Enhancing the stability of amorphous drug-polyelectrolyte nanoparticle complex using a secondary small-molecule drug as the stabilizer: A case study of ibuprofen-stabilized curcumin-chitosan nanoplex

Targeted Protein Degradation (TPD) is an emerging new modality of drug discovery that offers unprecedented therapeutic benefits over traditional protein inhibition. Most importantly, TPD unlocks the untapped pool of the proteome that to date has been considered undruggable. Captor Therapeutics (Captor) is the fourth global, and first European, company that develops small molecule drug candidates based on the principles of targeted protein degradation. Captor is located in Basel, Switzerland and Wroclaw, Poland and exploits the best opportunities of the two sites – experience and non-dilutive European grants, and talent pool, respectively. Through over $38 M of funding, Captor has been active in three areas of TPD: molecular glues, bi-specific degraders and direct degraders, ObteronsTM.

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Applications of random graphs

10.1093/oso/9780198709893.003.0011 ◽

2017 ◽

Author(s):

A.C.C. Coolen ◽

A. Annibale ◽

E.S. Roberts

Keyword(s):

Social Networks ◽

Random Graphs ◽

Interaction Network ◽

Power Grids ◽

Protein Protein Interaction ◽

Topological Features ◽

First Case ◽

The Stability ◽

Protein Protein Interaction Network

This chapter reviews graph generation techniques in the context of applications. The first case study is power grids, where proposed strategies to prevent blackouts have been tested on tailored random graphs. The second case study is in social networks. Applications of random graphs to social networks are extremely wide ranging – the particular aspect looked at here is modelling the spread of disease on a social network – and how a particular construction based on projecting from a bipartite graph successfully captures some of the clustering observed in real social networks. The third case study is on null models of food webs, discussing the specific constraints relevant to this application, and the topological features which may contribute to the stability of an ecosystem. The final case study is taken from molecular biology, discussing the importance of unbiased graph sampling when considering if motifs are over-represented in a protein–protein interaction network.

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Supplier Development at LG Electronics

The Oxford Handbook of Supply Chain Management ◽

10.1093/oxfordhb/9780190066727.013.31 ◽

2020 ◽

Author(s):

Hyojin Kim ◽

Daesik Hur ◽

Tobias Schoenherr

Keyword(s):

Management Practice ◽

Digital Technologies ◽

Supply Management ◽

Future Research ◽

Supplier Development ◽

Environmentally Conscious ◽

Competitive Capabilities ◽

The Stability ◽

Buyer Firm

Supplier development has been a critical supply management practice since the 1990s. In many instances, it has even become imperative for buyer firms to support and prepare their supply bases for uncertain economic and market environments, socially and environmentally conscious customers, advances in digital technologies, and increasing competition. Yet, research that approaches supplier development with the objective to advance all these dimensions in an integrated fashion is scarce. This study fills this void by exploring how a buyer firm may address these emerging challenges in its supply base. Specifically, an in-depth case study of LG Electronics explores how the firm designs and operates multidimensional supplier development activities to foster the stability and sustainability of its supply base while enhancing its core suppliers’ competitive capabilities. This chapter illustrates how supplier development can be taken to the next level, presents implications for managerial practice, and outlines promising future research avenues.

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Holistic Drug Design for Multiparameter Optimization in Modern Small Molecule Drug Discovery

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2021.128003 ◽

2021 ◽

pp. 128003

Author(s):

Lewis D. Pennington ◽

Ingo Muegge

Keyword(s):

Drug Discovery ◽

Drug Design ◽

Small Molecule ◽

Small Molecule Drug ◽

Multiparameter Optimization

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Capturing Transformative Moments in a Participatory Values-Based Event

Journal of Transformative Education ◽

10.1177/1541344621996247 ◽

2021 ◽

pp. 154134462199624

Author(s):

Felix Okechukwu Dike ◽

JohnBosco Chika Chukwuorji

Keyword(s):

Transformative Learning ◽

Learning Outcomes ◽

Study Design ◽

Present Moment ◽

Case Study Design ◽

Fresh Perspective ◽

The Stability

The theory of transformative learning (TL) has been criticized secondhand for its lack of clarity in capturing and explaining in detail the processes undergone by learners who are going through TL experiences and their link to learning outcomes. Using a case study design, and carefully synthesized TL processes (TLPs) from Mezirow’s TL theory, we present—moment by moment—the TLPs linked to outcomes identified among a group of teachers who participated in a values-based workshop. Participants were followed through interviews for over 72 weeks to trace the stability of their TL outcome. TL processes identified were compared to Mezirow’s 10 processes. The article discusses ontological transformations gained and offers fresh perspective to identifying TLPs that can be linked to outcomes.

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Enabling rapid COVID-19 small molecule drug design through scalable deep learning of generative models

The International Journal of High Performance Computing Applications ◽

10.1177/10943420211010930 ◽

2021 ◽

pp. 109434202110109

Author(s):

Sam Ade Jacobs ◽

Tim Moon ◽

Kevin McLoughlin ◽

Derek Jones ◽

David Hysom ◽

...

Keyword(s):

Small Molecule ◽

Molecular Design ◽

Turnaround Time ◽

Generative Models ◽

Quality Model ◽

Training Time ◽

Small Molecule Drug ◽

Training Approach ◽

Previous State ◽

Multi Level

We improved the quality and reduced the time to produce machine learned models for use in small molecule antiviral design. Our globally asynchronous multi-level parallel training approach strong scales to all of Sierra with up to 97.7% efficiency. We trained a novel, character-based Wasserstein autoencoder that produces a higher quality model trained on 1.613 billion compounds in 23 minutes while the previous state of the art takes a day on 1 million compounds. Reducing training time from a day to minutes shifts the model creation bottleneck from computer job turnaround time to human innovation time. Our implementation achieves 318 PFLOPs for 17.1% of half-precision peak. We will incorporate this model into our molecular design loop enabling the generation of more diverse compounds; searching for novel, candidate antiviral drugs improves and reduces the time to synthesize compounds to be tested in the lab.

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The effect of flexural–torsional buckling on the stability of timber members: a case study

SN Applied Sciences ◽

10.1007/s42452-021-04604-6 ◽

2021 ◽

Vol 3 (6) ◽

Author(s):

Osama A. B. Hassan

Keyword(s):

Axial Compression ◽

Bending Moment ◽

List Type ◽

Torsional Buckling ◽

Solution Methods ◽

Simplified Solution ◽

The Stability ◽

Flexural Torsional Buckling ◽

Building Engineering

Abstract This study investigates the stability of timber members subjected to simultaneously acting axial compression and bending moment, with possible risk for torsional and flexural–torsional buckling. This situation can occur in laterally supported members where one side of the member is braced but the other side is unbraced. In this case, the free side will buckle out of plane while the braced side will be prevented from torsional and flexural–torsional buckling. This problem can be evident for long members in timber-frame structures, which are subjected to high axial compression combined with bending moments in which the member is not sufficiently braced at both sides. This study is based on the design requirement stated in Eurocode 5. Solution methods discussed in this paper can be of interest within the framework of structural and building Engineering practices and education in which the stability of structural elements is investigated. Article Highlights This case study investigates some design situations where the timber member is not sufficiently braced. In this case, a stability problem associated with combined torsional buckling and flexural buckling can arise. The study shows that the torsional and/or flexural–torsional buckling of timber members can be important to control in order to fulfil the criteria of the stability of the member according to Eurocode 5 and help the structural engineer to achieve safer designs. The study investigates also a simplified solution to check the effect of flexural torsional buckling of laterally braced timber members.

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