanced Th1 and Th2 responses but s.c. administration stimulated Th2-biased responses. Safety evaluation showed that YPS19(pCD1Ap) was relatively safer than its parent KIM10(pCD1Ap) in Hfe−/− mice manifesting iron overload in tissues, which also did not impair its protection. Therefore, the immune activity of hexa-acylated lipid A can be harnessed for rationally designing bacteria-derived vaccines.

A strategy to verify the absence of the pgm locus in Yersinia pestis strain candidates for select agent exemption

2009 ◽  
Vol 77 (3) ◽  
pp. 316-319 ◽  
Author(s):  
Amy L. Jenkins ◽  
Patricia L. Worsham ◽  
Susan L. Welkos
Keyword(s):  
Yersinia Pestis ◽  
Pestis Strain

scholarly journals Pestoides F, an Atypical Yersinia pestis Strain from the Former Soviet Union

2007 ◽  
pp. 17-22 ◽  
Author(s):  
Emilio Garcia ◽  
Patrick Chain ◽  
Patricia Worsham ◽  
Scott W. Bearden ◽  
Stephanie Malfatti ◽  
...  
Keyword(s):  
Soviet Union ◽  
Yersinia Pestis ◽  
Former Soviet Union ◽  
Pestis Strain

scholarly journals Draft Genome Sequence of Yersinia pestis Strain 2501, an Isolate from the Great Gerbil Plague Focus in Xinjiang, China

2012 ◽  
Vol 194 (19) ◽  
pp. 5447-5448 ◽  
Author(s):  
S. Sun ◽  
X. Yang ◽  
Y. Yuan ◽  
X. Dai ◽  
Y. Yan ◽  
...  
Keyword(s):  
Yersinia Pestis ◽  
Genome Sequence ◽  
Draft Genome ◽  
Draft Genome Sequence ◽  
Pestis Strain ◽  
Great Gerbil

scholarly journals Complete Genome Sequence of Pigmentation-Negative Yersinia pestis Strain Cadman

2016 ◽  
Vol 4 (5) ◽  
Author(s):  
Sean Lovett ◽  
Kitty Chase ◽  
Galina Koroleva ◽  
Gustavo Palacios ◽  
David Rozak ◽  
...  
Keyword(s):  
Yersinia Pestis ◽  
Genome Sequence ◽  
Causative Agent ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Pestis Strain ◽  
Level 3 ◽  
Biosafety Level

Here, we report the genome sequence of Yersinia pestis strain Cadman, an attenuated strain lacking the pgm locus. Y. pestis is the causative agent of plague and generally must be worked with under biosafety level 3 (BSL-3) conditions. However, strains lacking the pgm locus are considered safe to work with under BSL-2 conditions.

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