Use of autogenous bone and beta-tricalcium phosphate in maxillary sinus lifting: a prospective, randomized, volumetric computed tomography study

Background: Due to the lack of data comparing the biological behavior of two formulations, granules and paste, of alloplastic graft from microtomographic and histomorphometric points of view, the aim of the present experiment was to compare the histomorphometric and microtomographic healing of two formulations, i.e., granules (MR sites) or paste (MR-inject sites) of an alloplastic graft composed of a combination of beta-tricalcium phosphate and hydroxyapatite used for maxillary sinus lifting. Methods: A sinus lifting procedure was carried out bilaterally in 20 rabbits, and the elevated space was filled with either paste or granules of an alloplastic material. A collagen membrane was placed on the antrostomy and the animals were euthanized after 2 or 10 weeks, 10 animals each group. Microtomographic and histological analyses were performed. Results: Higher proportions of new bone formation were found at the MR, compared to the MR-inject sites both after 2 weeks (2.65 ± 2.89% vs. 0.08 ± 0.12%; p < 0.01) and 10 weeks of healing (34.20 ± 13.86 vs. 23.28 ± 10.35%; p = 0.022). Conclusions: It was concluded that new bone formation was faster in the MR sites, compared to the MR-inject. However, a longer time of healing should be allowed to make final conclusions about the efficiency in bone formation of the paste formulation of the biomaterial used in the present study.

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Histomorphometric Comparison of New Bone Formed After Maxillary Sinus Lift With Lateral and Crestal Approaches Using Periostal Mesenchymal Stem Cells and Beta-Tricalcium Phosphate

Journal of Craniofacial Surgery ◽

10.1097/scs.0000000000008319 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Valentina Fatale ◽

Stefano Pagnoni ◽

Albino Emidio Pagnoni ◽

Pier Carmine Passarelli ◽

Andrea Netti ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Maxillary Sinus ◽

Tricalcium Phosphate ◽

Sinus Lift ◽

Beta Tricalcium Phosphate

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Biologic Responses of Autogenous Bone and Beta-tricalcium Phosphate Ceramics Transplanted into Bone Defects to Orthodontic Forces

The Cleft Palate-Craniofacial Journal ◽

10.1597/1545-1569(1996)033<0277:broaba>2.3.co;2 ◽

1996 ◽

Vol 33 (4) ◽

pp. 277-283 ◽

Cited By ~ 26

Author(s):

Mohammed Zakir Hossain ◽

Shingo Kyomen ◽

Kazuo Tanne

Keyword(s):

Tricalcium Phosphate ◽

Bone Defects ◽

Autogenous Bone ◽

Beta Tricalcium Phosphate ◽

Orthodontic Forces

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Correlation of Fractal Dimension with Histomorphometry in Maxillary Sinus Lifting Using Autogenous Bone Graft

Brazilian Dental Journal ◽

10.1590/0103-6440201300290 ◽

2015 ◽

Vol 26 (1) ◽

pp. 11-18 ◽

Cited By ~ 11

Author(s):

Rafael Scaf de Molon ◽

Wagner Nunes de Paula ◽

Rubens Spin-Neto ◽

Mario Henrique Arruda Verzola ◽

Guilherme Monteiro Tosoni ◽

...

Keyword(s):

Fractal Dimension ◽

Maxillary Sinus ◽

Bone Remodeling ◽

Volume Fraction ◽

Autogenous Bone ◽

Histomorphometric Analysis ◽

Significant Difference ◽

Sinus Lifting ◽

Group 3 ◽

Group 1

The aim of this study was to determine the pattern of bone remodeling after maxillary sinus lifting in humans by means of fractal dimension (FD) and histomorphometric analysis. Therefore, the correlation between FD and the histomorphometric findings was evaluated. Sixteen patients with posterior edentulous maxilla were enrolled in this study. Maxillary sinus lifting was performed using autogenous bone grafted from the mandibular retromolar area. Three direct digital panoramic radiographs were obtained: before surgery (Group 1), immediately postoperatively (Group 2) and after 6 months of healing (Group 3) for FD analysis. Biopsies were taken after 6 months, processed and submitted to histological and histomorphometric analysis. Data were analyzed by Shapiro-Wilk test and ANOVA test followed by a Tukey test (a=0.05). The bone volume fraction of newly trabecular bone (TB) and medullary area (MA) was measured as 62.75%±17.16% and 37.25±17.16%, respectively. Significant difference in FD analysis was measured between Group 1 and Group 3. No significant difference was found in the correlation between FD and histomorphometric analysis for TB and MA (p=0.84). In conclusion, all performed analyses were effective in assessing the bone-remodeling pattern in the maxillary sinus, offering complementary information about healing and predictable outcomes. There were no correlations between FD and histomorphometric analysis.

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