scholarly journals Randomized Retinal Ganglion Cell Axon Routing at the Optic Chiasm of GAP-43-Deficient Mice: Association with Midline Recrossing and Lack of Normal Ipsilateral Axon Turning

1998 ◽  
Vol 18 (24) ◽  
pp. 10502-10513 ◽  
Author(s):  
David W. Sretavan ◽  
Kelly Kruger
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Optic Chiasm ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Axon ◽  
Cell Axon ◽  
Deficient Mice ◽  
Ganglion Cell Axon

scholarly journals Retinal Ganglion Cell Axon Guidance in the Mouse Optic Chiasm: Expression and Function of Robos and Slits

2000 ◽  
Vol 20 (13) ◽  
pp. 4975-4982 ◽  
Author(s):  
Lynda Erskine ◽  
Scott E. Williams ◽  
Katja Brose ◽  
Thomas Kidd ◽  
Rivka A. Rachel ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Axon Guidance ◽  
Retinal Ganglion Cell ◽  
Optic Chiasm ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Axon ◽  
Cell Axon ◽  
And Function ◽  
Ganglion Cell Axon

scholarly journals Retinal Ganglion Cell Axon Sorting at the Optic Chiasm Requires Dystroglycan

2018 ◽  
Author(s):  
Reena Clements ◽  
Kevin M. Wright
Keyword(s):  
Extracellular Matrix ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Choice Point ◽  
Optic Chiasm ◽  
Basement Membranes ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Axon ◽  
Cell Axon ◽  
Ganglion Cell Axon

AbstractIn the developing visual system, retinal ganglion cell (RGC) axons project from the retina to several distal retinorecipient regions in the brain. Several molecules have been implicated in guiding RGC axons in vivo, but the role of extracellular matrix molecules in this process remains poorly understood. Dystroglycan is a laminin-binding transmembrane protein important for formation and maintenance of the extracellular matrix and basement membranes and has previously been implicated in axon guidance in the developing spinal cord. Using two genetic models of functional dystroglycan loss, we show that dystroglycan is necessary for correct sorting of contralateral and ipsilateral RGC axons at the optic chiasm. Missorted axons still target retinorecipient brain regions and persist in adult mice, even after axon pruning is complete. Our results highlight the importance of the extracellular matrix for axon sorting at an intermediate choice point in the developing visual circuit.Summary StatementAbnormal retinal ganglion cell axon sorting in the optic chiasm in the absence of functional dystroglycan results in profound defects in retinorecipient innervation.

scholarly journals EphA3 Expressed in the Chicken Tectum Stimulates Nasal Retinal Ganglion Cell Axon Growth and Is Required for Retinotectal Topographic Map Formation

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e38566 ◽  
Author(s):  
Ana Laura Ortalli ◽  
Luciano Fiore ◽  
Jennifer Di Napoli ◽  
Melina Rapacioli ◽  
Marcelo Salierno ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Axon Growth ◽  
Retinal Ganglion ◽  
Topographic Map ◽  
Retinal Ganglion Cell Axon ◽  
Cell Axon ◽  
Ganglion Cell Axon
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