The clinical characters of acute flaccid paralysis associated with enterovirus 71 infected hand-foot-mouth disease

Background: The hand-foot-mouth disease (HFMD) is an acute communicable disease, mostly affecting children under 5 years of age and caused by human enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16). The usual incubation period is 3 to 7 days. Early symptoms are likely to be fever often followed by a sore throat followed by loss of appetite and general malaise. Aim and objectives was to study the trend of hand foot and mouth disease in a private hospital in Uttarakhand over 5 successive years.Methods: This cross-sectional study was carried among 297 cases of HFMD newborn screened at pediatrics department of Sahota Super-specialty hospital, Kashipur, Uttarakhand during year 2015 to 2019 after ethical clearance of institutional ethical committee. Diagnosis is coded with ICD-10. SPSS version 20 was used to calculate frequencies and percentiles.Results: Almost 29 cases of HMFD were picked in 2015, 32 cases in 2016, 43 cases in 2017, 81 cases in 2018, 112 in 2019. Fever observed in 86% cases. Neurological complications were observed in 9 (3%) cases, pneumonitis in 14 (4.7%) cases, cardiomyopathy observed in 3 (<1%) case. One death was reported.Conclusions: It is vital to screen patients with HFMD for these abnormal clinical presentations, allowing timely initiation of appropriate interventions to reduce the mortality. Increased awareness about vaccination in a developing nation like India and vaccination program at the grass root levels have eradicated certain lethal diseases.

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Pathogenesis of hand-foot-mouth disease caused by enterovirus 71

World Chinese Journal of Digestology ◽

10.11569/wcjd.v27.i24.1465 ◽

2019 ◽

Vol 27 (24) ◽

pp. 1465-1472

Author(s):

Chun-Rong Wang

Keyword(s):

Enterovirus 71 ◽

Mouth Disease ◽

Hand Foot Mouth Disease

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A Case of Hand-Foot-Mouth Disease observed during Routine Dental Checkup in an Immunocompetent Healthy Adult Patient

Journal of Health Sciences & Research ◽

10.5005/jp-journals-10042-1047 ◽

2017 ◽

Vol 8 (1) ◽

pp. 42-45

Author(s):

Poorna Devadoss, ◽

Skanda Ramesh, ◽

Pradeep Christopher, ◽

Anbu Velusamy

Keyword(s):

Adult Patient ◽

Hard Palate ◽

Healthy Adult ◽

Enterovirus 71 ◽

Mouth Disease ◽

Coxsackie Virus ◽

Oral Lesions ◽

Immunocompetent Adult ◽

Patient Reported ◽

Hand Foot Mouth Disease

ABSTRACT Signs of oral lesions are one of the initial indications for many major diseases. As we come across different lesions during routine dental checkups, we should be aware about the diseases associated with those lesions. A 47-year-old immunocompetent adult patient reported with small erythematous lesions in the hard palate and small ulcers in the tonsillar pillars and right buccal mucosa with mild pyrexia of 37.8°C. Maculopapular lesions were found on the palms and soles. He was diagnosed with hand-foot-mouth disease, which is caused by the following viruses: Enterovirus-71, Coxsackie Virus (CV)-16, CV-A6, and CV-A10. The severity of this condition leads to meningitis, paralytic polio, and onychomadesis (falling of nails). How to cite this article Devadoss P, Ramesh S, Christopher P, Velusamy A. A Case of Hand-Foot-Mouth Disease observed during Routine Dental Checkup in an Immunocompetent Healthy Adult Patient. J Health Sci Res 2017;8(1):42-45.

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Study on long noncoding RNA in enterovirus 71-induced severe hand-foot-mouth disease

10.21203/rs.3.rs-17306/v1 ◽

2020 ◽

Author(s):

Fang Fang ◽

He yi ◽

Xu feng

Keyword(s):

Long Noncoding Rna ◽

Noncoding Rna ◽

Target Gene ◽

Target Genes ◽

Enterovirus 71 ◽

Mouth Disease ◽

Differentially Expressed ◽

Kegg Analysis ◽

Hand Foot Mouth Disease ◽

Critical Type

Abstract Background: To identify the critical type of severe hand-foot-mouth disease (HFMD) in early stage, long noncoding ribonucleic acid (LncRNA) microarray was used to screen specific LncRNA and to predictpossible pathogenesis and target genes of HFMD. Methods: Twenty cases of EV71-induced severe HFMD were collected in Children’s Hospital of Chongqing Medical University from September 2015 to September 2016. LncRNA microarray was used to analyze the expression of LncRNA and mRNA in peripheral blood of children between severe type and critical type, and then verify the validity by real-time polymerase chain reaction. Bioinformatic methods were used to investigate differentially expressed mRNA by gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Results: We obtained differentially expressed profiles of LncRNA and mRNA from peripheral blood of children with EV71-induced severe HFMD, and the number of LncRNA was 1949, the total mRNA profiles were 1422. GO analysis found that differentially expressed mRNAs were involved in the processes of immune response, immune defense, nucleic acid metabolism, and protein and molecule binding. KEGG analysis revealed that the differentially expressed mRNAs were involved in the p53 signaling pathway, NOD-like receptor signaling pathway, osteoblast differentiation, and so on. The target gene SLPI was closely related to the critical type of severe HFMD by cis/trans target gene prediction, and the pathogenic processes was regulated by LncRNA NR_038337. Conclusion: Since differentially expressed LncRNAs and mRNAs are present in severe HFMD, our findings provide a new method to explore the pathogenesis of the critical type of severe HFMD, andfurther study on specific LncRNA and target genes in critical type has great significance for diagnosis and treatment of severe HFMD. Keywords: Long noncoding RNA; Enterovirus 71; Severe hand-foot-mouth disease; Target gene Trial registration:ChiCTR-DCD-15007192.Registered 8 October,2015, http://www.chictr.org.cn/ ChiCTR-DCD-15007192

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