scholarly journals Pathogenesis of hand-foot-mouth disease caused by enterovirus 71

2019 ◽  
Vol 27 (24) ◽  
pp. 1465-1472
Author(s):  
Chun-Rong Wang
Keyword(s):  
Enterovirus 71 ◽  
Mouth Disease ◽  
Hand Foot Mouth Disease

scholarly journals Study the current scenario of hand foot mouth disease an Indian prospective

2020 ◽  
Vol 7 (7) ◽  
pp. 1558
Author(s):  
Ravi Sahota ◽  
Navpreet Kaur ◽  
Gurpal Singh ◽  
Nisha Upadhyay
Keyword(s):  
Communicable Disease ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Neurological Complications ◽  
Mouth Disease ◽  
Human Enterovirus ◽  
Cross Sectional ◽  
Timely Initiation ◽  
Human Enterovirus 71 ◽  
Hand Foot Mouth Disease

Background: The hand-foot-mouth disease (HFMD) is an acute communicable disease, mostly affecting children under 5 years of age and caused by human enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16). The usual incubation period is 3 to 7 days. Early symptoms are likely to be fever often followed by a sore throat followed by loss of appetite and general malaise. Aim and objectives was to study the trend of hand foot and mouth disease in a private hospital in Uttarakhand over 5 successive years.Methods: This cross-sectional study was carried among 297 cases of HFMD newborn screened at pediatrics department of Sahota Super-specialty hospital, Kashipur, Uttarakhand during year 2015 to 2019 after ethical clearance of institutional ethical committee. Diagnosis is coded with ICD-10. SPSS version 20 was used to calculate frequencies and percentiles.Results: Almost 29 cases of HMFD were picked in 2015, 32 cases in 2016, 43 cases in 2017, 81 cases in 2018, 112 in 2019. Fever observed in 86% cases. Neurological complications were observed in 9 (3%) cases, pneumonitis in 14 (4.7%) cases, cardiomyopathy observed in 3 (<1%) case. One death was reported.Conclusions: It is vital to screen patients with HFMD for these abnormal clinical presentations, allowing timely initiation of appropriate interventions to reduce the mortality. Increased awareness about vaccination in a developing nation like India and vaccination program at the grass root levels have eradicated certain lethal diseases.

scholarly journals A Case of Hand-Foot-Mouth Disease observed during Routine Dental Checkup in an Immunocompetent Healthy Adult Patient

2017 ◽  
Vol 8 (1) ◽  
pp. 42-45
Author(s):  
Poorna Devadoss, ◽  
Skanda Ramesh, ◽  
Pradeep Christopher, ◽  
Anbu Velusamy
Keyword(s):  
Adult Patient ◽  
Hard Palate ◽  
Healthy Adult ◽  
Enterovirus 71 ◽  
Mouth Disease ◽  
Coxsackie Virus ◽  
Oral Lesions ◽  
Immunocompetent Adult ◽  
Patient Reported ◽  
Hand Foot Mouth Disease

ABSTRACT Signs of oral lesions are one of the initial indications for many major diseases. As we come across different lesions during routine dental checkups, we should be aware about the diseases associated with those lesions. A 47-year-old immunocompetent adult patient reported with small erythematous lesions in the hard palate and small ulcers in the tonsillar pillars and right buccal mucosa with mild pyrexia of 37.8°C. Maculopapular lesions were found on the palms and soles. He was diagnosed with hand-foot-mouth disease, which is caused by the following viruses: Enterovirus-71, Coxsackie Virus (CV)-16, CV-A6, and CV-A10. The severity of this condition leads to meningitis, paralytic polio, and onychomadesis (falling of nails). How to cite this article Devadoss P, Ramesh S, Christopher P, Velusamy A. A Case of Hand-Foot-Mouth Disease observed during Routine Dental Checkup in an Immunocompetent Healthy Adult Patient. J Health Sci Res 2017;8(1):42-45.

Study on long noncoding RNA in enterovirus 71-induced severe hand-foot-mouth disease

2020 ◽  
Author(s):  
Fang Fang ◽  
He yi ◽  
Xu feng
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Target Gene ◽  
Target Genes ◽  
Enterovirus 71 ◽  
Mouth Disease ◽  
Differentially Expressed ◽  
Kegg Analysis ◽  
Hand Foot Mouth Disease ◽  
Critical Type

Abstract Background: To identify the critical type of severe hand-foot-mouth disease (HFMD) in early stage, long noncoding ribonucleic acid (LncRNA) microarray was used to screen specific LncRNA and to predictpossible pathogenesis and target genes of HFMD. Methods: Twenty cases of EV71-induced severe HFMD were collected in Children’s Hospital of Chongqing Medical University from September 2015 to September 2016. LncRNA microarray was used to analyze the expression of LncRNA and mRNA in peripheral blood of children between severe type and critical type, and then verify the validity by real-time polymerase chain reaction. Bioinformatic methods were used to investigate differentially expressed mRNA by gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Results: We obtained differentially expressed profiles of LncRNA and mRNA from peripheral blood of children with EV71-induced severe HFMD, and the number of LncRNA was 1949, the total mRNA profiles were 1422. GO analysis found that differentially expressed mRNAs were involved in the processes of immune response, immune defense, nucleic acid metabolism, and protein and molecule binding. KEGG analysis revealed that the differentially expressed mRNAs were involved in the p53 signaling pathway, NOD-like receptor signaling pathway, osteoblast differentiation, and so on. The target gene SLPI was closely related to the critical type of severe HFMD by cis/trans target gene prediction, and the pathogenic processes was regulated by LncRNA NR_038337. Conclusion: Since differentially expressed LncRNAs and mRNAs are present in severe HFMD, our findings provide a new method to explore the pathogenesis of the critical type of severe HFMD, andfurther study on specific LncRNA and target genes in critical type has great significance for diagnosis and treatment of severe HFMD. Keywords: Long noncoding RNA; Enterovirus 71; Severe hand-foot-mouth disease; Target gene Trial registration:ChiCTR-DCD-15007192.Registered 8 October,2015, http://www.chictr.org.cn/ ChiCTR-DCD-15007192

Epidemiologic Features of Hand-Foot-Mouth Disease and Herpangina Caused by Enterovirus 71 in Taiwan, 1998 2005

PEDIATRICS ◽  
2007 ◽  
Vol 120 (2) ◽  
pp. e244-e252 ◽  
Author(s):  
K.-T. Chen ◽  
H.-L. Chang ◽  
S.-T. Wang ◽  
Y.-T. Cheng ◽  
J.-Y. Yang
Keyword(s):  
Enterovirus 71 ◽  
Mouth Disease ◽  
Hand Foot Mouth Disease ◽  
Epidemiologic Features

scholarly journals Relationship between polymorphism of receptor SCARB2 gene and clinical severity of enterovirus-71 associated hand-foot-mouth disease

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Xia Wang ◽  
Hong Liu ◽  
Ying Li ◽  
Rui Su ◽  
Yamin Liu ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Enterovirus 71 ◽  
Mouth Disease ◽  
Clinical Severity ◽  
Control Group ◽  
Case Group ◽  
Hand Foot Mouth Disease ◽  
The Relationship

Abstract Background To investigate the relationship between polymorphism of scavenger receptor class B member 2 (SCARB2) gene and clinical severity of enterovirus (EV)-71 associated hand-foot-mouth disease (HFMD). Methods Among the 100 recruited cases, 56 were in the severe HFMD group (case group) and 44 were in the general HFMD group (control group). By screening functional single nucleotide polymorphisms (SNPs) and hot SNPs, and performing SNP site optimization, some SNP sites of SCARB2 gene were selected for analysis. Genotyping was performed using a MassArray platform. PLINK software was used for statistical processing and analysis of the correlation differences between the mutant genotypes in the severe and general HFMD groups. The relationship between the SNPs and clinical severity of enterovirus (EV)-71 associated HFMD was assessed. Results 28 SNPs in SCARB2 were selected by site optimization. Then three loci were not in agreement with the minor allele frequency (MAF) in the 1000 Han Chinese in Beijing (CHB) dataset. Another three loci could not be detected. Nine loci were not suitable for further analysis (MAF < 0.01 and Hardy–Weinberg [HWE] P < 0.001). A total of 13 sites were subsequently analyzed. Through Fisher analysis, the frequency of the rs6812193 T allele was 0.134 and 0.034 in the severe and general HFMD groups, respectively (P 0.023 < 0.05, odds ratio [OR] 4.381 > 1). Logistic regression analysis of rs6812193 T alleles between the severe and general HFMD groups, respectively (P 0.023 < 0.05, OR 4.412 > 1, L95 1.210 > 1). Genotype logistic regression analysis of the rs6812193 alleles CT + TT versus CC gave an OR of 4.56 (95% confidence interval [95% CI] 1.22–17.04, P = 0.012). Conclusion The rs6812193 T allele was a susceptibility SNP for SHFMD, and the rs6812193 polymorphism might be significantly associated with the susceptibility to EV-71 infection.

scholarly journals Risk factors for death from hand–foot–mouth disease: a meta-analysis

2020 ◽  
Vol 148 ◽  
Author(s):  
X.F. Ni ◽  
X. Li ◽  
C. Xu ◽  
Q. Xiong ◽  
B.Y. Xie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Meta Analysis ◽  
Enterovirus 71 ◽  
Mouth Disease ◽  
Human Enterovirus ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Human Enterovirus 71 ◽  
Study Heterogeneity ◽  
Hand Foot Mouth Disease

Abstract In recent years, outbreaks of hand–foot–mouth disease (HFMD) in China, Singapore and other Western Pacific Region, involving millions of children, have become a big threat to public health. This study aimed to quantitatively assess all qualified studies and identify the risk factors for HFMD death. A systematic search of the databases PubMed, Medline, Embase and the Cochrane Library was performed. Study heterogeneity and publication bias were estimated. Seven case–control studies involving 1641 participants (634 died and 1007 survived) were included in the meta-analysis. Human enterovirus 71 infection, male, age ⩽3 years, vomiting, cyanosis, convulsion, duration of fever ⩾3 days, atypical rashes and abdominal distention were not significantly related to HFMD death (P ⩽ 0.05). Lethargy (odds ratio (OR) = 6.62; 95% CI 3.61–12.14; I2 = 0%; P < 0.0001), pneumonoedema/pneumorrhagia (OR = 4.09; 95% CI 2.44–6.87; I2 = 0%; P < 0.0001), seizures (OR = 6.85; 95% CI 2.37–19.74; I2 = 0%; P = 0.0004), dyspnoea (OR = 8.24; 95% CI 2.05–33.19; I2 = 83%; P = 0.003) and coma (OR = 3.76; 95% CI 1.85–7.67; I2 = 0%; P = 0.0003) were significantly associated with HFMD death, which were risk factors for HFMD death.

The Seroprevalence of Hand-Foot-Mouth Disease in Preschool Children

2019 ◽  
Vol 14 (04) ◽  
pp. 171-175
Author(s):  
Esma Merve Cinar ◽  
Mustafa Kosecik ◽  
Ferhat Gurkan Aslan ◽  
Mustafa Buyukavcı ◽  
Mehmet Koroglu ◽  
...  
Keyword(s):  
Preschool Children ◽  
Specific Treatment ◽  
Enterovirus 71 ◽  
Clinical Findings ◽  
Mouth Disease ◽  
Igg Antibody ◽  
Preschool Period ◽  
The Status ◽  
Antibody Positivity ◽  
Hand Foot Mouth Disease

AbstractHand-foot-mouth disease (HFMD) is a systemic and mostly uncomplicated infectious disease caused by the virus of the enterovirus family and manifests as skin and mucosal lesions. Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the most commonly detected infectious agents. It is generally observed in children under 5 years of age. In this study, our objective was to determine the seroprevalence of HFMD in preschool children in Sakarya region. A total of 380 children between 1 and 6 years of age were included in the study. Sociodemographic information, clinical findings, and possible risk factors were recorded on a data collection form. Later, serum anti-EV71 and anti-CA16 IgG (immunoglobulin G) antibodies were measured by ELISA. Amongst the 380 children, EV71 IgG positivity was 57.9% and CA16 IgG antibody positivity was 57.4%. There was no difference in seroprevalence between the genders (p > 0.05). Anti-EV71 and anti-CA16 IgG antibody positivity was significantly higher in children aged 1, 2, 3, and 4 years than in 5-year olds (p < 0.05). Seroprevalence was significantly lower in children of mothers who washed their hands before feeding (p < 0.01). High HFMD seroprevalence (> 50%) was observed in the preschool period in the Sakarya region, especially in children aged 1 to 4 years. To prevent infections for which there is no specific treatment, it is very important that the hygiene rules are complied with; in particular, children and their caregivers should pay attention to hand cleansing. We believe that more seroprevalence studies should be performed from different regions to show the status of the disease in our country.

Sign in / Sign up

Export Citation Format

Share Document