Impact of FaSSIF on the solubility and dissolution-/permeation rate of a poorly water-soluble compound

2012 ◽  
Vol 47 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Kerstin J. Frank ◽  
Ulrich Westedt ◽  
Karin M. Rosenblatt ◽  
Peter Hölig ◽  
Jörg Rosenberg ◽  
...  
Keyword(s):  
Permeation Rate ◽  
Water Soluble ◽  
Water Soluble Compound ◽  
Soluble Compound ◽  
Poorly Water Soluble

Development of a precipitation-resistant solution formulation to increase in vivo exposure of a poorly water-soluble compound

2012 ◽  
Vol 433 (1-2) ◽  
pp. 94-101 ◽  
Author(s):  
Lori Burton ◽  
William Ying ◽  
Rajesh Gandhi ◽  
Ronald West ◽  
Christine Huang ◽  
...  
Keyword(s):  
Water Soluble ◽  
Water Soluble Compound ◽  
Soluble Compound ◽  
Poorly Water Soluble ◽  
Solution Formulation

scholarly journals Dry amorphisation of mangiferin, a poorly water-soluble compound, using mesoporous silica

2019 ◽  
Vol 141 ◽  
pp. 172-179 ◽  
Author(s):  
Adrienn Baán ◽  
Peter Adriaensens ◽  
Joris Lammens ◽  
René Delgado Hernandez ◽  
Wim Vanden Berghe ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Water Soluble ◽  
Water Soluble Compound ◽  
Soluble Compound ◽  
Poorly Water Soluble

Synthesis of propylene glycol phospholipids: analogues of α-lecithins and α-cephalins

1968 ◽  
Vol 46 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Erich Baer ◽  
Angus J. Duke ◽  
Dmytro Buchnea
Keyword(s):  
Propylene Glycol ◽  
Hemolytic Activity ◽  
Polyhydric Alcohol ◽  
Water Soluble ◽  
Asymmetric Center ◽  
Water Soluble Compound ◽  
Soluble Compound ◽  
Dipalmitoyl Lecithin

The synthesis of phospholipids derived from propylene glycol, structurally the least complex polyhydric alcohol to possess an asymmetric center, is described. Representatives of two types of propylene glycol phospholipids were prepared. They are analogues of α-(dipalmitoyl)lecithin and α-(dipalmitoyl)cephalin, and were obtained from D-propylene glycol via the following two series of intermediates: (A) α-trityl D-propylene glycol (I) → α-trityl, β-palmitoyl D-propylene glycol (II) → β-palmitoyl D-propylene glycol (III) → β-palmitoyl D-propylene glycol-α-(phenyl)phosphorylcholine chloride (IV) → β-palmitoyl D-propylene glycol-α-phosphorylcholine (V); and (B) I → II → III → β-palmitoyl D-propylene glycol-α-(phenyl)phosphoryl-N-carbobenzoxyethanolamine (VI) → β-palmitoyl D-propylene glycol-α-phosphorylethanolamine (VII). The palmitoyl D-propylene glycol-α-phosphorylcholine, a highly water-soluble compound, possesses strong hemolytic activity, whereas the palmitoyl D-propylene glycol-α-phosphorylethanolamine has no hemolytic properties whatsoever.

Darstellung von Peroxotantalaten durch Perhydrolyse von Tantal(V)-äthanolat / Preparation of Peroxotantalates by Perhydrolysis of Tantalum(V)ethoxide

1973 ◽  
Vol 28 (9-10) ◽  
pp. 590-594 ◽  
Author(s):  
J. Fuchs ◽  
D. Lubkoll
Keyword(s):  
Petroleum Ether ◽  
Molecular Mass ◽  
Water Soluble ◽  
Organic Cations ◽  
Water Soluble Compound ◽  
Soluble Compound ◽  
First Time

Tetraperoxotantalates with organic cations as well as an oligomeric peroxopolytantalate were prepared for the first time by perhydrolysis of tantalum(V)ethoxide, Ta(OC2H5)5, in the presence of bases. Guanidinium, tert-butylammonium and cyclohexylammonium salts of tetraperoxotantalic acid crystallize from ethanol as relatively stable compounds. The cell constants of these compounds are determined. By perhydrolysis of the ester in petroleum ether the tert-butylammonium salt of a peroxododecantalic acid was obtained. The molecular mass of this water soluble compound was determined with the ultracentrifuge.

Sustained release of a model water-soluble compound via dry powder aerosolizable acetalated dextran microparticles

2019 ◽  
Vol 24 (9) ◽  
pp. 1133-1143 ◽  
Author(s):  
Nishan K. Shah ◽  
Zimeng Wang ◽  
Sweta K. Gupta ◽  
Andrew Le Campion ◽  
Samantha A. Meenach
Keyword(s):  
Sustained Release ◽  
Water Soluble ◽  
Dry Powder ◽  
Water Soluble Compound ◽  
Soluble Compound ◽  
Model Water
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