scholarly journals Resistance of Leishmania infantum to allopurinol is associated with chromosome and gene copy number variations including decrease in the S-adenosylmethionine synthetase (METK) gene copy number

2018 ◽  
Vol 8 (3) ◽  
pp. 403-410 ◽  
Author(s):  
Daniel Yasur-Landau ◽  
Charles L. Jaffe ◽  
Lior David ◽  
Adi Doron-Faigenboim ◽  
Gad Baneth
Keyword(s):  
Leishmania Infantum ◽  
Copy Number ◽  
Gene Copy Number ◽  
Copy Number Variations ◽  
Gene Copy ◽  
Adenosylmethionine Synthetase

scholarly journals Parallel selection on gene copy number variations through evolution of three-spined stickleback genomes

BMC Genomics ◽  
2014 ◽  
Vol 15 (1) ◽  
pp. 735 ◽  
Author(s):  
Shotaro Hirase ◽  
Haruka Ozaki ◽  
Wataru Iwasaki
Keyword(s):  
Copy Number ◽  
Gene Copy Number ◽  
Copy Number Variations ◽  
Gene Copy ◽  
Parallel Selection

Abstract 3098: ERCC1 gene copy number variations in resected non-small cell lung cancer

2012 ◽  
Author(s):  
Luc Friboulet ◽  
Ken A. Olaussen ◽  
Alexander Valent ◽  
Ximing Tang ◽  
Tao Tang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Copy Number ◽  
Gene Copy Number ◽  
Copy Number Variations ◽  
Small Cell ◽  
Gene Copy ◽  
Small Cell Lung

Associations of MYH3 gene copy number variations with transcriptional expression and growth traits in Chinese cattle

Gene ◽  
2014 ◽  
Vol 535 (2) ◽  
pp. 106-111 ◽  
Author(s):  
Yao Xu ◽  
Tao Shi ◽  
Hanfang Cai ◽  
Yang Zhou ◽  
Xianyong Lan ◽  
...  
Keyword(s):  
Copy Number ◽  
Growth Traits ◽  
Gene Copy Number ◽  
Copy Number Variations ◽  
Gene Copy ◽  
Transcriptional Expression ◽  
Chinese Cattle ◽  
Myh3 Gene

scholarly journals Genome instability drives epistatic adaptation in the human pathogen Leishmania

2021 ◽  
Vol 118 (51) ◽  
pp. e2113744118
Author(s):  
Giovanni Bussotti ◽  
Laura Piel ◽  
Pascale Pescher ◽  
Malgorzata A. Domagalska ◽  
K. Shanmugha Rajan ◽  
...  
Keyword(s):  
Translational Control ◽  
Copy Number ◽  
Biomarker Discovery ◽  
Genome Instability ◽  
Gene Dosage ◽  
Gene Copy Number ◽  
Copy Number Variations ◽  
Gene Copy ◽  
Snorna Gene ◽  
Ideal System

How genome instability is harnessed for fitness gain despite its potential deleterious effects is largely elusive. An ideal system to address this important open question is provided by the protozoan pathogen Leishmania, which exploits frequent variations in chromosome and gene copy number to regulate expression levels. Using ecological genomics and experimental evolution approaches, we provide evidence that Leishmania adaptation relies on epistatic interactions between functionally associated gene copy number variations in pathways driving fitness gain in a given environment. We further uncover posttranscriptional regulation as a key mechanism that compensates for deleterious gene dosage effects and provides phenotypic robustness to genetically heterogenous parasite populations. Finally, we correlate dynamic variations in small nucleolar RNA (snoRNA) gene dosage with changes in ribosomal RNA 2′-O-methylation and pseudouridylation, suggesting translational control as an additional layer of parasite adaptation. Leishmania genome instability is thus harnessed for fitness gain by genome-dependent variations in gene expression and genome-independent compensatory mechanisms. This allows for polyclonal adaptation and maintenance of genetic heterogeneity despite strong selective pressure. The epistatic adaptation described here needs to be considered in Leishmania epidemiology and biomarker discovery and may be relevant to other fast-evolving eukaryotic cells that exploit genome instability for adaptation, such as fungal pathogens or cancer.

Associations of GBP2 gene copy number variations with growth traits and transcriptional expression in Chinese cattle

Gene ◽  
2018 ◽  
Vol 647 ◽  
pp. 101-106 ◽  
Author(s):  
Gui-Min Zhang ◽  
Li Zheng ◽  
Hua He ◽  
Cheng-Chuang Song ◽  
Zi-Jing Zhang ◽  
...  
Keyword(s):  
Copy Number ◽  
Growth Traits ◽  
Gene Copy Number ◽  
Copy Number Variations ◽  
Gene Copy ◽  
Transcriptional Expression ◽  
Chinese Cattle
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