Carboxymethyl cellulose is a superior polyanion to dextran sulfate in stabilizing and enhancing the solubility of amorphous drug-polyelectrolyte nanoparticle complex

2019 ◽  
Vol 139 ◽  
pp. 500-508 ◽  
Author(s):  
Bingxue Dong ◽  
Kunn Hadinoto
Keyword(s):  
Carboxymethyl Cellulose ◽  
Dextran Sulfate ◽  
Amorphous Drug ◽  
Nanoparticle Complex

scholarly journals Interaction of Fibrinogen with Dextran Sulfate

1959 ◽  
Vol 43 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Susumu Sasaki ◽  
Hajime Noguchi
Keyword(s):  
Complex Formation ◽  
Chemical Analysis ◽  
Carboxymethyl Cellulose ◽  
Dextran Sulfate ◽  
Electrostatic Force ◽  
Molecular Size ◽  
Sodium Carboxymethyl Cellulose ◽  
Soluble Complex ◽  
Binding Forces ◽  
Net Charges

Interactions of fibrinogen with dextran sulfate, dextran, and carboxymethyl cellulose were investigated by turbidity measurement, chemical analysis, and electrophoresis. Dextran sulfate and fibrinogen combined even in the physiological pH region where both of them have negative net charges, and formed a precipitate and soluble complex. Since no complex formation was observed in the case of dextran, it seems that the electrostatic force plays a part in complex formation. However, sodium carboxymethyl cellulose which carries -COO- groups did not combine with fibrinogen. Therefore, it is considered that there is a specificity for the interaction among ionized groups. Further, temperature and molecular size of dextran sulfate influenced the interaction to a large extent. It is concluded from these facts that other intermolecular binding forces should be taken into consideration in addition to the electrostatic force.

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