The effect of poly(ethylene glycol) coating on colloidal stability of superparamagnetic iron oxide nanoparticles as potential MRI contrast agent

2012 ◽  
Vol 433 (1-2) ◽  
pp. 129-141 ◽  
Author(s):  
Afshin Masoudi ◽  
Hamid Reza Madaah Hosseini ◽  
Mohammad Ali Shokrgozar ◽  
Reza Ahmadi ◽  
Mohammad Ali Oghabian
Keyword(s):  
Iron Oxide ◽  
Ethylene Glycol ◽  
Contrast Agent ◽  
Colloidal Stability ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Mri Contrast ◽  
Poly Ethylene

scholarly journals Iron oxide nanoparticles stabilized with dendritic polyglycerols as selective MRI contrast agents

Nanoscale ◽  
2014 ◽  
Vol 6 (16) ◽  
pp. 9646-9654 ◽  
Author(s):  
Daniel Nordmeyer ◽  
Patrick Stumpf ◽  
Dominic Gröger ◽  
Andreas Hofmann ◽  
Sven Enders ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Iron Oxide ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Mri Contrast

Superparamagnetic iron oxide nanoparticles with a dendritic polyglycerol (dPG) sulfate strongly bind to L- and P-selectin. Shielding of leukocytes reduces cell extravasation and binding to endothelial cells indicate inflammation specificity and thus, applicability as selective MRI contrast agent.

scholarly journals Synthesis of Superparamagnetic Iron Oxide Nanoparticles Modified with MPEG-PEI via Photochemistry as New MRI Contrast Agent

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Yancong Zhang ◽  
Lianying Zhang ◽  
Xinfeng Song ◽  
Xiangling Gu ◽  
Hanwen Sun ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Resonance ◽  
Ethylene Glycol ◽  
Iron Oxide Nanoparticles ◽  
Methyl Ether ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Novel method for synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) coated with polyethylenimine (PEI) and modified with poly(ethylene glycol) methyl ether (MPEG), MPEG-PEI-SPIONs, was developed. PEI-SPIONs were successfully prepared in aqueous system via photochemistry, and their surface was modified with poly(ethylene glycol) methyl ether (MPEG). The so-obtained MPEG-PEI-SPIONs had a uniform hydrodynamic particle size of 34 nm. The successful coating of MPEG-PEI on the SPIONs was ascertained from FT-IR analysis, and the PEI and MPEG fractions in MPEG-PEI-SPIONs were calculated to account for 31% and 12%, respectively. Magnetic measurement revealed that the saturated magnetization of MPEG-PEI-SPIONs reached 46 emu/g and the nanoparticles showed the characteristic of being superparamagnetic. The stability experiment revealed that the MPEG-PEI modification improved the nanoparticles stability greatly.T2 relaxation measurements showed that MPEG-PEI-SPIONs show similarR2 value to the PEI-SPIONs. TheT2-weighted magnetic resonance imaging (MRI) of MPEG-PEI-SPIONs showed that the magnetic resonance signal was enhanced significantly with increasing nanoparticle concentration in water. These results indicated that the MPEG-PEI-SPIONs had great potential for application in MRI.

Cubic mesophase nanoparticles doped with superparamagnetic iron oxide nanoparticles: a new class of MRI contrast agent

RSC Advances ◽  
2012 ◽  
Vol 2 (16) ◽  
pp. 6655 ◽  
Author(s):  
Durga P. Acharya ◽  
Bradford A. Moffat ◽  
Anastasios Polyzos ◽  
Lynne Waddington ◽  
Greg Coia ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Mri Contrast ◽  
New Class
Sign in / Sign up

Export Citation Format

Share Document