Mesoporous Silica
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2022 ◽  
Vol 15 (1) ◽  
pp. 93
Arif Budiman ◽  
Diah Lia Aulifa

The incorporation of a drug into mesoporous silica (MPS) is a promising strategy to stabilize its amorphous form. However, the drug within MPS has shown incomplete release, despite a supersaturated solution being generated. This indicates the determination of maximum drug loading in MPS below what is experimentally necessary to maximize the drug doses in the system. Therefore, this study aimed to characterize the drugs with good glass former loaded-mesoporous silica, determine the maximum drug loading, and compare its theoretical value relevance to monolayer covering the mesoporous (MCM) surface, as well as pore-filling capacity (PFC). Solvent evaporation and melt methods were used to load each drug into MPS. In addition, the glass transition of ritonavir (RTV) and cyclosporine A (CYP), as well as the melting peak of indomethacin (IDM) and saccharin (SAC) in mesoporous silica, were not discovered in the modulated differential scanning calorimetry (MDSC) curve, demonstrating that each drug was successfully incorporated into the mesopores. The amorphization of RTV-loaded MPS (RTV/MPS), CYP-loaded MPS (CYP/MPS), and IDM-loaded MPS (IDM/MPS) were confirmed as a halo pattern in powder X-ray diffraction measurements and a single glass transition event in the MDSC curve. Additionally, the good glass formers, nanoconfinement effect of MPS and silica surface interaction contributed to the amorphization of RTV, CYP and IDM within MPS. Meanwhile, the crystallization of SAC was observed in SAC-loaded MPS (SAC/MPS) due to its weak silica surface interaction and high recrystallization tendency. The maximum loading amount of RTV/MPS was experimentally close to the theoretical amount of MCM, showing monomolecular adsorption of RTV on the silica surface. On the other hand, the maximum loading amount of CYP/MPS and IDM/MPS was experimentally lower than the theoretical amount of MCM due to the lack of surface interaction. However, neither CYP or IDM occupied the entire silica surface, even though some drugs were adsorbed on the MPS surface. Moreover, the maximum loading amount of SAC/MPS was experimentally close to the theoretical amount of PFC, suggesting the multilayers of SAC within the MPS. Therefore, this study demonstrates that the characterization of drugs within MPS, such as molecular size and interaction of drug-silica surface, affects the loading efficiency of drugs within MPS that influence its relevance with the theoretical value of drugs.

2022 ◽  
Vol 12 (1) ◽  
pp. 61
Saif-ur-Rehman ◽  
Muhammad Khaliq U Zaman ◽  
Muhammad Ahsan Waseem ◽  
Shafiq Uz Zaman ◽  
Muhammad Shozab Mehdi

In this research, a novel DES (choline chloride + decanoic acid) was synthesized, and SBA-15 was functionalized by the DES to form a DES-SBA filler to fabricate MMMs. DES-SBA-based MMMs at 5%, 10%, 15%, and 20% were synthesized and evaluated. The DES-SBA-based MMMs were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Gas permeation tests were applied to the pure and mixed gas samples, and the results of the permeability and selectivity (CO2/CH4, and CO2/N2) of the membranes are reported. DES modification of SBA-15 increased the efficiency of the synthesized MMMs in comparison with the pristine polysulfone membrane.

Nathália Saraiva Rios ◽  
Talita Lopes Honorato ◽  
Juan Antonio Cecilia ◽  
Enrique Rodríguez-Castellón ◽  
Maria Alice Zarur Coelho ◽  

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 163
Elena Álvarez ◽  
Manuel Estévez ◽  
Alvaro Gallo-Cordova ◽  
Blanca González ◽  
Rafael R. Castillo ◽  

A crucial challenge to face in the treatment of biofilm-associated infection is the ability of bacteria to develop resistance to traditional antimicrobial therapies based on the administration of antibiotics alone. This study aims to apply magnetic hyperthermia together with controlled antibiotic delivery from a unique magnetic-responsive nanocarrier for a combination therapy against biofilm. The design of the nanosystem is based on antibiotic-loaded mesoporous silica nanoparticles (MSNs) externally functionalized with a thermo-responsive polymer capping layer, and decorated in the outermost surface with superparamagnetic iron oxide nanoparticles (SPIONs). The SPIONs are able to generate heat upon application of an alternating magnetic field (AMF), reaching the temperature needed to induce a change in the polymer conformation from linear to globular, therefore triggering pore uncapping and the antibiotic cargo release. The microbiological assays indicated that exposure of E. coli biofilms to 200 µg/mL of the nanosystem and the application of an AMF (202 kHz, 30 mT) decreased the number of viable bacteria by 4 log10 units compared with the control. The results of the present study show that combined hyperthermia and antibiotic treatment is a promising approach for the effective management of biofilm-associated infections.

Griselda Castruita‐de León ◽  
Ángel de Jesús Montes‐Luna ◽  
Claudia Y. Yeverino‐Miranda ◽  
Germán Alvarado‐Tenorio ◽  
Héctor Iván Meléndez‐Ortiz ◽  

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