scholarly journals The clinical profile of native-valve infective endocarditis in a tertiary hospital in the Philippines: a twelve-year retrospective study

2019 ◽  
Vol 79 ◽  
pp. 47-48
Author(s):  
A.D.S. Juson ◽  
J. Delgado
Keyword(s):  
Retrospective Study ◽  
Infective Endocarditis ◽  
Tertiary Hospital ◽  
The Philippines ◽  
Clinical Profile ◽  
Native Valve

Changes in Clinical Profile, Epidemiology and Prognosis of Left-sided Native-valve Infective Endocarditis Without Predisposing Heart Conditions

2015 ◽  
Vol 68 (5) ◽  
pp. 445-448 ◽  
Author(s):  
Francisco J. Castillo ◽  
Manuel Anguita ◽  
Juan C. Castillo ◽  
Martín Ruiz ◽  
Dolores Mesa ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Clinical Profile ◽  
Native Valve

Abstract TP276: Stroke in Infective Endocarditis: Impact of Management on Outcome Over 3 Decades

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Oguzhan Kursun ◽  
Mehmet A Topcuoglu ◽  
Hulya Karatas ◽  
Ferdinando S Buonanno ◽  
Aneesh B Singhal
Keyword(s):  
Infective Endocarditis ◽  
Tertiary Hospital ◽  
Stroke Patients ◽  
Native Valve ◽  
Death Rates ◽  
Patient Demographics ◽  
Diagnostic Codes ◽  
Duke Criteria ◽  
Stroke Type ◽  
Large Retrospective Study

Background: Stroke is a common, serious complication of infective endocarditis (IE). It is not known how recent advances in management have changed the profile and outcome of IE-related stroke. Methods: We retrospectively reviewed data of all inpatients with ICD-9 diagnostic codes of IE admitted to our tertiary hospital from 1980-2011. Original Duke Criteria were used to confirm the diagnosis. Data was compared over 3 time epochs: 1980-1990 (E1), 1991-2000 (E2) and 2001-2011 (E3). Results: Of 1151 hospitalizations (1083 adults), 277 included IE-related stroke (76% ischemic, 13% hemorrhagic, 10% both). There was an increasing rate of stroke over the 3 epochs (E1 25%, E2 30%, E3 45%; p<0.001), perhaps due to increased detection from increasing MRI use (E1 6%, E2 27%, E3 67%; p<0.001). Stroke patients had mean age 56 yrs, 63% male, 93% definite IE per Duke Criteria and 83% native valve infection. Organism types were staph 40%, strep 30% and other 30%. Trans-esophageal echo was performed in 53%. Over time there was no change in age, gender, and organism type; however there was an increasing frequency of native valve infection (E1 74%, E2 82%, E3 88%; p=0.04), ‘definite’ IE (E1 80%, E2 94%, E3 100%; p<0.001), cardiovascular risk factors (hypertension, diabetes, etc), and more patients underwent TEE (E1 9%, E2 67%, E3 68%; p<0.001). Brain imaging showed higher detection of multiple (vs. single) lesions (E1 67%, E2 66%, E3 88%; p<0.001), and ischemic (vs. hemorrhagic) strokes (E1 74%, E2 84%, E3 95%; p<0.001), presumably due to increasing MRI use, although the frequency of anticoagulant use also decreased (E1 45%, E2 35%, E3 26%; p=0.04). There was a trend towards improved outcome (p=0.12) with fewer deaths in 2001-2011 vs. 1980-2000 (22% vs. 33%; p=0.06). Logistic regression showed that age, anticoagulant use, stroke type, MRI performance, but not organism type or time epoch, predicted death at discharge. Conclusion: This large retrospective study spanning 3 decades shows important changes in the profile of IE-related stroke. While patient demographics and organism type appear unchanged, there is a higher rate of stroke detection and lower rates of complications such as brain hemorrhage and death rates, suggesting efficacy of recent diagnostic and management advances.

scholarly journals Clinical Profile and Treatment Outcome of Culture-negative Infective Endocarditis in Children at UP-PGH: A Ten-year Retrospective Study

2019 ◽  
Vol 53 (1) ◽  
Author(s):  
Mylah P. Alfeche ◽  
Ma. Concepcion S. Sison
Keyword(s):  
Retrospective Study ◽  
Infective Endocarditis ◽  
Clinical Presentation ◽  
Demographic Data ◽  
Antibiotic Use ◽  
Unfavorable Outcome ◽  
Clinical Profile ◽  
Penicillin G ◽  
Exact Test ◽  
Echocardiographic Findings

Objective. This study determined the demographic data, clinical profile, treatment and outcome of BCN-IE in children at UP-PGH. Methods. This is a retrospective study of children with BCN-IE admitted at UP-PGH from 2004-2013. Demographic data, clinical presentation, previous antibiotic use, echocardiographic findings, an antibiotic used and outcome of patients were recorded and analyzed. Results in the demographic and clinical profile were expressed as frequencies, percentages and means. To compare the clinical features, echocardiographic findings and antibiotic regimen used as to the outcome, Fischer’s exact test was used. Results. Among 91 patients diagnosed with infective endocarditis, 61.54% had BCN-IE. The age, gender and clinical presentation were similar to other studies. Clinical presentation and echocardiographic findings did not have influence on outcome of children with BCN-IE. The use of penicillin G and amikacin is associated with unfavorable outcome after 4 weeks or less of administration. Conclusion. The incidence of BCN-IE is high in UP-PGH. The demographic distribution, clinical and echocardiographic features of patients do not have an influence on the outcome. The trend to the unfavorable outcome with the use of penicillin suggests the need to target fastidious organisms in BCN-IE. Further investigation is warranted to establish the etiologic agents of BCN-IE.

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