Development of a precipitation-resistant solution formulation to increase in vivo exposure of a poorly water-soluble compound

2012 ◽  
Vol 433 (1-2) ◽  
pp. 94-101 ◽  
Author(s):  
Lori Burton ◽  
William Ying ◽  
Rajesh Gandhi ◽  
Ronald West ◽  
Christine Huang ◽  
...  
Keyword(s):  
Water Soluble ◽  
Water Soluble Compound ◽  
Soluble Compound ◽  
Poorly Water Soluble ◽  
Solution Formulation

Impact of FaSSIF on the solubility and dissolution-/permeation rate of a poorly water-soluble compound

2012 ◽  
Vol 47 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Kerstin J. Frank ◽  
Ulrich Westedt ◽  
Karin M. Rosenblatt ◽  
Peter Hölig ◽  
Jörg Rosenberg ◽  
...  
Keyword(s):  
Permeation Rate ◽  
Water Soluble ◽  
Water Soluble Compound ◽  
Soluble Compound ◽  
Poorly Water Soluble

scholarly journals Dry amorphisation of mangiferin, a poorly water-soluble compound, using mesoporous silica

2019 ◽  
Vol 141 ◽  
pp. 172-179 ◽  
Author(s):  
Adrienn Baán ◽  
Peter Adriaensens ◽  
Joris Lammens ◽  
René Delgado Hernandez ◽  
Wim Vanden Berghe ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Water Soluble ◽  
Water Soluble Compound ◽  
Soluble Compound ◽  
Poorly Water Soluble

scholarly journals In vivo evaluation of modified gum karaya as a carrier for improving the oral bioavailability of a poorly water-soluble drug, nimodipine

2002 ◽  
Vol 3 (2) ◽  
pp. 55-63 ◽  
Author(s):  
Gedela V. Murali Mohan Babu ◽  
Namballa R. Kumar ◽  
Kasina H. Sankar ◽  
Battu J. Ram ◽  
Namburu K. Kumar ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Water Soluble ◽  
In Vivo Evaluation ◽  
Gum Karaya ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

Synthesis of propylene glycol phospholipids: analogues of α-lecithins and α-cephalins

1968 ◽  
Vol 46 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Erich Baer ◽  
Angus J. Duke ◽  
Dmytro Buchnea
Keyword(s):  
Propylene Glycol ◽  
Hemolytic Activity ◽  
Polyhydric Alcohol ◽  
Water Soluble ◽  
Asymmetric Center ◽  
Water Soluble Compound ◽  
Soluble Compound ◽  
Dipalmitoyl Lecithin

The synthesis of phospholipids derived from propylene glycol, structurally the least complex polyhydric alcohol to possess an asymmetric center, is described. Representatives of two types of propylene glycol phospholipids were prepared. They are analogues of α-(dipalmitoyl)lecithin and α-(dipalmitoyl)cephalin, and were obtained from D-propylene glycol via the following two series of intermediates: (A) α-trityl D-propylene glycol (I) → α-trityl, β-palmitoyl D-propylene glycol (II) → β-palmitoyl D-propylene glycol (III) → β-palmitoyl D-propylene glycol-α-(phenyl)phosphorylcholine chloride (IV) → β-palmitoyl D-propylene glycol-α-phosphorylcholine (V); and (B) I → II → III → β-palmitoyl D-propylene glycol-α-(phenyl)phosphoryl-N-carbobenzoxyethanolamine (VI) → β-palmitoyl D-propylene glycol-α-phosphorylethanolamine (VII). The palmitoyl D-propylene glycol-α-phosphorylcholine, a highly water-soluble compound, possesses strong hemolytic activity, whereas the palmitoyl D-propylene glycol-α-phosphorylethanolamine has no hemolytic properties whatsoever.

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