Left anterior descending coronary artery fistula to left ventricle: The revenge of a well treated myocardial infarction in the era of primary percutaneous angioplasty

2015 ◽  
Vol 187 ◽  
pp. 508-510 ◽  
Author(s):  
Umberto Barbero ◽  
Federico Ferraris ◽  
Serena Bergerone ◽  
Antonio Montefusco ◽  
Ilaria Meynet ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Left Ventricle ◽  
Coronary Artery Fistula ◽  
Percutaneous Angioplasty

A Case of Acquired Coronary Artery Fistula to the Left Ventricle after Acute Myocardial Infarction

2000 ◽  
Vol 30 (2) ◽  
pp. 221
Author(s):  
Seung Youn Kim ◽  
Hyun Sin Park ◽  
Sang Jun Park ◽  
Kyung Woo Park ◽  
Jeong Kee Seo ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Left Ventricle ◽  
Coronary Artery Fistula

Coronary artery fistula to the left ventricle

1987 ◽  
Vol 23 (3) ◽  
pp. 420
Author(s):  
B H Lee ◽  
S J Yu ◽  
E S Moon ◽  
S H Kim ◽  
Y H Choi
Keyword(s):  
Coronary Artery ◽  
Left Ventricle ◽  
Coronary Artery Fistula

Abstract 12: EMMPRIN-Targeted Magnetic Nanoparticles for in vivo Visualization and Regression of Acute Myocardial Infarction in a Model of Acute Coronary Artery Occlusion

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Irene Cuadrado ◽  
Maria Jose Garcia Miguel ◽  
Irene Herruzo ◽  
Mari Carmen Turpin ◽  
Ana Martin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Extracellular Matrix ◽  
Coronary Artery ◽  
Left Ventricle ◽  
Infarct Size ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Gadolinium Enhancement

Extracellular matrix metalloproteinase inducer EMMPRIN, is highly expressed in patients with acute myocardial infarction (AMI), and induces activation of several matrix metalloproteinases (MMPs), including MMP-9 and MMP-13. To prevent Extracellular matrix degradation and cardiac cell death we targeted EMMPRIN with paramagnetic/fluorescent micellar nanoparticles with an EMMPRIN binding peptide AP9 conjugated (NAP9), or an AP9 scramble peptide as a negative control (NAPSC). NAP9 binds to endogenous EMMPRIN as detected by confocal microscopy of cardiac myocytes and macrophages incubated with NAP and NAPSC in vitro, and in vivo in mouse hearts subjected to left anterior descending coronary artery occlusion (IV injection 50mγ/Kg NAP9 or NAP9SC). Administration of NAP9 at the same time or 1 hour after AMI reduced infarct size over a 20% respect to untreated and NAPSC injected mice, recovered left ventricle ejection fraction (LVEF) similar to healthy controls, and reduced EMMPRIN downstream MMP9 expression. In magnetic resonance scans of mouse hearts 2 days after AMI and injected with NAP9, we detected a significant gadolinium enhancement in the left ventricle respect to non-injected mice and to mice injected with NAPSC. Late gadolinium enhancement assays exhibited NAP9-mediated left ventricle signal enhancement as early as 30 minutes after nanoprobe injection, in which a close correlation between the MRI signal enhancement and left ventricle infarct size was detected. Taken together, these results point EMMPRIN targeted nanoprobes as a new tool for the treatment of AMI.

A Case of Acute Inferior Wall Myocardial Infarction and Coronary Artery Fistula Secondary to Blunt Chest Trauma

1997 ◽  
Vol 27 (1) ◽  
pp. 107
Author(s):  
Sung Woo Park ◽  
Bong Min Ko ◽  
Kwang Hee Lee ◽  
Chul Hyun Kim ◽  
Tae Myoung Choi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Blunt Chest Trauma ◽  
Chest Trauma ◽  
Coronary Artery Fistula ◽  
Inferior Wall

Abstract 2419: Left Ventricle Function Preservation by a Novel Synthetic Hydrogel Injection in Myocardial Infarction Rabbit

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Xiaoyan Li ◽  
Xuejun Jliang ◽  
Tao Wang ◽  
Taol Lin ◽  
Congxin Huang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Coronary Artery ◽  
Left Ventricle ◽  
Ethylene Glycol ◽  
Control Group ◽  
Coronary Artery Ligation ◽  
Poly Ethylene Glycol ◽  
Infarcted Myocardium ◽  
Poly Ethylene

Myocardial infarction and the subsequent heart failure remain among the world’s prominent health challenges. Other studies have demonstrated that bio-derived materials improve cardiac function after implantation for angiogenic potential. In this study, we hypothesized that injection of biomaterials into infarcted myocardium can preserve left ventricle (LV) function through its prevention of paradoxical systolic bulging. Infarction was induced in rabbit myocardium by coronary artery ligation. In sham-operated rabbits (n = 5), a suture was tied loosely around the left anterior descending coronary artery without ligating it. 7 dayslater, 100μl α-cyclodextrin (CD) solution and 100μl poly (ethylene glycol)-b-polycaprolactone-(dodecanedioic acid)-polycaprolactone-poly (ethylene glycol)(MPEG-PCL-MPEG) solution (n = 7) was injected simultaneously through Duploject applicator into the infarcted myocardium. Solid hydrogel matrix formed by linear MPEG-PCL-MPEG polymer threading into the cavities of the α-cyclodextrin after mixing. Injection of phosphate buffered saline (PBS) served as controls (n = 7). 28 days after the treatments, histological analysis indicated that injection of hydrogel prevented scar expansion and wall thinning compared with group ( P < 0.05) without more microvessel density in infarcted myocardium ( P = 0.70).By echocardiography, LV ejection fraction was significantly greater in the hydrogel group (56.09 ± 8.42%) than the control group (37.26 ± 6.36%, P = 0.001). The LV end-diastolic and end-systolic diameters were 2.07 ± 0.33 cm and 1.74 ± 0.30cm in the control group, respectively. Smaller LV end-diastolic diameter (1.61 ± 0.26cm, P = 0.005) and smaller end-systolic diameter (1.17 ± 0.23cm, P = 0.001) were found in the hydrogel group. These results suggest that α-CD/MPEG-PCL-MPEG hydrogel injection could serve structural and mechanical support of an injured LV replacing some of the functions of the damaged ECM and thus prevented paradoxical motion serves, which may eventually lead to LV remodeling and dilation prevention. Our study should initiate further experimental and clinical studies exploring potential approaches to the treatment of postinfarction heart failure.

Myocardial infarction in closed-chest dogs: a simplified method for production

1975 ◽  
Vol 39 (5) ◽  
pp. 831-833 ◽  
Author(s):  
H. A. Lappin ◽  
E. H. Botvinick ◽  
W. W. Parmley ◽  
J. V. Tyberg
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Left Ventricle ◽  
Left Coronary Artery ◽  
Sodium Pentobarbital ◽  
Simple Method ◽  
Closed Chest ◽  
Simplified Method ◽  
Coaxial Catheter

Due to our need, we sought a simple method to reliably create myocardial infarction in the closed-chest dog. Previous techniques were dangerous, time consuming, unreliable, and costly. Here we described a new coaxial catheter method by which occluded catheter plugs are embolized selectively to branches of the left coronary artery in closed chest dogs anesthetized with sodium pentobarbital (10 mg/lb). Infarcts varying in size from 3 to 27 g, 2–27% of the left ventricle, were reliably created in dogs weighing 26–70 lb. Complications were rare with only a single fatality in the last 15 procedures. The method proved safe, simple, quick, versatile, reproducible, and inexpensive.

An aneurysmal right coronary artery fistula draining into the left ventricle

2017 ◽  
Vol 27 (6) ◽  
pp. 1214-1215
Author(s):  
Dongxu Li ◽  
Yabo Wang ◽  
Qi An
Keyword(s):  
Coronary Artery ◽  
Left Ventricle ◽  
Right Coronary Artery ◽  
Rare Case ◽  
Median Sternotomy ◽  
Coronary Artery Fistula ◽  
Ct Images ◽  
Coronary Ct

AbstractWe describe a rare case of aneurysmal right coronary artery drainage into left ventricle in a 38-year old male with entailed coronary CT images. After median sternotomy surgery, the patient recovered well.

scholarly journals Multiple Small Coronary Artery Fistulas Emptying into the Left Ventricle: A Rare but Challenging Problem

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Omar Kahaly ◽  
Konstantinos Dean Boudoulas
Keyword(s):  
Coronary Artery ◽  
Left Ventricle ◽  
Coronary Artery Fistula ◽  
Coronary Arteriography ◽  
Great Vessel ◽  
Challenging Problem ◽  
Atypical Chest Pain ◽  
Coronary Artery Fistulas ◽  
Appropriate Therapy ◽  
The Right

A coronary artery fistula (CAF) is an abnormal communication between a coronary artery and a cardiac chamber or a great vessel. CAFs are rare based on coronary arteriography and when found they most often empty into the right ventricle and atrium and less often into the high pressure, low compliance left ventricle (LV). A patient who presented with atypical chest pain and was found to have multiple small CAFs originating from the ramus intermedius coronary artery and emptying into the LV is presented. This case highlights the challenges in providing an appropriate therapy for multiple small CAFs emptying into the LV.

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