[P238]: Loss of heparan sulphate‐6‐sulphotransferase 1 results in retinal ganglion cell axon guidance errors at the optic chiasm and dorsal thalamus of the developing mouse visual system

2006 ◽  
Vol 24 (8) ◽  
pp. 597-598
Author(s):  
C. Conway ◽  
T. Pratt ◽  
D. Price ◽  
J. Mason
Keyword(s):  
Visual System ◽  
Ganglion Cell ◽  
Axon Guidance ◽  
Retinal Ganglion Cell ◽  
Heparan Sulphate ◽  
Optic Chiasm ◽  
Retinal Ganglion ◽  
Dorsal Thalamus ◽  
Cell Axon ◽  
Ganglion Cell Axon

scholarly journals Retinal Ganglion Cell Axon Guidance in the Mouse Optic Chiasm: Expression and Function of Robos and Slits

2000 ◽  
Vol 20 (13) ◽  
pp. 4975-4982 ◽  
Author(s):  
Lynda Erskine ◽  
Scott E. Williams ◽  
Katja Brose ◽  
Thomas Kidd ◽  
Rivka A. Rachel ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Axon Guidance ◽  
Retinal Ganglion Cell ◽  
Optic Chiasm ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Axon ◽  
Cell Axon ◽  
And Function ◽  
Ganglion Cell Axon

scholarly journals NF-Protocadherin Regulates Retinal Ganglion Cell Axon Behaviour in the Developing Visual System

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0141290 ◽  
Author(s):  
Louis C. Leung ◽  
William A. Harris ◽  
Christine E. Holt ◽  
Michael Piper
Keyword(s):  
Visual System ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Axon ◽  
Cell Axon ◽  
Ganglion Cell Axon

scholarly journals EGCG stabilizes growth cone filopodia and impairs retinal ganglion cell axon guidance

2016 ◽  
Vol 245 (6) ◽  
pp. 667-677 ◽  
Author(s):  
Karen Atkinson-Leadbeater ◽  
Carrie L. Hehr ◽  
Jill Johnston ◽  
Gabriel Bertolesi ◽  
Sarah McFarlane
Keyword(s):  
Ganglion Cell ◽  
Axon Guidance ◽  
Retinal Ganglion Cell ◽  
Growth Cone ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Axon ◽  
Cell Axon ◽  
Ganglion Cell Axon

scholarly journals Retinal Ganglion Cell Axon Sorting at the Optic Chiasm Requires Dystroglycan

2018 ◽  
Author(s):  
Reena Clements ◽  
Kevin M. Wright
Keyword(s):  
Extracellular Matrix ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Choice Point ◽  
Optic Chiasm ◽  
Basement Membranes ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Axon ◽  
Cell Axon ◽  
Ganglion Cell Axon

AbstractIn the developing visual system, retinal ganglion cell (RGC) axons project from the retina to several distal retinorecipient regions in the brain. Several molecules have been implicated in guiding RGC axons in vivo, but the role of extracellular matrix molecules in this process remains poorly understood. Dystroglycan is a laminin-binding transmembrane protein important for formation and maintenance of the extracellular matrix and basement membranes and has previously been implicated in axon guidance in the developing spinal cord. Using two genetic models of functional dystroglycan loss, we show that dystroglycan is necessary for correct sorting of contralateral and ipsilateral RGC axons at the optic chiasm. Missorted axons still target retinorecipient brain regions and persist in adult mice, even after axon pruning is complete. Our results highlight the importance of the extracellular matrix for axon sorting at an intermediate choice point in the developing visual circuit.Summary StatementAbnormal retinal ganglion cell axon sorting in the optic chiasm in the absence of functional dystroglycan results in profound defects in retinorecipient innervation.

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