scholarly journals Maxillary Sinus Augmentation Using Ceramic Alloplastic Granules or Paste: An Experimental Study in Rabbits

2021 ◽  
Vol 9 (6) ◽  
pp. 65
Author(s):  
Michael Medeiros Costa ◽  
Daniele Botticelli ◽  
Ofer Moses ◽  
Yuki Omori ◽  
Shigeo Fujiwara ◽  
...  
Keyword(s):  
Bone Formation ◽  
Maxillary Sinus ◽  
Biological Behavior ◽  
Collagen Membrane ◽  
Alloplastic Material ◽  
New Bone Formation ◽  
Sinus Augmentation ◽  
Beta Tricalcium Phosphate ◽  
Sinus Lifting ◽  
Points Of View

Background: Due to the lack of data comparing the biological behavior of two formulations, granules and paste, of alloplastic graft from microtomographic and histomorphometric points of view, the aim of the present experiment was to compare the histomorphometric and microtomographic healing of two formulations, i.e., granules (MR sites) or paste (MR-inject sites) of an alloplastic graft composed of a combination of beta-tricalcium phosphate and hydroxyapatite used for maxillary sinus lifting. Methods: A sinus lifting procedure was carried out bilaterally in 20 rabbits, and the elevated space was filled with either paste or granules of an alloplastic material. A collagen membrane was placed on the antrostomy and the animals were euthanized after 2 or 10 weeks, 10 animals each group. Microtomographic and histological analyses were performed. Results: Higher proportions of new bone formation were found at the MR, compared to the MR-inject sites both after 2 weeks (2.65 ± 2.89% vs. 0.08 ± 0.12%; p < 0.01) and 10 weeks of healing (34.20 ± 13.86 vs. 23.28 ± 10.35%; p = 0.022). Conclusions: It was concluded that new bone formation was faster in the MR sites, compared to the MR-inject. However, a longer time of healing should be allowed to make final conclusions about the efficiency in bone formation of the paste formulation of the biomaterial used in the present study.

scholarly journals Influence of the Use of a Collagen Membrane Placed on the Bone Window after Sinus Floor Augmentation—An Experimental Study in Rabbits

2021 ◽  
Vol 9 (11) ◽  
pp. 131
Author(s):  
Alessandro Perini ◽  
Jose Viña-Almunia ◽  
Carmen Carda ◽  
José Javier Martín de Llano ◽  
Daniele Botticelli ◽  
...  
Keyword(s):  
Bone Formation ◽  
Maxillary Sinus ◽  
Osteotomy Site ◽  
Collagen Membrane ◽  
New Bone Formation ◽  
Sinus Augmentation ◽  
Sinus Floor Augmentation ◽  
Sinus Floor ◽  
Window Region ◽  
Sinus Grafting

Background: We studied the influence on healing of a resorbable membrane covering the osteotomy site after maxillary sinus grafting, evaluated in different regions of the augmented area. Methods: Maxillary sinus augmentation was performed in 24 New Zealand rabbits. Osteotomy, 4 × 6 mm, were performed bilaterally. A collagenated cortico-cancellous porcine bone was used to fill the elevated region. A collagen membrane was randomly placed over the osteotomy site on one side (MG), and the other side was left uncovered (NMG). The animals were euthanized after 2, 4, and 8 weeks; and histomorphometric analysis was performed in eight different regions. Results: New bone percentages were similar in both groups. There were no statistically significant differences. In MG, the overall percentages were 15.6 ± 7.3%, 22.9 ± 6.1%, and 24.9 ± 12.0% after 2, 4, and 8 weeks, respectively. In NMG, the percentages were 11.2 ± 4.5%, 24.1 ± 5.7%, and 24.5 ± 15.7%, respectively. The proportions of new bone in the various regions after 8 weeks were 31 ± 8.9% and 29.9 ± 9.1% in the bone walls region, 25 ± 10.1% and 32.8 ± 9.1% in the submucosa region, 22.6 ± 21.6% and 10.9 ± 11.5 in the middle region, 17.3 ± 14% and 13.4 ± 9.8% in the close-to-window region, and 21.8 ± 11.6%, 19.1 ± 6.4% in the osteotomy region—for MG and NMG, respectively. Conclusions: In both groups the greatest amounts of bone formation occurred near to the pre-existing bone walls, followed by the sub-mucosa region. The smallest amounts were found in the close-to-window region, followed by the central region. The placement of a collagen membrane to cover the osteotomy site did not influence the amount of new bone formation after sinus grafting.

scholarly journals Histologic, Histomorphometric, and Clinical Analysis of the Effects of Growth Factors in a Fibrin Network Used in Maxillary Sinus Augmentation

2020 ◽  
Vol 17 (6) ◽  
pp. 1918
Author(s):  
Ihsan Caglar Cinar ◽  
Bahattin Alper Gultekin ◽  
Alper Saglanmak ◽  
Serdar Yalcin ◽  
Vakur Olgac ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bone Formation ◽  
Maxillary Sinus ◽  
Clinical Analysis ◽  
Controlled Clinical Trial ◽  
New Bone Formation ◽  
Sinus Augmentation ◽  
Volume Stability ◽  
Fibrin Network ◽  
Significant Difference

This randomized controlled clinical trial evaluated the effect of mineralized plasmatic matrix (MPM), comprised of synthetic graft and platelet concentrates, on new bone formation and volume stability over time in maxillary sinus lifting (MSL). Unilateral MSL was performed in 20 patients with either beta-tricalcium phosphate (β-TCP) or MPM grafts (10 sinuses each). Six months postsurgery, specimens were obtained with a trephine bur prior to implant placement in 39 cases. Volumetric changes in sinus augmentation were analyzed between 1 week (T-I) and 6 months (T-II) postsurgery. Histomorphometric and histological analyses of biopsy samples revealed mean new bone percentages of 35.40% ± 9.09% and 26.92% ± 7.26% and residual graft particle areas of 23.13% ± 6.16% and 32.25% ± 8.48% in the MPM and β-TCP groups, respectively (p < 0.05). The mean soft-tissue areas in the MPM and β-TCP groups were 41.48% ± 8.41% and 40.83% ± 8.86%, respectively (p > 0.05). Graft reductions between baseline and 6-months postprocedure in the β-TCP and MPM groups were 17.12% ± 13.55% and 14.41% ± 12.87%, respectively, with significant graft volume reduction observed in both groups (p < 0.05) while there is no significant difference between MPM and β-TCP groups (p > 0.05). Thus, MPM, representing growth factors in a fibrin network, increases new bone formation and has acceptable volume stability in MSL procedures

Human Histologic Evaluation of the Use of the Dental Putty for Bone Formation in the Maxillary Sinus: Case Series

2012 ◽  
Vol 38 (4) ◽  
pp. 391-398 ◽  
Author(s):  
David M. Kim ◽  
Myron Nevins ◽  
Marcelo Camelo ◽  
Marc L. Nevins ◽  
Peter Schupbach ◽  
...  
Keyword(s):  
Bone Formation ◽  
Maxillary Sinus ◽  
Case Series ◽  
Osteotomy Site ◽  
Collagen Membrane ◽  
Loose Connective Tissue ◽  
Sinus Augmentation ◽  
Implant Placement ◽  
Histologic Evaluation ◽  
Mucoperiosteal Flap

A proof-of-principle study was conducted to assess the safety and efficacy of dental putty as an alternative sinus augmentation biomaterial. Six healthy patients requiring a total of 10 sinus augmentations received sinus augmentations. All patients volunteered and signed an informed consent based on the Helsinki declaration of 1975, as revised in 2000. The sinus augmentation was performed under local anesthesia with a mucoperiosteal flap elevated to expose the buccal wall of the maxillary sinus. The space was then filled with the dental putty in several increments, and the window was covered with an absorbable collagen membrane. Biopsies were harvested from all 10 treated sinuses using a 3-mm trephine bur at the time of implant placement at either 6 or at 9 months after sinus augmentation. All patients completed the study without complications, except for 1 patient who reported fistulas at 1 and 2 months after the surgery. Clinical reentry revealed that regenerated bone on the osteotomy site was soft and immature. The ground sections of the biopsied cores revealed minimum amounts of trabeculation surrounded by an abundant array of irregular-shaped residual alloplastic particles embedded in loose connective tissue. The present study's findings revealed inadequate bone formation, although the material appears to be bioinert as there is no elicitation of inflammatory response.

Comparison of New Bone Formation and Osteotomy Speed in the Rabbit Mandible Using Piezoelectric Surgery and Conventional Burs

2007 ◽  
Vol 361-363 ◽  
pp. 1257-1260 ◽  
Author(s):  
K.H. Yun ◽  
S.G. Kim ◽  
Sung Chul Lim
Keyword(s):  
Bone Formation ◽  
Light Microscopy ◽  
Maxillary Sinus ◽  
Bone Healing ◽  
Healing Process ◽  
New Bone Formation ◽  
Piezoelectric Surgery ◽  
Sinus Lifting ◽  
Time Required ◽  
Early Healing

We compared the effect of osteotomies performed using piezoelectric surgery (Piezosurgery®) and the conventional bur method on new bone formation in the rabbit mandible, focusing on light-microscopy observations of the early healing process after 1, 2, and 4 weeks. The time required to perform the osteotomy was also compared. We showed that piezoelectric surgery and the conventional bur method had no marked difference on early bone healing, although the osteotomy time was shorter with the conventional bur method than with Piezosurgery. Because the instrument used in Piezosurgery is sharp and more controllable, piezoelectric surgery should be more useful for delicate surgery, such as maxillary sinus lifting and segmental osteotomies, with the fewest complications.

Bioglass Associated With Leukocyte-Poor Platelet-Rich Plasma in the Rabbit Maxillary Sinus: Histomorphometric, Densitometric, and Fractal Analysis

2010 ◽  
Vol 36 (5) ◽  
pp. 333-343 ◽  
Author(s):  
Ivy Kiemle Trindade-Suedam ◽  
Juliana Aparecida Najarro Dearo de Morais ◽  
Rafael Silveira Faeda ◽  
Fábio Renato Manzolli Leite ◽  
Guilherme Monteiro Tosoni ◽  
...  
Keyword(s):  
Fractal Dimension ◽  
Bone Density ◽  
Bone Formation ◽  
Maxillary Sinus ◽  
Platelet Rich Plasma ◽  
Autogenous Bone ◽  
New Bone Formation ◽  
Mean Values ◽  
Dimension Analysis ◽  
Fractal Dimension Analysis

Abstract The objective of the present study was to evaluate the outcomes of autogenous bone graft (AB) and bioglass (BG) associated or not with leukocyte-poor platelet-rich plasma (LP-PRP) in the rabbit maxillary sinus (MS) by histomorphometric and radiographic analysis. Twenty rabbits divided into 2 groups (G1, G2) were submitted to sinus lift surgery. In G1, 10 MS were grafted with AB and 10 MS were grafted with BG. In G2, 10 MS were grafted with AB + LP-PRP and 10 MS were grafted with BG + LP-PRP. After 90 days, the animals were killed and specimens were obtained, x-rayed, and submitted to histomorphometric, radiographic bone density (RD) and fractal dimension analysis. Radiographic bone density mean values (SD), expressed as aluminum equivalent in mm, of AB, BG, AB + LP-PRP, and BG + LP-PRP groups were 1.79 (0.31), 2.04 (0.39), 1.61 (0.28), and 1.53 (0.30), respectively. Significant differences (P &lt; 0.05) were observed between BG and AB, and BG + PRP and BG. Fractal dimension mean values were 1.48 (0.04), 1.35 (0.08), 1.44 (0.04), and 1.44 (0.06), respectively. Significant differences were observed between BG and AB, and AB + LP-PRP and BG. Mean values for the percentage of bone inside MS were 63.30 (8.60), 52.65 (10.41), 55.25 (7.01), and 51.07 (10.25), respectively. No differences were found. No correlations were observed among percentage of bone, RD and FD. Histological analysis showed that MS treated with AB presented mature and new bone formation. The other groups showed minor bone formation. Within the limitations of this study, the results indicated that at a 90-day time end point, AB yielded better results than AB + LP-PRP, BG, and BG + LP-PRP and should be considered the primary material for MS augmentation.

Influence of Maxillary Sinus Width on New Bone Formation After Transcrestal Sinus Floor Elevation

2017 ◽  
Vol 26 (2) ◽  
pp. 209-216 ◽  
Author(s):  
Teresa Lombardi ◽  
Claudio Stacchi ◽  
Federico Berton ◽  
Tonino Traini ◽  
Lucio Torelli ◽  
...  
Keyword(s):  
Bone Formation ◽  
Maxillary Sinus ◽  
New Bone Formation ◽  
Sinus Floor Elevation ◽  
Sinus Floor
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