A risk score for prediction of symptomatic intracerebral haemorrhage following thrombolysis

2021 ◽  
Vol 156 ◽  
pp. 104586
Author(s):  
Mukesh Soni ◽  
Tissa Wijeratne ◽  
David C. Ackland
Keyword(s):  
Risk Score ◽  
Intracerebral Haemorrhage ◽  
Symptomatic Intracerebral Haemorrhage

scholarly journals Intravenous thrombolysis with 0.9 mg/kg alteplase for acute ischaemic stroke: a network meta-analysis of treatment delay

2019 ◽  
Vol 96 (1141) ◽  
pp. 680-685
Author(s):  
Xi Chen ◽  
Yu Shen ◽  
Chengfang Huang ◽  
Yu Geng ◽  
Yunxian Yu
Keyword(s):  
Ischaemic Stroke ◽  
Intracerebral Haemorrhage ◽  
Acute Ischaemic Stroke ◽  
Meta Analysis ◽  
Time Windows ◽  
Intravenous Thrombolysis ◽  
Treatment Delay ◽  
Cochrane Library ◽  
Randomised Controlled ◽  
Symptomatic Intracerebral Haemorrhage

ObjectivesThe aim of this study was to evaluate the effect of alteplase in intravenous thrombolysis of acute ischaemic stroke (AIS) regarding the different time windows of treatment (<3 hours, 3–4.5 hours, >4.5 hours).MethodsA systematic literature search was conducted from PubMed, Cochrane Library and Embase. 12 clinical randomised controlled trials with 3402 patients with AIS met the inclusion criteria. The primary, secondary and tertiary outcomes were modified Rankin Scale (mRS) scores 0–1, mortality at 90th day after treatment and symptomatic intracerebral haemorrhage within 36 hours, respectively. Network meta-analysis and conventional meta-analysis were carried out for calculating odds ratio (OR), the surface under cumulative ranking curve (SUCRA) and the probabilities of being the best.ResultsFor mRS, alteplase regardless of time delay was significantly more effective than placebo (OR 1.33–2.17). However, alteplase used within 3 hours after AIS occurrence (SUCRA=98.3%) was significantly more effective (OR=1.64) than that at 3–4.5 hours (SUCRA=43%) and showed the trend of priority (OR=1.47) compared with that beyond 4.5 hours (SUCRA=58%). For the mortality, compared with placebo (SUCRA=64.7%), alteplase within 3 hours was similar to that of 3–4.5 hours whereas alteplase beyond 4.5 hours (SUCRA=7.3%) showed the trend of significantly increasing 85% mortality. For the tertiary outcome, alteplase within 3 hours (SUCRA=19.0%) was comparable with placebo (SUCRA=99.9%) whereas alteplase beyond 3 hours significantly increased (OR 5.89–6.67) the symptomatic intracerebral haemorrhage.ConclusionsAlteplase within 3 hours should be recommended as the best treatment delay for its best efficacy among all the intervention and equivalent safety compared with placebo. Alteplase beyond 3 hours was less effective compared with that within 3 hours and increased the risk of mortality on 3 months as well as symptomatic intracerebral haemorrhage at 36 hours. More head-to-head clinical trials are needed to confirm those findings.

Time to recanalization and risk of symptomatic intracerebral haemorrhage in patients treated with intravenous thrombolysis

2012 ◽  
Vol 19 (9) ◽  
pp. 1251-1255 ◽  
Author(s):  
L. Dorado ◽  
M. Millán ◽  
N. Pérez de la Ossa ◽  
C. Guerrero ◽  
M. Gomis ◽  
...  
Keyword(s):  
Intracerebral Haemorrhage ◽  
Intravenous Thrombolysis ◽  
Symptomatic Intracerebral Haemorrhage

scholarly journals Viper snakebite causing symptomatic intracerebral haemorrhage

2004 ◽  
Vol 251 (7) ◽  
Author(s):  
Deborah Bartholdi ◽  
Claudia Selic ◽  
J�rg Meier ◽  
HansH. Jung
Keyword(s):  
Intracerebral Haemorrhage ◽  
Symptomatic Intracerebral Haemorrhage

Leukoaraiosis is a risk factor for symptomatic intracerebral haemorrhage after thrombolysis for acute stroke

2006 ◽  
Vol 33 (S 1) ◽  
Author(s):  
T. Neumann-Haefelin ◽  
S. Hölig ◽  
J. Berkefeld ◽  
J. Fiehler ◽  
A. Gass ◽  
...  
Keyword(s):  
Risk Factor ◽  
Acute Stroke ◽  
Intracerebral Haemorrhage ◽  
Symptomatic Intracerebral Haemorrhage

Abstract # OR-20: External Validation of the Leicester Self-Assessment Diabetes Risk Score in a Population with Intellectual Disability

2016 ◽  
Vol 22 ◽  
pp. 12
Author(s):  
Laura Gray ◽  
Yogini Chudasama ◽  
Alison Dunkley ◽  
Freya Tyrer ◽  
Rebecca Spong ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Risk Score ◽  
External Validation ◽  
Diabetes Risk ◽  
Self Assessment ◽  
Diabetes Risk Score
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