scholarly journals Endostatin and osteopontin are elevated in patients with both coronary artery disease and aortic valve calcification

2015 ◽  
Vol 9 ◽  
pp. 5-9 ◽  
Author(s):  
Michael Sponder ◽  
Monika Fritzer-Szekeres ◽  
Brigitte Litschauer ◽  
Thomas Binder ◽  
Jeanette Strametz-Juranek
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Aortic Valve ◽  
Aortic Valve Calcification ◽  
Valve Calcification ◽  
Artery Disease

Nonobstructive aortic valve calcification: a window to significant coronary artery disease

2002 ◽  
Vol 161 (1) ◽  
pp. 193-197 ◽  
Author(s):  
Yehuda Adler ◽  
Mordehay Vaturi ◽  
Itzhak Herz ◽  
Zaza Iakobishvili ◽  
Jacob Toaf ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Aortic Valve ◽  
Significant Coronary Artery Disease ◽  
Aortic Valve Calcification ◽  
Valve Calcification ◽  
Artery Disease

scholarly journals Predominance of Abdominal Visceral Adipose Tissue Reflects the Presence of Aortic Valve Calcification

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Masayoshi Oikawa ◽  
Takashi Owada ◽  
Hiroyuki Yamauchi ◽  
Tomofumi Misaka ◽  
Hirofumi Machii ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Aortic Valve ◽  
Visceral Adipose Tissue ◽  
Aortic Valve Calcification ◽  
Valve Calcification ◽  
Net Reclassification Improvement ◽  
Artery Disease ◽  
Visceral Adipose

Background. Aortic valve calcification (AVC) is a common feature of aging and is related to coronary artery disease. Although abdominal visceral adipose tissue (VAT) plays fundamental roles in coronary artery disease, the relationship between abdominal VAT and AVC is not fully understood.Methods. We investigated 259 patients who underwent cardiac and abdominal computed tomography (CT). AVC was defined as calcified lesion on the aortic valve by CT. %abdominal VAT was calculated as abdominal VAT area/total adipose tissue area.Results. AVC was detected in 75 patients, and these patients showed higher %abdominal VAT (44% versus 38%,p<0.05) compared to those without AVC. When the cutoff value of %abdominal VAT was set at 40.9%, the area under the curve to diagnose AVC was 0.626. Multivariable logistic regression analysis showed that age (OR 1.120, 95% CI 1.078–1.168,p<0.01), diabetes (OR 2.587, 95% CI 1.323–5.130,p<0.01), and %abdominal VAT (OR 1.032, 95% CI 1.003–1.065,p<0.05) were independent risk factors for AVC. The net reclassification improvement value for detecting AVC was increased when %abdominal VAT was added to the model: 0.5093 (95% CI 0.2489–0.7697,p<0.01).Conclusion. We determined that predominance of VAT is associated with AVC.

Aortic Valve Calcification: Its Significance and Limitation as a Marker for Coronary Artery Disease

Angiology ◽  
2002 ◽  
Vol 53 (2) ◽  
pp. 165-169 ◽  
Author(s):  
Ismet Hisar ◽  
Mehmet Ileri ◽  
Ertan Yetkin ◽  
Izzet Tandoğan ◽  
Sengül Cehreli ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Aortic Valve ◽  
Aortic Valve Calcification ◽  
Valve Calcification ◽  
Artery Disease

Correlation between Peri-Coronary Epicardial Adipose Tissue Volume, Cardiac Calcification and the Severity of Coronary Artery Disease by Multi Slice Computed Tomography

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
A El Etriby ◽  
A El sherbiny ◽  
R Remone ◽  
A Mamdouh
Keyword(s):  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Mitral Valve ◽  
Epicardial Adipose Tissue ◽  
Calcium Score ◽  
Aortic Valve Calcification ◽  
Valve Calcification ◽  
Significant Difference ◽  
Artery Disease

ABSTRACT The authors in that article addressed a very important and relevant issue. Background Epicardial adipose tissue (EAT) is a complex endocrine organ that plays an important role in the development of unfavorable metabolic and cardiovascular risk profile. EAT may express a variety of inflammatory mediators which may contribute to the pathogenesis of coronary artery disease (CAD). Aortic and mitral valve calcification may reflect generalized atherosclerosis in the elderly and may be a marker of high prevalence and severity of CAD. There is a direct correlation (extent, severity and the future CV events) between the coronary artery calcium and the CAD. Aim and Objectives To correlate peri-coronary epicardial adipose tissue and coronary artery calcification and valvular (aortic and mitral) calcification with the severity of the coronary artery disease. Patients and Methods The study recruited 200 patients with suspected coronary artery disease. The amount of EAT surrounding the left main and the three main coronary arteries was quantified in axial cuts with the most distinct layer of EAT. The amount of calcium in the aortic and mitral valve and the coronaries were quantified with multi-detector computed tomography MDCT using dedicated software for measuring calcium score that is based on Agatson score. Coronary artery disease severity was assessed in terms of number of vessels affected and the severity of coronary stenosis by multi-planner reformation technique. Results Based on the finding of the MDCT and according to the presence of calcification in the aortic or the mitral valves, and the significance of the coronary artery disease, patients were classified into two groups, group (I): 115 patients with normal coronaries or with non significant lesions in their coronaries, and group (II): 85 patients with significant coronary artery disease. The Mean ± SD (in millimeters) of EAT for the entire study cohort in various coronary artery locations were as follows: LM EAT 9.82 ± 2.67, proximal LAD EAT 10.06 ± 2.80, mid LAD EAT 9.15 ± 2.41, distal LAD EAT 6.46 ± 1.87, proximal LCX EAT 8.10 ± 1.90, distal LCX EAT 6.83 ± 1.79, proximal RCA EAT 10.23 ± 2.42, mid RCA EAT 9.26 ± 2.72, distal RCA EAT 7.25 ± 2.58. Statistically highly significant difference was observed between the two groups with regards to LM EAT, proximal, mid and distal LAD EAT, proximal and distal LCX EAT, proximal, mid and distal RCA EAT (8.38 ± 2.18 Vs 11.77 ± 1.94 P: 0.000, 8.49 ± 2.21 Vs 12.18 ± 2.00, 7.93 ± 1.77 Vs 10.81 ± 2.16, 5.45 ± 1.26 Vs 7.82 ± 1.68 P: 0.000, 7.08 ± 1.34 Vs 9.46 ± 1.67, 6.05 ± 1.50 Vs 7.89 ± 1.61 P: 0.000, 9.01 ± 1.94 Vs 11.88 ± 1.99, 8.07 ± 2.32 Vs 10.86 ± 2.39, 6.31 ± 2.26 Vs 8.51 ± 2.45 P: 0.000; respectively). Statistically highly significant difference was observed between the two groups with regards calcium score and the severity of CAD in the three major vessels (LAD, LCX and RCA) and the total calcium score in all vessels (35 (16 – 85.5) Vs 179.5 (59.5 – 243) P: 0.000, 20.5 (7 – 50.5) Vs 56 (33 – 95) P: 0.000, 31 (9 – 54) Vs 97 (54 – 199) P: 0.000, 12 (0 – 84) Vs 286 (106 – 511) P:0.000; respectively) while calcium score in the LM was not statistically significant with the severity of CAD (4 (3 – 26) Vs 12 (9 – 16) P: 0.360). As regards aortic valve calcification there was statistically highly significant difference between the two groups; P value 0.000, while mitral valve calcification was found to be not statistically significant between the two groups P: 0.272. Conclusion The present study demonstrated a significant correlation between the peri-coronary epicardial adipose tissue, coronary calcification and aortic valve calcification and the severity of the coronary artery disease.

Abstract 15016: Calcifications of Aortic Valve, Coronary Arteries and Aorta in 500 Consecutive Patients

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Anna Galas ◽  
Ilona Michalowska ◽  
Cezary Kepka ◽  
Elzbieta Abramczuk ◽  
Ewa Orlowska-Baranowska ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery ◽  
Aortic Valve ◽  
Coronary Arteries ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Aortic Valve Calcification ◽  
Valve Calcification ◽  
Artery Disease ◽  
Diagnostic Modalities

Introduction: Diseases presenting with cardiac and vascular calcification are well known and a variety of diagnostic modalities enable detection of calcifications. However, the relationship between calcification of arteries and the aortic valve together with corresponding pathophysiological processes have not been yet unequivocally elucidated. Purposes of the study: An assessment of correlation between presence and severity of calcifications in the aortic valve, coronary arteries, aorta and influence of cardiovascular disease risk factors on prevalence of calcifications in this locations. Material and Methods: The study included consecutive patients over 60 years of age referred for computed tomography imaging of coronary artery disease. A total number of included patients reached 500 subjects. Besides coronary artery calcification (CAC), we evaluated aortic valve calcification (AVC) and ascending aorta calcification (AAC). Computed tomography examinations were performed with a dual-source, 64-slice scanner. Exclusion criteria encompassed: diagnosed aortic valve disease, history of coronary artery angioplasty, bypass grafting or heart valve surgery. Results: AVC was diagnosed in 163 patients (32.6%). Prevalence of CAC and AAC was higher than AVC and amounted to 78.8% and 59.8%, respectively. Aortic valve calcification was more often observed in men than women. Degree of AVC severity was significantly lesser than that of CAC and AAC (p=0.0001, p=0.0001). In our study population, we did not find a significant dependence between presence and severity of AVC and CAC or AAC. However, we did observe a statistically significant relationship between presence and severity of CAC and AAC. In contrast to coronary arteries and the aorta, we did not find significantly increased prevalence of AVC among patients with arterial hypertension, dyslipidemias, diabetes, smokers or patients with elevated BMI. Only sex and age exerted significant influence on development of AVC. Conclusions: Despite some similarities between the process of aortic valve calcification and that involving coronary arteries and aorta, these phenomena are not interrelated. It seems that process of calcification of the aortic valve is significantly different from atherosclerosis.

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